Skip to main content
SpringerLink
Log in

Therapeutic Apheresis

  • Chapter
  • First Online:
Pediatric Dialysis Case Studies

  • 799 Accesses

Abstract

Therapeutic apheresis procedures aim to remove a pathologic substance from a patient’s blood via mechanical means through a centrifuge or filtration mechanism. In pediatric nephrology, therapeutic plasma exchange targets removal of antibodies or other pathologic proteins and replaces the plasma with either albumin or plasma. Plasma exchange is usually combined with immunosuppressive medication regimens to prevent/reduce antibody production. The cases presented in this chapter highlight treatment considerations for an aggressive acute glomerulonephritis and for one of the more common disease indications for therapeutic plasma exchange in pediatric nephrology: focal segmental glomerulosclerosis (FSGS).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51(2):224–32.

    PubMed  Google Scholar 

  2. Szczepiorkowski ZM, Winters JL, Bandarenko N, Kim HC, Linenberger ML, Marques MB, et al. Guidelines on the use of therapeutic apheresis in clinical practice – evidence-based approach from the apheresis applications Committee of the American Society for apheresis. J Clin Apher. 2010;25(3):83–177.

    Article  PubMed  Google Scholar 

  3. Savin VJ, Sharma R, Sharma M, McCarthy ET, Swan SK, Ellis E, et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med. 1996;334(14):878–83.

    Article  CAS  PubMed  Google Scholar 

  4. Keith DS. Therapeutic apheresis rescue mission: recurrent focal segmental glomerulosclerosis in renal allografts. Semin Dial. 2012;25(2):190–2.

    Article  PubMed  Google Scholar 

  5. Davenport RD. Apheresis treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation: re-analysis of published case-reports and case-series. J Clin Apher. 2001;16(4):175–8.

    Article  CAS  PubMed  Google Scholar 

  6. Baum MA, Stablein DM, Panzarino VM, Tejani A, Harmon WE, Alexander SR. Loss of living donor renal allograft survival advantage in children with focal segmental glomerulosclerosis. Kidney Int. 2001;59(1):328–33.

    Article  CAS  PubMed  Google Scholar 

  7. Ohta T, Kawaguchi H, Hattori M, Komatsu Y, Akioka Y, Nagata M, et al. Effect of pre-and postoperative plasmapheresis on posttransplant recurrence of focal segmental glomerulosclerosis in children. Transplantation. 2001;71(5):628–33.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Acute Care Nephrology, Pheresis Service, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Stuart L. Goldstein MD

  2. University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Stuart L. Goldstein MD

Authors
  1. Stuart L. Goldstein MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stuart L. Goldstein MD .

Editor information

Editors and Affiliations

  1. Division of Pediatric Nephrology, University of Missouri, Kansas City School of Medicine, Children’s Mercy Hospital, Kansas City, Missouri, USA

    Bradley A Warady

  2. Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany

    Franz Schaefer

  3. Division of Pediatric Nephrology, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children’s Hospital Stanford, Stanford, California, USA

    Steven R. Alexander

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Goldstein, S.L. (2017). Therapeutic Apheresis. In: Warady, B., Schaefer, F., Alexander, S. (eds) Pediatric Dialysis Case Studies. Springer, Cham. https://doi.org/10.1007/978-3-319-55147-0_40

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55147-0_40

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55145-6

  • Online ISBN: 978-3-319-55147-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation