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Diagnostic Evaluation of Huntington’s Disease Within the Frame of Bioinformatics

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GeNeDis 2016

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 987))

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Abstract

Huntington’s disease is an autosomal dominant neurodegenerative disorder characterized by motor and cognitive impairment. At the early stages of the disease scientists have observed psychological changes and differences in patients’ alpha, beta and theta powers. The early diagnosis of Huntington’s disease is very important in order to administrate the correct medication to the patients and slow down the progress of the disease. This paper aims to suggest a protocol in which experiments could be based on, in an attempt to make an early diagnosis of the disease by taking into consideration the patients’ electroencephalographic recordings during the early stages of the disease, as well as the methods of processing and classifying those EEG signals.

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References

  1. Ross, Ch.A., and S.J. Tabrizi. “Huntington’s Disease: from Molecular Pathogenesis to Clinical Treatment”. Departments of Psychiatry, Neurology, Pharmacology, and Neuroscience, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA (C A Ross MD); and Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK (S J Tabrizi FRCP).

    Google Scholar 

  2. Bobori, C. “Molecular Genetics of Huntington’s Disease”. 7 Tsirigoti Square, Corfu, Greece: Department of Informatics, Ionian University.

    Google Scholar 

  3. Walker, F.O. “Huntington’s Disease”. Medical Center Blvd, Winston Salem, NC 27157, USA: Department of Neurology, Wake Forest University.

    Google Scholar 

  4. Rubinsztein, D.C. “The Molecular Pathology of Huntington’s Disease(HD)”. Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 2XY, UK: Department of Medical Genetics, Cambridge Institute for Medical Research.

    Google Scholar 

  5. Bay, J., A. Graves, H. Mora, M. Dragunow, P. Narayan, and R. Faull. “Huntington’s Disease: Understanding a mutation”, LENScience Connect Senior Biology Seminar Series. The University of Auckland.

    Google Scholar 

  6. Foroud, T., J. Gray, J. Ivashina, and P.M. Conneally. “Differences in Duration of Huntington’s Disease Based on Age at Onset”. Indianapolis, In, USA: Department of Medical and Molecular Genetics, Indiana University School of Medicine.

    Google Scholar 

  7. Fox, L. “Mapping the Anatomy of HD: A whole – Brain History”. http://en.hdbuzz.net/205.

  8. Plerou, A., C. Bobori, and P. Vlamos. 2015. Molecular Basis of Huntington’s Disease and Brain Imaging Evidence. In 15th IEEE International Symposium on Signal Processing and Information Technology (ISSPIT 2015).

    Google Scholar 

  9. Κόλλιας, Χ. “Καταγραφή και Ανάλυση Βιοδυναμικών Εγκεφάλου με χρήση του Συστήματος BIOPAC”, Πανεπιστήμιο Πατρών, Διατμηματικό Πρόγραμeμα μεταπτυχιακών Σπουδών στην Ιατρική Φυσική, Πάτρα 2012.

    Google Scholar 

  10. Dr. Chow, F.L. “The 10 – 20 International System of Electrode Placement Basic EEG”, http://www.hksccm.org/files/Presentations/CCM_-_Basic_EEG.pdf.

  11. Picton, T.W., S. Bentin, P. Berg, E. Donchin, S.A. Hillyard, R. Johnson Jr., G.A. Miller, W. Ritter, D.S. Ruchkin, M.D. Rugg, and M.J. Taylor. 2000. Guidelines for Using Human Event-Related Potentials to Study Cognition: Recording Standards and Publication Criteria. Psychophysiology 37: 127–152. Printed in the USA.Copyright © 2000 Society for Psychophysiological Research.

    Article  CAS  PubMed  Google Scholar 

  12. Bishop, Ch.M. 2006. Pattern Recognition and Machine Learning (Information Science and Statistics). New York: Springer.

    Google Scholar 

  13. Lotte, F. 2014. A Tutorial on EEG Signal Processing Techniques for Mental State Recognition Inn Brain – Computer Interfaces. In Guide to Brain – Computer Music Interfaces, eds. Eduardo Reck Miranda, Castet, Springer. HAL Id: hal-01055103, https://hal.inria.fr/hal-01055103.

    Google Scholar 

  14. Hruby, T., P. Marsalek. “Event-Related Potentials - The P3 Wave”, Charles University Prague, Department of Psychiatry, First Medical Faculty, Ke Karlovu 11, Praha 2, CZ-128 08, Department of Pathological Physiology, First Medical Faculty, U nemocnice 5, Praha 2, CZ-128 53, Czech Republic.

    Google Scholar 

  15. Welling, Max. “Fisher Linear Discriminant Analysis”. 10 King’s College Road, Toronto, M5S 3G5, Canada: Department of Computer Science, University of Toronto.

    Google Scholar 

  16. Γ.Ε. Κοκολάκης, “Σημειώσεις Ανάλυσης Χρονοσειρών”.

    Google Scholar 

  17. Raven, J.C., et al. 1998. Raven’s Progressive Matrices and Vocabulary Scales. Oxford: Oxford Psychologists Press.

    Google Scholar 

  18. Butcher, James Neal. 1990 Butcher James Neal, “The MMPI-2 in Psychological Treatment”. New York, NY: Oxford University Press. The MMPI-2 in psychological treatment. ix 195 pp.

    Google Scholar 

  19. Delis, D.C., J.H. Kramer, E. Kaplan, and B.A. Ober. 1987. Verbal Learning Test: Adult Version: Manual. CVLT, California: Psychological Corporation.

    Google Scholar 

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Correspondence to Catherine Bobori .

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Bobori, C. (2017). Diagnostic Evaluation of Huntington’s Disease Within the Frame of Bioinformatics. In: Vlamos, P. (eds) GeNeDis 2016. Advances in Experimental Medicine and Biology, vol 987. Springer, Cham. https://doi.org/10.1007/978-3-319-57379-3_11

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