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Nuclear DAMPs in Hepatic Injury and Inflammation

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Molecules, Systems and Signaling in Liver Injury

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Inflammation during tissue injury normally serves as a natural restorative response to wound healing and tissue regeneration. However, an excessive or uncontrolled inflammatory response can lead to further tissue injury through the release of damage-associated molecular pattern molecules (DAMPs). Different from pathogen-associated molecular pattern molecules (PAMPs) generated from foreign pathogens, DAMPs are endogenous molecules released by dead or dying cells. Both DAMPs and PAMPs can trigger inflammatory and immune responses through pattern recognition receptors such as toll-like receptors and the receptor for advanced glycation end products. Blocking the interplay between DAMPs and their receptors protects against inflammatory-associated diseases. This chapter will focus on the role of nuclear DAMPs, such as high-mobility group box 1 and histone, in linking regulated cell death and sterile inflammation during liver injury from drugs, alcohol, viruses, trauma, and cancer.

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Acknowledgments

We apologize to the researchers who were not referenced due to space limitations. We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by the National Institutes of Health of the USA (R01GM115366 and R01CA160417 to D.T.), the National Natural Science Foundation of Guangdong (2016A030308 D.T.), and a Research Scholar Grant from the American Cancer Society (RSG-16-014-01-CDD to D.T.).

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  1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Rui Kang & Daolin Tang

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  1. Rui Kang
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  2. Daolin Tang
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Correspondence to Rui Kang or Daolin Tang .

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  1. Department of Pharmacology Toxicology and Therapy, The University of Kansas Medical Center, Kansas City, Kansas, USA

    Wen-Xing Ding

  2. Health Pathology Laboratory, Indiana University, Indianapolis, Indiana, USA

    Xiao-Ming Yin

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Kang, R., Tang, D. (2017). Nuclear DAMPs in Hepatic Injury and Inflammation. In: Ding, WX., Yin, XM. (eds) Molecules, Systems and Signaling in Liver Injury. Cell Death in Biology and Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-58106-4_7

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