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The Dyspraxia Scale for Adults with Down Syndrome

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Neuropsychological Assessments of Dementia in Down Syndrome and Intellectual Disabilities

Abstract

Dyspraxia consists of a partial loss of the ability to perform purposeful or skilled motor acts in the absence of paralysis, sensory loss, abnormal posture or tone, abnormal involuntary movements, incoordination, poor comprehension, or inattention [1]. The existence of dyspraxia is usually tested by having the patient perform some motor act on command or by imitation.

†Author was deceased at the time of publication. See Obituary p303–304.

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References

  1. Lohr JB, Wisniewski AA. Movement disorders: a neuropsychiatric approach. New York: Guilford Press; 1987.

    Google Scholar 

  2. Smits LL, Flapper M, Sistermans N, Pijnenburg YA, Scheltens P, van der Flier WM. Apraxia in mild cognitive impairment and Alzheimer's disease: validity and reliability of the Van Heugten test for apraxia. Dement Geriatr Cogn Disord. 2014;38:55–64.

    Article  CAS  PubMed  Google Scholar 

  3. Zoia S, Pelamatti G, Rumiati RI. Praxic skills in down and mentally retarded adults: evidence for multiple action routes. Brain Cogn. 2014;54:7–17.

    Article  Google Scholar 

  4. Orange JB, Zanon MV. Language and communication in adults with Down syndrome and dementia of the Alzheimer type: a review. J Develop Disabil. 2005;12:53–62.

    Google Scholar 

  5. Prasher VP. Age-specific prevalence, thyroid dysfunction and depressive symptomatology in adults with Down syndrome and dementia. Int J Geriatr Psychiatry. 1995;10:25–31.

    Article  Google Scholar 

  6. Prasher VP. Differential diagnosis between Alzheimer’s disease and hypothyroidism in adults with Down syndrome. Downs Syndr Res Pract. 1995;3:15–8.

    Article  Google Scholar 

  7. Prasher VP, Filer A. Behavioural disturbance in people with Down’s syndrome and dementia. J Intellect Disabil Res. 1995;39:432–6.

    Article  PubMed  Google Scholar 

  8. Dalton AJ, Crapper-McLachlan DR. Clinical expression of Alzheimer’s disease in Down’s syndrome. Psychiatr Clin North Am. 1986;9:659–70.

    CAS  PubMed  Google Scholar 

  9. Aylward EH, Burt DB, Thorpe LU, et al. Diagnosis of dementia in individuals with intellectual disability. J Intellect Disabil Res. 1997;41:152–64.

    Article  PubMed  Google Scholar 

  10. Oliver C. Perspective on assessment and evaluation. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

  11. Burt DB, Aylward EH. Assessment methods for diagnosis of dementia. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

  12. Prasher VP. Alzheimer’s disease and dementia in Down syndrome and intellectual disabilities. Oxford: Radcliffe Publishing; 2005.

    Google Scholar 

  13. Ulrich DA, Riggen KJ, Ozmun JC, et al. Assessing movement control in children with mental retardation: a generalizability analysis of observers. Am J Ment Retard. 1989;94:161–8.

    Google Scholar 

  14. Kertesz A, Poole H. The taxonomic approach to measurement of aphasic disability. Can J Neurol Sci. 1974;16:1–7.

    Google Scholar 

  15. Kertesz A. Western aphasia battery. New York: Grune and Stratton; 1982.

    Google Scholar 

  16. Kertez A. Language deterioration in dementia. In: Emery VOB, Oxman TE, editors. Dementia presentation, differential diagnosis, and nosology. Baltimore: Johns Hopkins University Press; 1994.

    Google Scholar 

  17. Crapper-McLachlan DR, Dalton AJ, Kruck TPA, et al. Desferrioxamine in Alzheimer disease. Lancet. 1991;337:1304–8.

    Article  CAS  PubMed  Google Scholar 

  18. McLachlan DR, Smith WL, Kruck TP. Desferrioxamine and Alzheimer’s disease: video home behavior assessment of clinical course and measures of brain aluminium. Drug Monitor. 1993;15:602–7.

    Article  CAS  Google Scholar 

  19. Dalton AJ, Mehta PD, Fedor BL, et al. Cognitive changes in memory precede those in praxis in aging persons with Down syndrome. J Intellect Develop Disabil. 1999;24:169–87.

    Article  Google Scholar 

  20. Sano M, Aisen PS, Dalton AJ, et al. Assessment of aging individuals with Down syndrome in clinical trials: results of baseline measures. J Policy Pract Intellect Disabil. 2005;2:126–38.

    Article  Google Scholar 

  21. Dalton AJ, Fedor BL. Onset dyspraxia in aging persons with Down syndrome: longitudinal studies. J Intellect Develop Disabil. 1998;23:13–24.

    Article  Google Scholar 

  22. Devenny DA, Silverman WP, Hill AL, et al. Normal aging in adults with Down’s syndrome: a longitudinal study. J Intellect Disabil Res. 1996;40:208–21.

    Article  PubMed  Google Scholar 

  23. Dalton AJ. Dementia in Down syndrome: methods of evaluation. In: Nadel L, Rosenthal D, editors. Down syndrome and alzheimer disease. New York: Wiley-Liss; 1992.

    Google Scholar 

  24. Dalton AJ, Fedor BL. Dyspraxia scale for adults with Down syndrome. New York: NYS Institute for Basic. Research; 1997.

    Google Scholar 

  25. Dalton AJ, McMurray K. The Dalton/McMurray visual memory test. Waterloo: Bytecraft; 1995.

    Google Scholar 

  26. Dalton AJ, Fedor BL, Patti PJ, et al. The multidimensional observation scale for elderly subjects (MOSES): studies in adults with intellectual disability. J Intellect Develop Disabil. 2002;27:310–24.

    Article  Google Scholar 

  27. Evenhuis HM, Kengen MMF, Eurlings HAL. Dementia questionnaire for mentally retarded persons. Zwammerdam: Hooge Burch Institute for Mentally Retarded People; 1990.

    Google Scholar 

  28. Evenhuis HM. Evaluation of a screening instrument for dementia in ageing mentally retarded persons. J Intellect Disabil Res. 1992;36:337–47.

    Article  PubMed  Google Scholar 

  29. Sano M, Aisen PS, Andrews HF, Tsai WY, Lai F, Dalton AJ, International Down Syndrome and Alzheimer’s Disease Consortium. Vitamin E in aging persons with Down syndrome: a randomized, placebo-controlled clinical trial. Neurology. 2016;86:2071–76.

    Google Scholar 

  30. Lott IT, Doran E, Nguyen VQ, Tournay A, Movsesyan N, Gillen DL. Down syndrome and dementia: seizures and cognitive decline. J Alzheimers Dis. 2012;29:177–85.

    PubMed  PubMed Central  Google Scholar 

  31. Walsh DM, Doran E, Silverman W, Tournay A, Movsesyan N, Lott IT. Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status. J Intellect Disabil Res. 2015;59:1071–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiol Aging. 2014;35:1562–9.

    Google Scholar 

  33. Lin AL, Powell D, Caban-Holt A, Jicha G, Robertson W, Gold BT, Davis R, Abner E, Wilcock DM, Schmitt FA, Head E. (1)H-MRS metabolites in adults with Down syndrome: effects of dementia. Neuroimage Clin. 2016;11:728–35.

    Google Scholar 

  34. Visser FE, Aldenkamp AP, van Huffelen AC, et al. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. Am J Ment Retard. 1997;101:400–12.

    CAS  PubMed  Google Scholar 

  35. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7:263–9.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Burt DB. Dementia and depression. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

  37. Holland AJ. Down’s syndrome. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

  38. Thorpe LU. Psychiatric disorder. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

  39. Prasher VP. Adaptive behavior. In: Janicki MP, Dalton AJ, editors. Dementia, aging, and intellectual disabilities: a handbook. Philadelphia: Taylor & Francis; 1999.

    Google Scholar 

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Acknowledgments

The development work on the Dyspraxia Scale for Adults with Down Syndrome, was supported by Surrey Place Centre, Toronto, Canada, the Ontario Ministry of Community and Social Services, a Medical Research Council of Canada grant MA-5364 to Arthur J. Dalton, Ph.D., an Ontario Health Research grant PR-633 to Donald R. Crapper-McLachlan, M.D., F.R.C.P.(C), University of Toronto, a USA NICHD grant RO1-HD08993 to Arthur J. Dalton, Ph.D., an NIA grant RO1-AG08849 to Arthur J. Dalton, a grant for Subproject five of NIA Program Project PO1-AG11531 with H.M. Wisniewski as Program Director, and NIA grant RO-1 AG-16381 to Arthur J. Dalton.

The generous contributions of the following investigators who provided Dyspraxia Scale for Adults with Down Syndrome data from their own work as part of Study 2 are also gratefully acknowledged: D.B. Burt, Ph.D., F. Lai, M.D., P.J. Patti, M.A., V.P. Prasher, M.D., N. Shupf, Ph.D., and L. Thorpe, M.D., Ph.D. Y.R. Chen, Ph.D., of the University of Texas, Houston, contributed the analysis of the internal consistency of Study 1. H.F. Andrews, Ph.D., of the New York Psychiatric Research Institute in Manhattan performed the statistical analyses of the internal consistency and a factor analysis of data from Study 2 of the Dyspraxia Scale for Adults with Down Syndrome.

The work would not have been possible without the cooperation and enthusiastic support of the staff, families, and friends of the following agencies in New York State: Pathfinder Village, Inc., Independent Group Home Living, Inc., Columbia County Arc, Young Adult Institute, O.D. Heck and Brooklyn Developmental Disabilities Services Offices, New York City Chapter of the New York State Association for the Help of Retarded Citizens. The support of the New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, and the New York State Office on Mental Retardation and Developmental Disabilities are also gratefully acknowledged.

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Authors and Affiliations

  1. Department of Psychiatry, Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, USA

    Mary Sano PhD

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  1. Mary Sano PhD
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  2. Arthur J. Dalton
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Correspondence to Mary Sano PhD .

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Editors and Affiliations

  1. Visiting Professor of Neuropsychiatry, Birmingham, United Kingdom

    Vee P. Prasher

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Sano, M., Dalton, A.J. (2018). The Dyspraxia Scale for Adults with Down Syndrome. In: Prasher, V. (eds) Neuropsychological Assessments of Dementia in Down Syndrome and Intellectual Disabilities. Springer, Cham. https://doi.org/10.1007/978-3-319-61720-6_5

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  • DOI: https://doi.org/10.1007/978-3-319-61720-6_5

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