Skip to main content

Mechanical Ventilation

  • Chapter
  • First Online:
Basic Sciences in Anesthesia
  • 3608 Accesses

Abstract

Mechanical ventilation is a common occurrence in the both the operating room and intensive care units worldwide. Often the goal is only to facilitate a patient undergoing major surgery, and other times it is to prevent life-threatening deterioration. It needs to be remembered that mechanical ventilation is a supportive therapy and it almost never treats the underlying disease process. With this sentiment in mind, much of the focus of positive pressure ventilation is aimed at preventing its negative effects such as lung injury, infection, and hypotension. There are numerous ways that mechanical ventilation may damage the body. The various types of lung damage caused by ventilators are collectively known as ventilator-induced lung injury (VILI). Specific examples of VILI include causing parenchymal air leaks, also known as barotrauma, and diffuse alveolar over-distension that causes a volutrauma injury to the lung. Another mechanism of injury is due to the cyclic opening and closing of the alveoli, and this is termed atelectrauma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA. 2003;289(16):2104–12.

    Article  Google Scholar 

  2. Slutsky AS, Tremblay LN. Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med. 1998;157:1721–5.

    Article  CAS  Google Scholar 

  3. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, et al. Effect of mechanical ventilation on imflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282(1):54–61.

    Article  CAS  Google Scholar 

  4. Lachmann B. Open up the lung and keep the lung open. Intensive Care Med. 1992;18:319–21.

    Article  CAS  Google Scholar 

  5. Chatburn RL. Fundamentals of mechanical ventilation. Cleveland Heights, OH: Mandu Press Ltd.; 2003.

    Google Scholar 

  6. Chatburn RL. Classification of ventilator moeds: update and proposal for implementation. Respir Care. 2007;52(3):301–23.

    PubMed  Google Scholar 

  7. Reynolds EO. Effect of alterations in mechanical ventilator settings on pulmonary gas exchange in hyaline membrane disease. Arch Dis Child. 1971;46(246):152–9.

    Article  CAS  Google Scholar 

  8. Mercat A, Gaïni L, Teboul JL, Lenique F, Richard C. Cardiorespiratory effects of pressure-controlled ventilation with and without inverse ratio in the adult respiratory distress syndrome. Chest. 1993;104(3):871.

    Article  CAS  Google Scholar 

  9. Stawicki SP, Goyal M, Sarini B. High-frequency oscillatory ventilation (HFOV) and airway pressure release ventilation (APRV): a practical guide. J Intens Care Med. 2009;24:215–29.

    Article  CAS  Google Scholar 

  10. Borg U, Erikson I, Sjostrand U. High-frequency positive pressure ventilation (HFPPV): a review based upon its use during bronchoscopy and for laryngoscopy and microlaryngeal surgery under general anesthesia. Anesth Analg. 1980;59:594–603.

    Article  CAS  Google Scholar 

  11. Freitag L, Long WM, Kim CS, Wanner A. Removal of excessive bronchial secretions by asymmetric high-frequency oscillations. J Appl Physiol (1985). 1989;67(2):614–9.

    Article  CAS  Google Scholar 

  12. Weavind L, Wenker OC. Newer modes of ventilation: an overview. Int J Anesth. 2000;4(4). ► http://ispub.com/IJA/4/4/10738.

  13. Nicholas TE, Power JH, Barr HA. The pulmonary consequences of a deep breath. Respir Physiol. 1982;49(3):315–24.

    Article  CAS  Google Scholar 

  14. Pelosi P, Cadringer P, Bottino N, Panigada M, Carrieri F, Riva E, et al. Sigh in acute respiratory distress syndrome. Am J Respir Crit Care Med. 1999;159:872–80.

    Article  CAS  Google Scholar 

  15. Lim CM, Koh Y, Park W, Chin JY, Shim TS, Lee SD, et al. Mechanistic scheme and effect of “extended sigh” as a recruitment maneuver in patients with acute respiratory distress syndrome: a preliminary study. Crit Care Med. 2001;29:1255–60.

    Article  CAS  Google Scholar 

  16. Arnal JM, Paquet J, Wysocki M, Demory D, Donati S, Granier I, et al. Optimal duration of a sustained inflation recruitment maneuver in ARDS patients. Intensive Care Med. 2011 Oct;37(10):188–94.

    Article  Google Scholar 

  17. Rothen HU, Sporre B, Engberg G, Wegenius G, Hogman M, Hedenstiema G. Influence of gas composition on recurrence of atelectasis after a reexansion maneuver during general anesthesia. Anesthesiology. 1995;82:832–42.

    Article  CAS  Google Scholar 

  18. Brower RG, Lanken PN, MacIntyre NR, Matthay MA, Morris A, Ancukiewicz M, et al. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004; 351(4):327–336.

    Google Scholar 

  19. Celikel T, Sungur M, Ceyhan B, Karakurt S. Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure. Chest. 1998;114:1636.

    Article  CAS  Google Scholar 

  20. Lourenço RV, Cherniack NS, Malm JR, Fishman AP. Nervous output from the respiratory center during obstructed breathing. J Appl Physiol. 1966 Mar;21(2):527–33.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aaron J. Douglas .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Douglas, A.J. (2018). Mechanical Ventilation. In: Farag, E., Argalious, M., Tetzlaff, J.E., Sharma, D. (eds) Basic Sciences in Anesthesia. Springer, Cham. https://doi.org/10.1007/978-3-319-62067-1_37

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-62067-1_37

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62065-7

  • Online ISBN: 978-3-319-62067-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics