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Mixed Phenotype Acute Leukemia

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Precision Molecular Pathology of Myeloid Neoplasms

Part of the book series: Molecular Pathology Library ((MPLB,volume 12))

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Abstract

Mixed phenotype acute leukemia (MPAL) is a rare disease and accounts for 2–5% of all acute leukemias. In 2008, the World Health Organization (WHO) classification of hematopoietic and lymphoid tumors proposed a simpler diagnostic algorithm, which relies on fewer and more lineage-specific markers to define MPAL. MPAL with t(9;22) and MLL rearrangement have been separated. The 2016 revision to the WHO classification has retained the same markers. Whole-exome sequencing in MPAL patients demonstrates frequent epigenetic regulatory genes and tumor suppressor genes, specifically DNMT3A, which is found in hematologic malignancies of both lymphoid and myeloid origin, as well as in age-related clonal hematopoiesis. The prognosis of patients with MPAL is considered poor, with long-term survival of <20%, and more uniform studies are needed to achieve better outcome in this disease.

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Authors and Affiliations

  1. Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave Bader 135, Boston, MA, 02115, USA

    Olga K. Weinberg

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  1. Olga K. Weinberg
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Correspondence to Olga K. Weinberg .

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Editors and Affiliations

  1. Department of Pathology, Florida Hospital, University of Central Florida, Orlando, Florida, USA

    Chung-Che (Jeff) Chang

  2. Department of Pathology, Stanford University, Stanford, California, USA

    Robert S. Ohgami

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Weinberg, O.K. (2018). Mixed Phenotype Acute Leukemia. In: Chang, CC., Ohgami, R. (eds) Precision Molecular Pathology of Myeloid Neoplasms. Molecular Pathology Library, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-62146-3_17

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  • DOI: https://doi.org/10.1007/978-3-319-62146-3_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62144-9

  • Online ISBN: 978-3-319-62146-3

  • eBook Packages: MedicineMedicine (R0)

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