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Mutation Testing of Lung Cancer Biomarkers (Excluding IHC and NGS)

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Precision Molecular Pathology of Lung Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

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Abstract

Lung cancer represents a disease with significant morbidity and is the leading cause of cancer-related deaths worldwide. Performing molecular biomarker testing in newly diagnosed lung cancer allows improved disease prognostication and provides a mechanism for personalized therapy selection. Well-established biomarkers currently screened in non-small cell lung cancer (NSCLC) include EGFR mutations and ALK gene translocations. These two genes both represent well-characterized NSCLC biomarkers; however, new lung cancer biomarkers are emerging. In addition to new biomarkers, a wide array of molecular testing strategies are currently utilized for diagnostic lung biomarker testing. This chapter provides insight into lung cancer biomarkers though exploring the wide array of molecular testing methodologies and through examining both established and developing NSCLC (adenocarcinoma and squamous cell carcinoma) biomarkers.

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Authors and Affiliations

  1. Medical Affairs, Roche Tissue Diagnostics, Tucson, AZ, USA

    Bryce Portier MD, PhD

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  1. Bryce Portier MD, PhD
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Correspondence to Bryce Portier MD, PhD .

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Editors and Affiliations

  1. Department of Pathology & Genomic Medici, Houston Methodist Hospital, Houston, Texas, USA

    Philip T. Cagle

  2. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

    Timothy Craig Allen

  3. Department of Pathology, Mount Sinai Medical Center, New York, New York, USA

    Mary Beth Beasley

  4. Department of Pathology, Brigham & Women’s Hospital, Boston, Massachusetts, USA

    Lucian R. Chirieac

  5. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Sanja Dacic

  6. Department of Pathology, Weill Cornell Medicine, New York, New York, USA

    Alain C. Borczuk

  7. Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom

    Keith M. Kerr

  8. Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Lynette M. Sholl

  9. Medical Innovation, Roche Tissue Diagnostics, Ventana Medical Systems, Tucson, Arizona, USA

    Bryce Portier

  10. Cancer Center, Houston Methodist Hospital, Houston, Texas, USA

    Eric H. Bernicker

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Portier, B. (2018). Mutation Testing of Lung Cancer Biomarkers (Excluding IHC and NGS). In: Cagle, P., et al. Precision Molecular Pathology of Lung Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-62941-4_7

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  • DOI: https://doi.org/10.1007/978-3-319-62941-4_7

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