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The Biological Foundations of Risks from Ionizing Radiation Exposures: How an Understanding of Associated Effects Will Help Their Quantification and Mitigation

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Sustainable Risk Management

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Abstract

Ionizing radiation induces a severe form of DNA damage through clustering of ionizations: the DNA double-strand break (DSB).

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References

  • Durante, M., & Cucinotta, F. A. (2008). Heavy ion carcinogenesis and human space exploration. Nature Reviews Cancer, 8(6), 465–472.

    Article  CAS  Google Scholar 

  • Fuks, Z., & R. R. Weichselbaum (1995). Radiation therapy. In J. Mendelsohn, P. M. Howley, M. A. Israel and L. A. Liotta (Eds.), The Molecular Basis of Cancer (pp. 401–431). Philadelphia, London, Toronto, Montreal, Sydney, Tokyo: W.B. Saunders Company.

    Google Scholar 

  • Ginsburg, G. S., Angrist, M., & Cook-Deegan, R. (2006). Genomics and Medicine at a Crossroads in Chernobyl. Science, 314, 62–63.

    Article  CAS  Google Scholar 

  • Goodhead, D. T. (1989). The initial physical damage produced by ionizing radiations. International Journal of Radiation Biology, 56(5), 623–634.

    Article  CAS  Google Scholar 

  • Goodhead, D. T. (1994). Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. International Journal of Radiation Biology, 65(1), 7–17.

    Article  CAS  Google Scholar 

  • Hall, E. J., & Giaccia, A. J. (2006). Radiobiology for the Radiologist. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo: Lippincott Williams & Wilkins.

    Google Scholar 

  • Hendry, J. H. (2012). Radiation biology and radiation protection. Annals of the ICRP, 41(3–4), 64–71.

    Article  CAS  Google Scholar 

  • Iliakis, G., Murmann, T., & Soni, A. (2015). Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 793, 166–175.

    Article  CAS  Google Scholar 

  • Mladenov, E., Magin, S., Soni, A., & Iliakis, G. (2016). DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation. Seminars in Cancer Biology, 37–38, 51–64.

    Article  Google Scholar 

  • Peplow, M. (2011). Chernobyl’s legacy. Nature, 471, 562–565.

    Article  CAS  Google Scholar 

  • Schipler, A., & Iliakis, G. (2013). DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Research, 41(16), 7589–7605.

    Article  CAS  Google Scholar 

  • Ward, J. F. (1994). The Complexity of DNA damage: Relevance to biological consequences. International Journal of Radiation Biology, 66(5), 427–432.

    Article  CAS  Google Scholar 

  • Wondergem, J., Boerma, M., Kodama, K., Stewart, F., & Trott, K. (2013). Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed? Radiation and Environmental Biophysics, 52(4), 425–434.

    Article  Google Scholar 

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Acknowledgements

This work was supported in part by the DFG graduate training program (GRK1431) and grants from BMBF and BMWi.

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Correspondence to George Iliakis .

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Iliakis, G. (2018). The Biological Foundations of Risks from Ionizing Radiation Exposures: How an Understanding of Associated Effects Will Help Their Quantification and Mitigation. In: Wilderer, P., Renn, O., Grambow, M., Molls, M., Mainzer, K. (eds) Sustainable Risk Management. Strategies for Sustainability. Springer, Cham. https://doi.org/10.1007/978-3-319-66233-6_12

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