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Endophytes: Potential Source of Therapeutically Important Secondary Metabolites of Plant Origin

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Endophytes: Crop Productivity and Protection

Part of the book series: Sustainable Development and Biodiversity ((SDEB,volume 16))

Abstract

Use of plants and plant-derived metabolites for human health and well-being is as old as human civilization. The plant kingdom contains an estimated 400,000–500,000 different species and each plant produces a number of secondary metabolites which enables them to withstand various biotic and abiotic stresses. The plant secondary metabolites such as alkaloids, steroids, flavonoids , terpenoids, etc., are known to have a number of biological activities. Moreover, because of their natural origin, the plant-derived metabolites are increasingly preferred for therapeutic applications all over the world. However, the overharvesting of plants for biologically active secondary metabolites is rapidly diminishing the valuable treasure of medicinal plants. Endophytes are the microbial symbionts which live in the internal tissues of plants and mimic the chemistry of the host plant. Because of their huge diversity and ability to produce a range of metabolites similar to host plant, they have attracted significant attention of scientific community all over the world. The plant- and endophyte-derived metabolites which have attracted sufficient research in last decade include compounds with antioxidant, antihypercholesterolemic, antidiabetic, and anticancer activities. The present article reviews the current state of research on biologically active metabolites from plant and endophytic fungi. The work carried out in our lab on bioprospecting of endophytic fungi for molecules with antihypercholesterolemic potential is also included.

S. I. Mohammed and M. P. Patil have contributed equally in this work

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References

  • Abdul MI, Ramadhan MG, Soemiati A (2013) Screening of endophytic fungi from Cassia siamea lamk leaves as α-glucosidase inhibitor. Int Res J Pharm 4:128–131

    Article  Google Scholar 

  • Adediwura FJ, Bernard N, Omotola A (2011) Biochemical effects of chronic administration of Cola acuminata (P. Beauv.) Schott & Endl extracts in alloxan induced diabetic rats. Asian J Phar. Biol Res 1(3):355–359

    Google Scholar 

  • Adewale AA, Anthony CP, Zaineb FA, Miller AF, Zito SW, Adeyemi OO, Agbaje EO (2013) Antihyperglycemic profile of erinidine isolated from Hunteria umbellate seed. Afr J Tradit Complement Altern Med 10(2):189–202

    CAS  Google Scholar 

  • Agarwal R, Agarwal C, Ichikawa H, Singh RP, Agarwal BB (2006) Anticancer potential of silymarin: from bench to bed side. Anticancer Res 26(6B):4457–4498

    CAS  PubMed  Google Scholar 

  • Ahmed S, Stepp JR, Toleno RA, Peters CM (2010) Increased market integration, value, and ecological knowledge of tea agro forests in the Akha highlands of southwest China. Ecol Soc 15(4):27–44

    Article  Google Scholar 

  • Aied AM, Ali R, Ali AM, Harun H, Al-Dubai SA, Ganasegeran K, Alshagga MA, Salem SD, Abu Kasim NH (2013) Induction of caspase-9, biochemical assessment and morphological changes caused by apoptosis in cancer cells treated with goniothalamin extracted from Goniothalamus macrophyllus. Asian Pac J Cancer Prev 14(11):6273–6280

    Article  Google Scholar 

  • Akinloye OA, Solanke OO (2011) Evaluation of hypolipidemic and potential antioxidant effects of Pigeon pea (Cajanus cajan (l) mill sp.) leaves in alloxan-induced hyperglycemic rats. J Med Plants Res 5:2521–2524

    Google Scholar 

  • Akinola OB, Caxton-Martins EA, Dini L (2010) Chronic treatment with ethanolic extract of the leaves of Azadirachta indica ameliorates lesions of pancreatic islets in streptozotocin diabetes. Int J Morphol 28(1):291–302

    Article  Google Scholar 

  • Arunee H, Kornkanok I, Nanteetip L, Daniel S (2014) Ethanolic extract from derris Scandens benth mediates radiosensitzation via two distinct modes of cell death in human colon cancer HT-29 Cells. Asian Pac J Cancer Prev 15:1871–1877

    Article  Google Scholar 

  • Atmani D, Chaher N, Berboucha M, Ayouni K, Lounis H, Boudaoud H, Atmani D (2009) Antioxidant capacity and phenol content of selected Algerian medicinal plants. Food Chem 112(2):303–309

    Article  CAS  Google Scholar 

  • Baardseth P (1989) Effect of selected antioxidants on the stability of dehydrated mashed potatoes. Food Addit Contam 6:201–207

    Article  CAS  PubMed  Google Scholar 

  • Bacon CW, White JFJ (2000) Physiological adaptations in the evolution of endophytism in the Clavicipitaceae. In: Bacon CW, White JFJ (eds) Microbial endophytes. Marcel Dekker Inc., New York, NY, USA, pp 237–263

    Google Scholar 

  • Bais S, Singh GS, Sharma R (2014) Antiobesity and hypolipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Adv in Biol 2014:1–9

    Article  Google Scholar 

  • Baker D, Mocek U, Garr C (2000) Natural products vs. combinatorials: a case study. In: Wrigley SK, Hayes MA, Thomas R, Chrystal EJT, Nicholson N (eds) Biodiversity: new leads for pharmaceutical and agrochemical industries. The Royal Society of Chemistry, Cambridge, UK, pp 66–72

    Chapter  Google Scholar 

  • Baldea LAN, Martineau LC, Benhaddou-Andaloussi A, Arnason JT, Lévy É, Haddad PS (2010) Inhibition of intestinal glucose absorption by anti-diabetic medicinal plants derived from the James Bay Cree traditional pharmacopeia. J Ethnopharmacol 132(2):473–482

    Article  Google Scholar 

  • Bhargavi SD, Praveen VK, Savitha J (2014) Bioinformatic comparative analysis of lovastatin gene cluster in endophytic fungi and a soil fungus, Aspergillus terreus MOJ. Proteom Bioinform 1:26–29

    Google Scholar 

  • Birari R, Bhutani K (2007) Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today Ther 12:19–20

    Google Scholar 

  • Castaneda MP, Swiatecka-Urban A, Mitsnefes MM, Feuerstein D (2003) Activation of mitochondrial apoptotic pathways in human renal allografts after ischemia reperfusion injury. Transplantation 76:50–54

    Article  CAS  PubMed  Google Scholar 

  • Chakrabarti R, Bhavtaran S, Narendra P, Varghese N, Vanchhawng L, Mohamed Sham Shihabudeen H, Thirumurgan IVK (2011) Dipeptidyl peptidase-IV inhibitory activity of Berberis aristata. J Nat Prod 4:158–163

    CAS  Google Scholar 

  • Chatterjee M, Sarkar K, Sil PC (2006) Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiol 13(2):95–102

    Article  Google Scholar 

  • Chen Y, Guo H, Du Z, Liu XZ, Che Y, Ye X (2009) Ecology based screen identifies new metabolites from a Cordyceps colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif 42(6):838–847

    Article  CAS  PubMed  Google Scholar 

  • Cheng MJ, Wu MD, Chen JJ, Cheng YC, Hsieh MT, Hsieh SY, Yuan GF, Su YS (2014) Secondary metabolites from the endophytic fungus Annulohypoxylon stygium BCRC 34024. Chem Nat Comp 50:237–241

    Article  CAS  Google Scholar 

  • Chithra S, Jasim B, Anisha C, Jyothis M, Radhakrishnan EK (2014a) LC-MS/MS Based Identification of piperine production by endophytic Mycosphaerella sp. PF13 from Piper nigrum. Appl Biochem Biotechnol 173:30–35

    Article  CAS  PubMed  Google Scholar 

  • Chithra S, Jasim B, Sachidanandan P, Jyothis M, Radhakrishnan EK (2014b) Piperine production by endophytic fungus Colletotrichum gloeosporioides isolated from Piper nigrum. Phytomedicine 21:534–540

    Article  CAS  PubMed  Google Scholar 

  • De Bary A (1866) Morphologie und Physiologie der Pilze, Flechten, and Myxomyceten

    Google Scholar 

  • Deba F, Xuan TD, Yasuda M, Tawata S (2008) Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata. Food Control 19(4):346–352

    Article  CAS  Google Scholar 

  • Deshmukh SK, Mishra PD, Kulkarni-Almeida A, Verekar S, Sahoo MR, Periyasamy G, Goswami H, Khanna A, Balakrishnan A, Vishwakarma R (2009) Antiinflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus. Chem Biodivers 6(5):784–789

    Article  CAS  PubMed  Google Scholar 

  • Dhandapani R (2007) Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats. Indian J Exp Biol 45(7):617

    CAS  PubMed  Google Scholar 

  • Dhankhar S, Dhankhar S, Yadav JP (2013) Investigations towards new antidiabetic drugs from fungal endophytes associated with Salvadora oleoides. Decne Med Chem 9:624–632

    Article  CAS  PubMed  Google Scholar 

  • Dineshkumar B, Mitra A, Manjunatha M (2010) A comparative study of alpha amylase inhibitory activities of common antidiabetic plants at Kharagpur 1 block ‎pharm. Int J Green 4(2):115

    Google Scholar 

  • Elavarasi A, Rathna GS, Kalaiselvam M (2012) Taxol producing mangrove endophytic fungi Fusarium oxysporum from Rhizophora Annamalayana. Asian Pac J Trop Biomed S1081–S1085

    Google Scholar 

  • El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba NA, Gali-Muhtasib H (2008) Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncol Rep 19(4):897–904

    CAS  PubMed  Google Scholar 

  • Eyo JE, Ozougwu JC, Echi PC (2011) Hypoglycemic effects of Allium cepa, Allium sativum and Zingiber officinale aqueous extracts on alloxan induced diabetic Rattus novergicus. Med J Islamic World Acad Sci 19(3):121–126

    Google Scholar 

  • Feng Y, Ren F, Niu S, Wang L, Li L (2014) Guanacastane diterpenoids from the plant endophytic fungus Cercospora sp. J Nat Prods 77:873–881

    Article  CAS  Google Scholar 

  • Florence NT, Benoit MZ, Jonas K, Alexandra T, Desire DDP, Pierre K, Theophile D (2014) Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin induced diabetic rats. J Ethnopharmacol 151(2):784–790

    Article  PubMed  Google Scholar 

  • Gangadevi V, Muthumary J (2009) Taxol production by Pestalotiopsis terminaliae, an endophytic fungus of Terminalia arjuna (arjun tree). Biotechnol Appl Biochem 52(1):9–15

    Article  CAS  PubMed  Google Scholar 

  • Ganie SA, Dar TA, Hamid R, Zargar O, Abeer SU, Masood A, Zargar MA (2014) In vitro antioxidant and cytotoxic activities of Arnebia benthamii (Wall ex. G. Don): a critically endangered medicinal plant of Kashmir valley. Oxidative Med Cellular Longevity 2014:1–9

    Article  Google Scholar 

  • Garba A, Mada SB, Ibrahim G, Dauran IA, Hamza AB (2013) Studies on hypoglycemic and hypolipidemic effects of methanolic extract of Stachytarpheta angustifolia (mill) in streptozotocin induced diabetic rats. Asian J Bio Sci 6(3):161–167

    Article  Google Scholar 

  • Ghazanfar K, Ganai BA, Akbar S, Mubashir K, Dar SA, Dar MY, Tantry MA (2014) Antidiabetic activity of Artemisia amygdalina Decne in streptozotocin induced diabetic rats. Biomed Res Int 21:2014

    Google Scholar 

  • Gould GW (1995) Biodeterioration of foods and an overview of preservation in the food and dairy industries. Int Biodeterior Biodegradation 36:267–277

    Article  CAS  Google Scholar 

  • Guo B, Li H, Zhang L (1998) Isolation of the fungus producing vinblastine. J Yunnan Univ 20:214–215

    CAS  Google Scholar 

  • Gupta M, Saxena S, Goyal D (2015) Potential pancreatic lipase inhibitory activity of an endophytic Penicillium species. J Enzyme Inhib Med Chem 30(1):15–21

    Article  CAS  PubMed  Google Scholar 

  • Haire-Joshu D (1996) Management of diabetes mellitus: Perspectives of care across the life span. Mosby-Year Book, St Louis, MO

    Google Scholar 

  • Hou JL, Yong CL, Vrijmoed Jones EBG (2004) A new cytotoxic sterol produced by an endophytic fungus from Castaniopsis fissa at the south China sea coast Chin. Chem Lett 15(4):419–422

    Google Scholar 

  • Huang Z, Yang R, Guo Z, She Z, Lin Y (2010) A new naphtho-γ-pyrone from mangrove endophytic fungus ZSU-H26. Chem Nat Comp 46(1):15–18

    Article  CAS  Google Scholar 

  • Huang JX, Zhang J, Zhang XR, Zhang K, Zhang X (2014) Mucor fragilis as a novel source of the key pharmaceutical agents podophyllotoxin and kaempferol. ‎Pharm Biol 52:1237–1243

    Google Scholar 

  • Ingavat N, Dobereiner J, Wiyakrutta S, Mahidol C, Ruchirawat S, Kittakoop P (2009) Aspergillusol A, an alpha-glucosidase inhibitor from the marine derived fungus Aspergillus aculeatus. J Nat Prods 72:2049–2052

    Article  CAS  Google Scholar 

  • Juan-Badaturuge M, Habtemariam S, Jackson C, Thomas MJ (2009) Antioxidant principles of Tanacetum vulgare L. aerial parts. Nat Prod Commun 4(11):1561–1564

    Google Scholar 

  • Kaul S, Wani M, Dhar KL, Dhar MK (2008) Production and GC-MS trace analysis of methyl eugenol from endophytic isolate of Alternaria from rose. Ann Microbiol 58:443–445

    Article  CAS  Google Scholar 

  • Kobayashi H, Sunaga R, Furihata K, Morisaki N, Iwasaki S (1995) Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp. J Antibiot (Tokyo) 48:42–52

    Article  CAS  Google Scholar 

  • Krishnakumari S, Priya K (2006) Hypolipidemic efficacy of Achyranthes aspera on lipid profile in sesame oil fed rats. Anc Sci Life 25(3–4):49

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar T, Chandrashekar KS (2011) Bauhinia purpurea Linn. A review of its ethnobotany, phytochemical and pharmacological profile. Res J Med Plant 5(4):420–431

    Google Scholar 

  • Kumar AS, Venkatarathanamma V, Suneeta K, Kumari BS (2011) Comparative in vitro screening of α-amylase and α-glucosidase enzyme inhibitory studies in leaves of Annona species. J Pharm Res 4:4431–4434

    Google Scholar 

  • Kumara PM, Soujanya KN, Ravikanth G, Vasudeva R, Ganeshaiah KN, Shaanker RU (2014) Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb). Wight & Arn. Phytomedicine 21:541–546

    Article  CAS  PubMed  Google Scholar 

  • Kundusen S, Gupta M, Mazumder UK (2011) Antitumor activity of Citrus maxima (Burm.) Merr. leaves in ehrlich as cities carcinoma cell treated mice. Pharmacol 2011:1–5

    Google Scholar 

  • Kusari S, Zuhlke S, Spiteller M (2009) An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. J Nat Prods 72(1):2–7

    Article  CAS  Google Scholar 

  • Kusari S, Verma VC, Lamshoeft M, Spiteller M (2012) An endophytic fungus from Azadirachta indica A. Juss. that produces azadirachtin. World J Microbiol Biotechnol 28:1287–1294

    Article  CAS  PubMed  Google Scholar 

  • Kwanghee K, Hyunyul K, Jeunghak K, Sungwon L, Hyunseok K, Sun-A I (2009) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non insulin dependent diabetes mellitus. Phytomedicine 2:14

    Google Scholar 

  • Lee J, Strobel GA, Lob Kovsky E, Clardy JC (1996) Torreyanic acid: A selectively cytotoxic quinine dimer from the endophytic fungus Pestalotiopsis microspore. J Org Chem 61:3232–3233

    Article  CAS  Google Scholar 

  • Li CT, Liu YP, He FC, Li Y (2012) In vitro antioxidant activities of Tussilago farfara, a new record species to Changbai Mountain. Chin J Nat Med 10(4):260–262

    Article  CAS  Google Scholar 

  • Liu J (1995) Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49:57–68

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Luo J, Ye H, Sun Y, Lu Z, Zeng X (2009) Production, characterization and antioxidant activities in vitro of exopolysaccharides from endophytic bacterium Paenibacillus polymyxa EJS-3. Carbohydr Polym 78(2):275–281

    Article  CAS  Google Scholar 

  • Ma C, Jiang D, Wei X (2011) Mutation breeding of Emericella foeniculicola TR21 for improved production of tanshinone IIA. Proc Biochem 46:2059–2063

    Article  CAS  Google Scholar 

  • Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ (2010) Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 39:481–497

    Article  PubMed  PubMed Central  Google Scholar 

  • Mahjoub S, Davari S, Moazezi Z, Qujeq D (2012) Hypolipidemic effects of ethanolic and aqueous extracts of Urtica dioica in rats. World Appl Sci J 17(10):1345–1348

    Google Scholar 

  • Makni M, Fetoui H, Gargouri NK, Garoui EM, Zeghal N (2011) Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan diabetic rats. J Diabetes Complicat 25(5):339–345

    Article  PubMed  Google Scholar 

  • Mallick C, Maiti R, Ghosh D (2006) Comparative study on antihyperglycemic and antihyperlipidemic effects of separate and composite extract of seed of Eugenia jambolana and root of Musa paradisiaca in streptozotocin induced diabetic male albino rat. Iranian J Pharmacol Ther 5(1):27–33

    Google Scholar 

  • Manosroi J, Zaruwa MZ, Manosroi A (2011) Potent hypoglycemic effect of Nigerian antidiabetic medicinal plants. J Complement Integr Med 8(1):1–16

    Google Scholar 

  • Mashentseva AA, Dehaen W, Seitembetov TS, Seitembetova AJ (2011) Comparison of the antioxidant activity of the different Betula pendula Roth. extracts from northern Kazakhstan. J Phytol 3(1):18–25

    Google Scholar 

  • Mbaka GO (2014) The protective role of Sphenocentrum jollyanum leaf extract on beta cells morphology of alloxan treated rabbits. Asian J Med Sci 2(3):195–201

    Google Scholar 

  • McDougall GJ, Kulkarni NN, Stewart D (2009) Berry polyphenols inhibit pancreatic lipase activity in vitro. Food Chem 115(1):193–199

    Article  CAS  Google Scholar 

  • Ming QL, Han T, Li W, Zhang QY, Zhang H, Zheng CJ, Huang F, Rahman K, Qin LP (2012) Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza. Phytomedicine 19:330–333

    Article  CAS  PubMed  Google Scholar 

  • Mishra PD, Verekar SA, Kulkarni AM, Roy SK, Jain S, Balakrishnan A, Vishwakarma R, Deshmukh S (2013) Antiinflammatory and antidiabetic naphthaquinones from an endophytic fungus Dendryphion nanum S. Huges. Indian J Chem 52(B):565–567

    Google Scholar 

  • Mohammed RK, Ibrahim S, Atawodi SE, Eze ED, Suleiman JB, Malgwi IS (2012) The study of the effects of n-butanol fraction of Alchornea cordifolia leaf extract on lipid profile and liver enzymes in streptozotocin induced diabetic rats. Global J Med Plant Res 1(1):1–7

    Google Scholar 

  • Mohammed SI, Chopda MZ, Patil RH, Vishwakarma KS, Maheshwari VL (2016) In vivo antidiabetic and antioxidant activities of Coccinia grandis leaf extract against streptozotocin induced diabetes in experimental rats. Asian Pac J Trop Dis 6(4):298–304

    Article  CAS  Google Scholar 

  • Nithya K, Muthumary J (2009) Growth studies of Colletotrichum gloeosporioides (Penz.) Sacc.–a taxol producing endophytic fungus from Plumeria acutifolia. Indian J Sci Technol 2:14–19

    Google Scholar 

  • Nwodo NJ, Nnadi CO, Ibezim A, Mbah CJ (2014) Plants with Hypolipidemic effects from Nigerian flora. INTECH Open Science 241–44

    Google Scholar 

  • Nwozo S, Adaramoye O, Ajaiyeoba E (2009) Oral administration of extract from Curcuma longa Lowers blood glucose and attenuates alloxan induced hyperlipidemia in diabetic rabbits. Pak J Nutr 8(5):625–628

    Article  Google Scholar 

  • Okokon JE, Antia BS, Udobang JA (2012) Antidiabetic activities of ethanolic extract and fraction of Anthocleista djalonensis. Asian Pac J Trop Biomed 2(6):461–464

    Article  PubMed  PubMed Central  Google Scholar 

  • Ola ARB, Debbab A, Kurtan T, Brotz-Oesterhelt H, Aly AH, Proksch P (2014) Dihydroanthracenone metabolites from the endophytic fungus Diaporthe melonis isolated from Annona squamosal. Tetrahedron Lett 55:3147–3150

    Article  CAS  Google Scholar 

  • Olowu AO, Adeneye AA, Adeyemi OO (2011) Hypoglycemic effect of Ipomoea batatas aqueous leaf and stem extract in normal and streptozotocin induced hyperglycemic rats. J Nat Pharm 2(2):56–61

    Article  CAS  Google Scholar 

  • Onakpoya IJ, O’Sullivan J, Heneghan CJ (2015) The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta analysis of randomized clinical trials. Nutrition 31(5):640–646

    Article  PubMed  Google Scholar 

  • Ooi KL, Muhammad TST, Lim CH, Sulaiman SF (2010) Apoptotic effects of Physalis minima L. chloroform extract in human breast carcinoma T-47D cells mediated by c-myc-, p53-, and caspase-3-dependent pathways. ‎Integr. Cancer Ther 9(1):73–83

    Google Scholar 

  • Ozturk M, Aydogmus-Ozturk F, Duru ME, Topçu G (2007) Antioxidant activity of stem and root extracts of Rhubarb (Rheum ribes): an edible medicinal plant. Food Chem 103(2):623–630

    Article  CAS  Google Scholar 

  • Park BC, Bosire KO, Lee ES, Lee YS, Kim JA (2005) Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett 218(1):81–90

    Article  CAS  PubMed  Google Scholar 

  • Patel DK, Kumar R, Laloo D, Hemalatha S (2012) Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asian Pac J Trop Biomed 2(5):411–420

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patil RH, Krishnan P, Maheshwari VL (2011) Production of lovastatin by wild strains of Aspergillus terreus. Nat Prod Commun 6(2):183–186

    CAS  PubMed  Google Scholar 

  • Patil MP, Patil RH, Maheshwari VL (2015) Biological activities and identification of bioactive metabolite from endophytic Aspergillus flavus L7 isolated from Aegle marmelos. Curr Microbiol 71:39–48

    Article  CAS  PubMed  Google Scholar 

  • Pavana P, Manoharan S, Renju GL, Sethupathy S (2007) Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. ‎J Env Biol 28(4):833–837

    Google Scholar 

  • Peng W, You F, Li XL, Jia M, Zheng CJ, Han T, Qin LP (2013) A new diphenyl ether from the endophytic fungus Verticillium sp. isolated from Rehmannia glutinosa. Chin J Nat Med 11:673–675

    Article  CAS  PubMed  Google Scholar 

  • Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prods 68:1717–1719

    Article  CAS  Google Scholar 

  • Puri SC, Nazir A, Chawla R, Arora R, Riyaz-Ul-Hasan S (2006) The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. ‎J Biotechnol 122:494–510

    Article  CAS  PubMed  Google Scholar 

  • Raghunath R, Radhakrishna A, Angayarkanni J, Palaniswamy M (2012) Production and cytotoxicity studies of lovastatin from Aspergillus niger PN2 an endophytic fungi isolated from Taxus baccata. Int J Appl Biol Pharm Tech 3(3):342–352

    CAS  Google Scholar 

  • Rahimi R, Nikfar S, Larijani B, Abdollahi M (2005) A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 59(7):365–373

    Article  CAS  PubMed  Google Scholar 

  • Ramkumar KM, Manjula C, Sankar L, Suriyanarayanan S, Rajaguru P (2009) Potential in vitro antioxidant and protective effects of Gymnema montanum H. on alloxan induced oxidative damage in pancreatic β-cells, HIT-T15. ‎Food Chem Toxicol 47(9):2246–2256

    Google Scholar 

  • Ratnaweera PB, Williams DE, de Silva ED, Wijesundera RL, Dalisay DS, Andersen RJ (2014) Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, sp. of orchid endemic to Sri Lanka. Mycology 5:23–28

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Rehman S, Shawl AS, Kour A (2008) An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin. Appl Biochem Microbiol 44(2):203–209

    Google Scholar 

  • Rui H, Jiao, Shu X, Jun YL, Hui MG, Hui D, Chen X, Hai LZ, Ren XT (2006) Chetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E105. Organic Lett 8(25):5709–5712

    Google Scholar 

  • Ruma K, Kumar S, Prakash HS (2013) Antioxidant, anti-inflammatory, antimicrobial and cytotoxic properties of fungal endophytes from Garcinia species. Int J Pharm Pharma Sci 5(3):889–897

    Google Scholar 

  • Sadananda TS, Nirupama R, Chaithra K, Govindappa M, Chandrappa CP, Vinay Raghavendra B (2011) Antimicrobial and antioxidant activities of endophytes from Tabebuia argentea and identification of anticancer agent (lapachol). J Med Plants Res 5(16):3643–3652

    CAS  Google Scholar 

  • Saidu AN, Mann A, Onuegbu CD (2012) Phytochemical screening and hypoglycemic effect of aqueous Blighia sapida root bark extract on normoglycemic albino rats. Br J Pharm Res 2(2):89–97

    Article  Google Scholar 

  • Sandesh P, Velu V, Singh RP (2014) Antioxidant activities of tamarind (Tamarindus Indica) seed coat extract using in vitro and in vivo models. J Food Sci Tech 51(9):1965–1973

    Article  CAS  Google Scholar 

  • Saxena A, Vikram NK (2004) Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 10(2):369–378

    Article  PubMed  Google Scholar 

  • Schutz B (2001) Endophytic fungi: a source of novel biologically active secondary metabolites. British Mycological Society, International Symposium Proceedings: bioactive fungal metabolites–impact and exploitation. University of Wales, Swansea. 20

    Google Scholar 

  • Scott LJ, Curran MP, Figgitt DP (2004) Rosuvastatin: a review of its use in the management of dyslipidemia. Am J Cardiovasc Drug 4:117–138

    Article  CAS  Google Scholar 

  • Shanmugasundaram P, Venkataraman S (2006) Hepatoprotective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract. J Ethnopharmacol 104(1):124–128

    Article  CAS  PubMed  Google Scholar 

  • Sharififar F, Dehghn-Nudeh G, Mirtajaldini M (2009) Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem 112(4):885–888

    Article  CAS  Google Scholar 

  • Shi J, Zeng Q, Liu Y, Pan Z (2012) Alternaria sp. MG1, a resveratrol producing fungus: Isolation, identification, and optimal cultivation conditions for resveratrol production. Appl Microbiol Biotechnol 95:369–379

    Article  CAS  PubMed  Google Scholar 

  • Shivanna N, Naika M, Khanum F, Kaul VK (2013) Antioxidant, antidiabetic and renal protective properties of Stevia rebaudiana. J Diabetes Complicat 27(2):103–113

    Article  PubMed  Google Scholar 

  • Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013 CA Cancer. J Clin 63(1):11–30

    Article  Google Scholar 

  • Sigstedt SC, Hooten CJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Steelant WF (2008) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol 32(5):1085–1090

    PubMed  Google Scholar 

  • Sivashanmugam AT, Chatterjee TK (2013) In vitro and in vivo antidiabetic activity of Polyalthia longifolia (Sonner.) Thw. Leaves. Orient Pharm Exp Med 13(4):289–300

    Google Scholar 

  • Sonaimuthu V, Krishnamoorthy S, Johnpaul M (2010) Taxol producing endophytic fungus Fusarium culmorum SV JM072 from medicinal plant of Tinospora cordifolia. J Biotechnol 150:S571–S576

    Google Scholar 

  • Sowndhararajan K, Kang SC (2013) Free radical scavenging activity from different extracts of leaves of Bauhinia vahlii Wight & Arn. Saudi J Biol Sci 20(4):319–325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sreerama YN, Takahashi Y, Yamaki K (2012) Phenolic antioxidants in some Vigna species of legumes and their distinct inhibitory effects on -glucosidase and pancreatic lipase activities. J Food Sci 77(9):C927–C933

    Article  CAS  PubMed  Google Scholar 

  • Stevic T, Savikin K, Zdunic G, Stanojkovic T, Juranic Z, Jankovic T, Menkovic N (2010) Antioxidant, cytotoxic, and antimicrobial activity of Alnus incana (L.) ssp. Incana moench and A. viridis (Chaix) DC ssp. viridis extracts. J Med Food 13(3):700–704

    Article  CAS  PubMed  Google Scholar 

  • Stierle AA, Stierle DB, Bugni T (2001) Sequoiatones, C-F constituents of the redwood endophytes. J Nat Prods 64(10):1350–1353

    Article  CAS  Google Scholar 

  • Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products microbiol. Microbiol Mol Biol Rev 67(4):491–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Strobel GA, Hess WM, Li JY, Ford E, Sears J, Sidhu RS, Summerell B (1997) Pestalotropsis guepinii, a taxol producing endophyte of the Wollemi pine, Wollemia nobilis. Aust J Bot 45:1073–1082

    Article  CAS  Google Scholar 

  • Strobel G, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67:257–268

    Article  CAS  PubMed  Google Scholar 

  • Subash AK, Augustine A (2012) Hypolipidemic effect of methanol fraction of Aconitum heterophyllum wall ex Royle and the mechanism of action in diet induced obese rats. J Adv Pharm Technol Res 3(4):224–228

    Article  PubMed  PubMed Central  Google Scholar 

  • Sun Y, Xun K, Wang Y, Chen X (2009) A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs 20:757–769

    Article  CAS  PubMed  Google Scholar 

  • Sundarrajan T, Raj Kumar T, Udhayakumar E, Arunachalam G (2010) Hypolipidemic activity of Pithecellobium dulce Bench Triton Wr–1339 induced hyperlipidemic rats. Int J Chem Pharm Sci 1:50–53

    Google Scholar 

  • Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448–459

    Article  CAS  PubMed  Google Scholar 

  • Tsumbu CN, Deby-Dupont G, Tits M, Angenot L, Franck T, Serteyn D, Mouithys-Mickalad A (2011) Antioxidant and antiradical activities of Manihot esculenta Crantz (Euphorbiaceae) leaves and other selected tropical green vegetables investigated on lipoperoxidation and phorbol-12-myristate-13-acetate (PMA) activated monocytes. Nutrients 3(9):818–838

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uddin SJ, Grice ID, Tiralongo E (2011) Cytotoxic effects of Bangladeshi medicinal plant extracts. Evid Based Complement Alternat Med 2011:1–8

    Article  Google Scholar 

  • Uma SR, Ramesha BT, Ravikanth G, Rajesh PG, Vasudeva R, Ganeshaiah KN (2008) Chemical profiling of Nothapodytes nimmoniana for camptothecin, an important anticancer alkaloid: towards the development of a sustainable production system in bioactive molecules and medicinal plants. In: Ramawat KG, Merillon JM (eds) bioactive molecules and medicinal plants. Springer, Berlin, pp 197–213

    Google Scholar 

  • Venkadeswaran K, Muralidharan AR, Annadurai T, Ruban VV, Sundararajan M, Anandhi R, Geraldine P (2014) Antihypercholesterolemic and antioxidative potential of an extract of the plant, Piper beetle, and its active constituent, eugenol, in Triton WR-1339-induced hypercholesterolemia in experimental rats. Evid Based Complement Alternat Med 2014:1–11

    Article  Google Scholar 

  • Vinodhini D, Agastian P (2013) Berberine production by endophytic fungus Fusarium solani from Coscinium fenestratum. Int J Pharm Biol Sci 4:1239–1245

    Google Scholar 

  • Wagenaar MM, Corwin J, Strobel G, Clardy J (2000) Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prods 63:1692–1695

    Article  CAS  Google Scholar 

  • Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents I The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminate. J Am Chem Soc 88(16):3888–3890

    Article  CAS  Google Scholar 

  • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents VI The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93(9):2325–2327

    Article  CAS  PubMed  Google Scholar 

  • Weaver BA (2014) How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 25(18):2677–2681

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Wei QG, Liang ZL, Zhuo YH (2013) Antiproliferative effects of Atractylis lancea (Thunb.) DC. via downregulation of the c-myc/hTERT/telomerase pathway in Hep-G2 Cells. Asian Pac J Cancer Prev 14:6363–6367

    Article  Google Scholar 

  • Weng Y, Yu L, Cui J, Zhu YR, Guo C, Wei G, Yang ZF (2014) Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. J Ethnopharmacol 152(3):553–560

    Article  CAS  PubMed  Google Scholar 

  • Xu YM, Espinosa-Artiles P, Liu MX, Arnold AE, Gunatilaka AA (2013) Secoemestrin D, a cytotoxic epitetrathiodioxopiperizine, and emericellenes AE, five sesterterpenoids from Emericella sp. AST0036, a fungal endophyte of Astragalus lentiginosus. J Nat Prods 76:2330–2336

    Article  CAS  Google Scholar 

  • Yang X, Strobel GA, Stierle A, Hess WH, Lee J (1994) A fungal endophyte tree relationship: Phoma sp. in Taxus wallachiana. Plant Sci 102:1–9

    Article  CAS  Google Scholar 

  • Yang X, Zhang L, Guo B, Guo S (2004) Preliminary study of a vincristine producing endophytic fungus isolated from leaves of Catharanthus roseus. Chin Tradit Herbal Drugs 35:79–81

    CAS  Google Scholar 

  • Yogisha S, Raveesha KA IV (2010) Dipeptidyl peptidase IV inhibitory activity of Mangifera indica. J Nat Prods 3:76–79

    Google Scholar 

  • Yong L, Chongming W, Dong L, Peter P, Peng G, Wenhan L (2013) Chartarlactams AP, phenylspirodrimanes from the sponge associated fungus Stachybotrys chartarum with antihyperlipidemic activities. J Nat Prods 77(1):138–147

    Google Scholar 

  • Yunianto P, Rusman Y, Saepudin E, Suwarso WP, Sumaryano W (2014) Alkaloid (meleaine and chrysogine) from endophytic fungi (Penicillium sp.) of L. Pak J Biol Sci 17:667–674

    Article  PubMed  Google Scholar 

  • Zhang L, Guo B, Li H, Zeng S, Shao H, Gu S, Wei R (2000) Preliminary study on the isolation of endophytic fungus of Catharanthus roseus and its fermentation to produce products of therapeutic value Chin Tradit Herbal. Drugs 31:805–807

    CAS  Google Scholar 

  • Zhang Q, Wei X, Wang J (2012) Phillyrin produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspense. Fitoterapia 83:1500–1505

    Article  CAS  PubMed  Google Scholar 

  • Zhao J, Fu Y, Luo M, Zu Y, Wang W, Zhao C, Gu C (2012) Endophytic fungi from pigeon pea (Cajanus cajan (L.) Millsp.) produce antioxidant cajaninstilbene acid. J Agric Food Chem 60:4314–4319

    Article  CAS  PubMed  Google Scholar 

  • Zhao J, Li C, Wang W, Zhao C, Luo M (2013) Hypocrea lixii, novel endophytic fungi producing anticancer agent cajanol, isolated from pigeon pea (Cajanus cajan [L.] Millsp.). J Appl Microbiol 115:102–113

    Article  CAS  PubMed  Google Scholar 

  • Zhou K, Wang H, Mei W, Li X, Luo Y, Dai H (2011) Antioxidant activity of papaya seed extracts. Molecules 16(8):6179–6192

    Article  CAS  PubMed  Google Scholar 

  • Zlobin AA, Martinson EA, Litvinets SG, Ovechkina IA, Durnev EA, Ovodova RG (2012) Pectin polysaccharides of rowan Sorbus aucuparia L Russ. J Bioorg Chem 38(7):702–706

    Article  CAS  Google Scholar 

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Acknowledgements

The financial assistance provided by SERB, DST, New Delhi, in terms of fast track grant (File No. SR/FT/LS43/2012) to RHP, the fellowship from UGC, New Delhi under its Maulana Azad National Fellowship for Minorities (MANF) scheme (F1-17.7/2012-13/MANF-2012-13-MUS-MAH-13068/[SA-III/Website]) to SIM and financial support from UGC, New Delhi and DST, New Delhi for strengthening the research facilities in the School under the SAP-DRS (F.4-23/2015/DRS-II [(SAP II]) and FIST (SR/FST/LSI-433/2010) programs, respectively are gratefully acknowledged.

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Authors and Affiliations

  1. School of Life Sciences, North Maharashtra University, Jalgaon, 425001, MS, India

    Shahid Iqbal Mohammed & Vijay Laxminarayan Maheshwari

  2. Department of Microbiology and Biotechnology, R. C. Patel Arts, Commerce and Science College, Karvand Naka, Shirpur, MS, India

    Mohini Panditrao Patil & Ravindra Himmatrao Patil

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  1. Shahid Iqbal Mohammed
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  2. Mohini Panditrao Patil
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  3. Ravindra Himmatrao Patil
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  4. Vijay Laxminarayan Maheshwari
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Correspondence to Vijay Laxminarayan Maheshwari .

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  1. Department of Botany and Microbiology, Gurukul Kangri University, Haridwar, India

    Dinesh K. Maheshwari

  2. Division of Microbiology, Indian Agricultural Research, New Delhi, India

    K. Annapurna

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Mohammed, S.I., Patil, M.P., Patil, R.H., Maheshwari, V.L. (2017). Endophytes: Potential Source of Therapeutically Important Secondary Metabolites of Plant Origin. In: Maheshwari, D., Annapurna, K. (eds) Endophytes: Crop Productivity and Protection. Sustainable Development and Biodiversity, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-319-66544-3_10

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