Skip to main content
SpringerLink
Log in

Plant Derived Essential Oils Against Aedes aegypti L. and Their Biotechnological Production

  • Chapter
Medicinal Plants and Environmental Challenges

Abstract

Aedes aegyti L. is the main vector of important viruses like Dengue, Yellow, Zika and Chikungunya fevers. In many countries, these diseases are considered as great public health problems due to the serious consequences they can cause such as Guillain-Barré syndrome, neurological disorders and internal hemorrhagic problems, which may lead to death. The transmission of these diseases occurs through the bite of infected female of A. aegypti. According to World Health Organization, the major way to avoid the spread of these diseases is to control the vector by using larvicides and insecticides products. Many efforts have been done to find natural products that can be used to eliminate different phases of the life cycle of this mosquito. Among these, essential oils are recognized as important plant-derived products to control A. aegypti. Essential oils are complex mixture of mono, sesquiterpenes and phenylpropanoids and normally have a nice odor. Several studies have shown the larvicidal and insecticides properties of essential oils in plants belonging to different families. The literature studies indicated that in most of the cases monoterpenes like geraniol and citronellol, and phenylpropanoids; eugenol were the main components of essential oils that can control A. aegypti spread. In vitro studies suggested that composition and production of essential oils could be manipulated by the use of different concentrations and combinations of growth regulators and elicitors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akhtar Y, Pages E, Stevens A, Bradbury R, da Camara CAG, Isman MB (2012) Effect of chemical complexity of essential oils on feeding deterrence in larvae of the cabbage looper. Physiol Entomol 37(1):81–91. doi:10.1111/j.1365-3032.2011.00824.x

    Article  CAS  Google Scholar 

  • Barnard DR (1999) Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol 36(5):625–629. doi:10.1093/jmedent/36.5.625

    Article  CAS  PubMed  Google Scholar 

  • Baser KHC, Buchbauer G (2015) Handbook of essential oils: science, technology, and applications, 2nd edn. CRC Press, Boca Raton

    Book  Google Scholar 

  • Baskar K, Sudha V, Nattudurai G, Ignacimuthu S, Duraipandiyan V, Jayakumar M et al (2017) Larvicidal and repellent activity of the essential oil from Atalantia monophylla on three mosquito vectors of public health importance, with limited impact on non-target zebra fish. Physiol Mol Plant Pathol. doi:10.1016/j.pmpp.2017.03.002

    Article  Google Scholar 

  • Benelli G (2015) Research in mosquito control: current challenges for a brighter future. Parasitol Res 114(8):2801–2805

    Article  Google Scholar 

  • Bohbot JD, Dickens JC (2010) Insect repellents: modulators of mosquito odorant receptor activity. PLoS ONE 5(8):e12138

    Article  Google Scholar 

  • Boix YF, Victório CP, Lage CLS, Kuster RM. (2010) Volatile compounds from Rosmarinus officinalis L. and Baccharis dracunculifolia DC. growing in southeast coast of Brazil. Quimica Nova, 33(2), 255–257

    Article  CAS  Google Scholar 

  • Carroll JF, Tabanca N, Kramer M, Elejalde NM, Wedge DE, Bernier UR et al (2011) Essential oils of Cupressus funebris, Juniperus communis, and J. chinensis (Cupressaceae) as repellents against ticks (Acari: Ixodidae) and mosquitoes (Diptera: Culicidae) and as toxicants against mosquitoes. J Vector Ecol 36(2):258–268. doi:10.1111/j.1948-7134.2011.00166.x

    Article  PubMed  Google Scholar 

  • Choochote W, Chaithong U, Kamsuk K, Jitpakdi A, Tippawangkosol P, Tuetun B et al (2007) Repellent activity of selected essential oils against Aedes aegypti. Fitoterapia 78(5):359–364. doi:10.1016/j.fitote.2007.02.006

    Article  CAS  PubMed  Google Scholar 

  • Clem JR, Havemann DF, Raebel MA (1993) Insect repellent (N, N-diethyl-m-toluamide) cardiovascular toxicity in an adult. Ann Pharmacother 27(3):289–293

    Article  CAS  Google Scholar 

  • Colovic MB, Krstic DZ, Lazarevic-Pasti TD, Bondzic AM, Vasic VM (2013) Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11(3):315–335

    Article  CAS  Google Scholar 

  • Corbel V, Stankiewicz M, Pennetier C, Fournier D, Stojan J, Girard E, Lapied B (2009) Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet. BMC Biol 7(1):47

    Article  Google Scholar 

  • Darbro JM, Muzari MO, Giblin A, Adamczyk RMA, Ritchie AS, Devine GJ (2017) Reducing biting rates of Aedes aegypti with metofluthrin: investigations in time and space. Parasites Vectors 10:69. doi:10.1186/s13071-017-2004-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Demirci B, Tsikolia M, Bernier UR, Agramonte NM, Alqasoumi SI, Al-Yahya MA et al (2013) Phoenix dactylifera L. spathe essential oil: Chemical composition and repellent activity against the yellow fever mosquito. Acta Trop 128(3):557–560. doi:10.1016/j.actatropica.2013.08.003

    Article  CAS  PubMed  Google Scholar 

  • Dias CN, Moraes DFC (2014) Essential oils and their compounds as Aedes aegypti L. (Diptera: Culicidae) larvicides: review. Parasitol Res 113:565–592. doi:10.1007/s00436-013-3687-6

    Article  PubMed  Google Scholar 

  • Dickens JC, Bohbot JD (2013) Mini review: mode of action of mosquito repellents. Pestic Biochem Physiol 106(3):149–155

    Article  CAS  Google Scholar 

  • Edwin ES, Vasantha-Srinivasan P, Senthil-Nathan S et al (2016) A. Anti-dengue efficacy of bioactive andrographolide from Andrographis paniculata (Lamiales: Acanthaceae) against the primary dengue vector Aedes aegypti (Diptera: Culicidae). Acta Trop 163:167–178

    Article  CAS  Google Scholar 

  • El-Bakry AA, Abdel-Salam AM (2012) Regeneration from embryogenic callus and suspension cultures of the wild medicinal plant Cymbopogon schoenanthus. Afr J Biotech 11(43):10098–10107

    CAS  Google Scholar 

  • El-Wakeil NE (2013) Botanical pesticides and their mode of action. Gesunde Pflanzen 65(4):125–149

    Article  CAS  Google Scholar 

  • Enan E (2001) Insecticidal activity of essential oils: octopaminergic sites of action. Comp Biochem Physiol C: Toxicol Pharmacol 130(3):325–337

    CAS  Google Scholar 

  • Gillij YG, Gleiser RM, Zygadlo JA (2008) Mosquito repellent activity of essential oils of aromatic plants growing in Argentina. Biores Technol 99(7):2507–2515. doi:10.1016/j.biortech.2007.04.066

    Article  CAS  Google Scholar 

  • Govindaraj S, Kumari BD, Cioni PL, Flamini G (2008) Mass propagation and essential oil analysis of Artemisia vulgaris. J Biosci Bioeng 105(3):176–183

    Article  CAS  Google Scholar 

  • Hegedus D, Erlandson M, Gillott C, Toprak U (2009) New insights into peritrophic matrix synthesis, architecture, and function. Annu Rev Entomol 54:285–302

    Article  CAS  Google Scholar 

  • Jantan I, Mohd Z (1999) Development of environment-friendly insect repellents from the leaf oils of selected Malaysian plants. ASIAN Review of Biodiversity and Environmental Conservation, Nov-Dec, pp 1–7

    Google Scholar 

  • Kerdudo A, Gonnot V, Ellong EN, Boyer L, Chandre F, Adenet S et al (2016) Composition and bioactivity of Pluchea carolinensis (Jack.) G. essential oil from Martinique. Ind Crops Prod 89:295–302. doi:10.1016/j.indcrop.2016.04.076

    Article  CAS  Google Scholar 

  • Khanikor B, Parida P, Yadav RNS, Bora D (2013) Comparative mode of action of some terpene compounds against octopamine receptor and acetyl cholinesterase of mosquito and human system by the help of homology modeling and docking studies. J Appl Pharm Sci 3(2):6

    Google Scholar 

  • Kiplang’at K, Mwangi RW (2014) Synergistic repellent activity of plant essential oils against Aedes aegypti on rabbit Skin. Intern J Mosq Res 1(4):55–59

    Google Scholar 

  • Klowden MJ (2007) Making generalizations about vectors: is there a physiology of “the mosquito”? Entomol Res 37119110:1–13. doi:10.1111/j.1748-5967.2007.00044.x

    Article  Google Scholar 

  • Kostyukovsky M, Rafaeli A, Gileadi C, Demchenko N, Shaaya E (2002) Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: possible mode of action against insect pests. Pest Manag Sci 58(11):1101–1106

    Article  CAS  Google Scholar 

  • Kumar S, Wahab N, Warikoo R (2011) Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L. Asian Pacific J Trop Biomed 1(2):85–88. doi:10.1016/S2221-1691(11)60001-4

    Article  Google Scholar 

  • Kwon HW, Kim SI, Chang KS, Clark JM, Ahn YJ (2011) Enhanced repellency of binary mixtures of Zanthoxylum armatum seed oil, vanillin, and their aerosols to mosquitoes under laboratory and field conditions. J Med Entomol 48(1):61–66

    Article  CAS  Google Scholar 

  • Leal WS, Uchida K (1998) Application of GC-EAD to the determination of mosquito repellents derived from a plant, Cymbopogon citratus. J Asia-Pacific Entomol 1(2):217–221

    Article  Google Scholar 

  • Lupi E, Hatz C, Schlagenhauf P (2013) The efficacy of repellents against Aedes, Anopheles, Culex and Ixodes spp.—a literature review. Travel Med Infect Dis 11(6):374–411. doi:10.1016/j.tmaid.2013.10.005

    Article  PubMed  Google Scholar 

  • Maday E, Szoke E, Zs Muskath, Lemberkovics E (1999) A study of the production of essential oils in chamomile hairy root cultures. Eur J Drug Metab Pharmacokinet 24(4):303–308

    Article  CAS  Google Scholar 

  • Maia M, Moore SJ (2011) Plant-based insect repellents: a review of their efficacy, development and testing. Malar J 10(Suppl 1):S11. doi:10.1186/1475-2875-10-S1-S11

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malik S, Kumar R, Vats SK, Bhushan S, Sharma M, Ahuja PS (2009) Regeneration in Rheum emodi Wall.: a step towards conservation of an endangered medicinal plant species. Eng Life Sci 2:130–134

    Article  Google Scholar 

  • Malik S, Sharma S, Sharma M, Ahuja PS (2010) Direct shoot regeneration from intact leaves of Arnebia euchroma (Royle) Johnston using thidiazuron. Cell Biol Int 34(5):537–542

    Article  CAS  Google Scholar 

  • Malik S, Sharma M, Ahuja PS (2016) An efficient and economic method for in vitro propagation of Arnebia euchroma using liquid culture system. Am J Biotechnol Med Res 1(1):19–25

    Article  Google Scholar 

  • Mathew R, Sankar PD (2012) Effect of methyl jasmonate and chitosan on growth characteristics of Ocimum basilicum L., Ocimum sanctum L. and Ocimum gratissimum L. cell suspension cultures. Afr J Biotech 11(21):4759–4766

    CAS  Google Scholar 

  • Matsuda BM, Surgeoner GA, Heal JD, Tucker AO, Maciarello MJ. (1996) Essential oil analysis and field evaluation of the citrosa plant Pelargonium citrosum as a repellent against populations of Aedes mosquitoes. J Am Mosq Control Assoc 1, 12(1), 69–74

    Google Scholar 

  • Müller GC, Junnila A, Butler J, Kravchenko VD, Revay EE, Weiss RW, Schlein Y (2009) Efficacy of the botanical repellents geraniol, linalool, and citronella against mosquitoes. J Vector Ecol 34(1):2–8. doi:10.1111/j.1948-7134.2009.00002.x

    Article  PubMed  Google Scholar 

  • Nerio LS, Olivero-Verbel J, Stashenko E (2010) Repellent activity of essential oils: a review. Biores Technol 101(1):372–378. doi:10.1016/j.biortech.2009.07.048

    Article  CAS  Google Scholar 

  • Otero ALC, Méndez LYV, Kouznetsov VV (2014) Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever. Eur J Med Chem 78:392–400

    Article  Google Scholar 

  • Pellegrino M, Steinbach N, Stensmyr MC, Hansson BS, Vosshall LB (2011) A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor. Nature 478(7370):511–514

    Article  CAS  Google Scholar 

  • Pohlit A, Lopes N, Gama R, Tadei W, de Andrade Neto V (2011) Patent literature on mosquito repellent inventions which C contain plant essential oils—a review. Planta Med 77(6):598–617. doi:10.1055/s-0030-1270723

    Article  CAS  PubMed  Google Scholar 

  • Prajapati V, Tripathi A, Aggarwal K, Khanuja S (2005) Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Biores Technol 96(16):1749–1757. doi:10.1016/j.biortech.2005.01.007

    Article  CAS  Google Scholar 

  • Ravi Kiran S, Sita Devi P (2007) Evaluation of mosquitocidal activity of essential oil and sesquiterpenes from leaves of Chloroxylon swietenia DC. Parasitol Res 101(2):413–418. doi:10.1007/s00436-007-0485-z

    Article  PubMed  Google Scholar 

  • Rehman JU, Ali A, Khan IA (2014) Plant based products: use and development as repellents against mosquitoes: A review. Fitoterapia 95:65–74

    Article  CAS  Google Scholar 

  • Rodrigues M, Festucci-Buselli RA, Silva LC, Otoni WC (2014) Azadirachtin biosynthesis induction in Azadirachta indica A. Juss cotyledonary calli with elicitor agents. Braz Arch Biol Technol 57(2):155–162

    Article  CAS  Google Scholar 

  • Santos MRA, Guimarães MCM, Paz ES, Magalhães GMO, Souza CA, Smozinski CV, Nogueira WO (2016) Induction and growth pattern of callus from Piper permucronatum leaves. Rev. Bras. Pl. Med. 18(1):142–148

    Article  Google Scholar 

  • Silva S, Sato A, Lage CLS, Gil RAS, Azevedo DA, Esquibel MA. (2005a). Essential Oil composition of Melissa officinalis L. in vitro produced under the influence of growth regulators. Journal Brazillian Chemical Society, 16(6B): 1387–1390

    Article  Google Scholar 

  • Silva S, Sato A, Lagea CLS et al (2005b) Essential oil composition of Melissa officinalis L. in vitro produced under the influence of growth regulators. J Braz Chem Soc 16(6B):1387–1390

    Article  Google Scholar 

  • Sritabutra D, Soonwera M, Waltanachanobon S, Poungjai S (2011) Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton and Harrion. Asian Pacific J Trop Biomed 1(1):S124–S128. doi:10.1016/S2221-1691(11)60138-X

    Article  Google Scholar 

  • Stanczyk NM, Brookfield JF, Ignell R, Logan JG, Field LM (2010) Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function. Proc Natl Acad Sci 107(19):8575–8580

    Article  CAS  Google Scholar 

  • Tikar SN, Mendki MJ, Chandel K, Parashar BD, Prakash S (2008) Susceptibility of immature stages of Aedes (Stegomyia) aegypti vector of dengue and chikungunya to insecticides from India. Parasitol Res 102(5):907–913. doi:10.1007/s00436-007-0848-5

    Article  CAS  PubMed  Google Scholar 

  • Tisgratog R, Sanguanpong U, Grieco JP, Ngoen-Kluan R, Chareonviriyaphap T (2016) Plants traditionally used as mosquito repellents and the implication for their use in vector control. Acta Trop 157:136–144. doi:10.1016/j.actatropica.2016.01.024

    Article  PubMed  Google Scholar 

  • Trongtokit Y, Rongsriyam Y, Komalamisra N, Apiwathnasorn C (2005) Comparative repellency of 38 essential oils against mosquito bites. Phytother Res 19(4):303–309. doi:10.1002/ptr.163

    Article  CAS  PubMed  Google Scholar 

  • Vasconcelos PFC, Rosa APAT, Pinheiro FP, Rodrigues SG, Rosa EST, Cruz CR, Rosa JFT (1999) Aedes aegypti, Dengue and re-urbanization of yellow fever in Brazil and other South American countries—past and present situation and future perspectives. Dengue Bulletim 33:55–66

    Google Scholar 

  • Wang Z, Song J, Chen J, Song Z, Shang S, Jiang Z, Han Z (2008) Qsar study of mosquito repellents from terpenoid with a six-member-ring. Bioorg Med Chem Lett 18(9):2854–2859

    Article  CAS  Google Scholar 

  • WHO (2009) Temephos in drinking-water: use for vector control in drinking-water sources and containers. WHO, Geneva

    Google Scholar 

  • WHO (2012a) Impact of dengue. Global alert and response (GAR). http://www.who.int/csr/disease/dengue/impact/en/index.html. Accessed 15 Jan 2017

  • WHO (2012b) Dengue and severe dengue. Factsheet no. 117. http://www.who.int/mediacentre/factsheets/fs117/en/. Accessed 15 Jan 2017

  • WHO (2016) Surveillance for Zika virus infection, microcephaly and Guillain Barré syndrome.http://www.who.int/csr/resources/publications/zika/surveillance/en/. Accessed 25 Jan 2017

  • WHO (2017a) Diseases out break news. http://www.who.int/csr/don/26-may-2017-zika-ind/en/. Accessed 27 Jan 2017

  • WHO (2017b) Zika vírus county classification scheme. http://www.who.int/csr/resources/publications/zika/classification/en/. Accessed 30 April 2017

  • Zhang Y, Zhao B, Roy S, Saha TT, Kokoza VA, Li M, Raikhel AS (2016) MicroRNA-309 targets the homebox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti. Proc Natl Acad Sci USA 113(33):E4828–E4836. doi:10.1073/pnas.1609792113

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao J, Davis LC, Verpoorte R (2005) Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 23(4):283–333

    Article  CAS  Google Scholar 

  • Zhou J, Ma G, Bunn E, Zhang X (2007) In vitro shoot organogenesis from Pelargonium X Citrosum Vanleenii leaf and petiole explants. Floric Ornamental Biotechnology 1(2):147–149

    Google Scholar 

Download references

Acknowledgements

Authors would like to acknowledge Fundação de Amparo à Pesquisa e Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA), Sao Luis, Maranhao.

Author information

Authors and Affiliations

  1. Department of Pharmacy, Biological and Health Sciences Center, Federal University of Maranhao, Sao Luis, MA, 65085-580, Brazil

    Clarice Noleto Dias, Ludmilla Santos Silva de Mesquita & Denise Fernandes Coutinho

  2. Graduate Program in Health Sciences, Biological and Health Sciences Center, Federal University of Maranhao, Sao Luis, MA, 65085-580, Brazil

    Sonia Malik

Authors
  1. Clarice Noleto Dias
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ludmilla Santos Silva de Mesquita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Denise Fernandes Coutinho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sonia Malik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sonia Malik .

Editor information

Editors and Affiliations

  1. Department of Medicinal Plants, Arak University, Arak, Iran

    Mansour Ghorbanpour

  2. Amity Institute of Microbial Technology, Amity University, Noida, Uttar Pradesh, India

    Ajit Varma

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Dias, C.N., de Mesquita, L.S.S., Coutinho, D.F., Malik, S. (2017). Plant Derived Essential Oils Against Aedes aegypti L. and Their Biotechnological Production. In: Ghorbanpour, M., Varma, A. (eds) Medicinal Plants and Environmental Challenges. Springer, Cham. https://doi.org/10.1007/978-3-319-68717-9_19

Download citation

Publish with us

Policies and ethics

Search

Navigation