Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep

Puttabyatappa, Muraly; Padmanabhan, Vasantha

doi:10.1007/978-3-319-70178-3_25

Muraly Puttabyatappa⁷ &
Vasantha Padmanabhan⁷

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1043))

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17 Citations

Abstract

Insulin resistance, a common feature of metabolic disorders such as obesity, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome, is a risk factor for development of diabetes. Because sex hormones orchestrate the establishment of sex-specific behavioral, reproductive, and metabolic differences, a role for them in the developmental origin of insulin resistance is also to be expected. Female sheep exposed to male levels of testosterone during fetal life serve as an excellent translational model for delineating programming of insulin resistance. This chapter summarizes the ontogeny of insulin resistance, the tissue-specific changes in insulin sensitivity, and the various factors that are involved in the programming and maintenance of the insulin resistance in adult female sheep that were developmentally exposed to fetal male levels of testosterone during the sexual-differentiation window.

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This work was supported by NIH P01 HD44232.

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Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
Muraly Puttabyatappa & Vasantha Padmanabhan

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Franck Mauvais-Jarvis

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Puttabyatappa, M., Padmanabhan, V. (2017). Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_25

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Prenatal Testosterone Programming of Insulin Resistance in the Female Sheep