Skip to main content

Transjugular Intrahepatic Portosystemic Shunt (TIPS) and Portal Hypertension

  • Chapter
  • First Online:
IR Playbook
  • 2875 Accesses

Abstract

Chronic liver disease results in approximately 38,000 deaths a year, making it the 12th leading cause of mortality in the United States. Progressive liver disease results in portal hypertension, which leads to sequelae such as ascites, variceal hemorrhage, hepatic hydrothorax, and hepatorenal syndrome. Management includes screening for esophageal varices and treating complications of portal hypertension with medical, endoscopic, and interventional therapies. The transjugular intrahepatic portosystemic shunt (TIPS) has been proven effective in treating variceal hemorrhage, refractory ascites, and other manifestations of portal hypertension. Clinical indications, patient selection, technical considerations, post-procedure management, and complications are discussed in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. CDCData [Internet]. [cited 2017 Feb 3]. Available from: https://www.cdc.gov/nchs/data/nvsr/nvsr65/nvsr65_04.pdf.

  2. Berzigotti A, Seijo S, Reverter E, Bosch J. Assessing portal hypertension in liver diseases. Expert Rev Gastroenterol Hepatol. 2013;7(2):141–55.

    Article  CAS  PubMed  Google Scholar 

  3. Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology (Baltimore, MD). 2004;39(2):280–2.

    Article  Google Scholar 

  4. Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology (Baltimore, MD). 1985;5(3):419–24.

    Article  CAS  Google Scholar 

  5. Merkel C, Bolognesi M, Bellon S, Zuin R, Noventa F, Finucci G, et al. Prognostic usefulness of hepatic vein catheterization in patients with cirrhosis and esophageal varices. Gastroenterology. 1992;102(3):973–9.

    Article  CAS  PubMed  Google Scholar 

  6. Berzigotti A, Rossi V, Tiani C, Pierpaoli L, Zappoli P, Riili A, et al. Prognostic value of a single HVPG measurement and Doppler-ultrasound evaluation in patients with cirrhosis and portal hypertension. J Gastroenterol. 2011;46(5):687–95.

    Article  PubMed  Google Scholar 

  7. Merkel C, Marin R, Sacerdoti D, Donada C, Cavallarin G, Torboli P, et al. Long-term results of a clinical trial of nadolol with or without isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Hepatology (Baltimore, MD). 2000;31(2):324–9.

    Article  CAS  Google Scholar 

  8. Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R, et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005;353(21):2254–61.

    Article  CAS  PubMed  Google Scholar 

  9. Bosch J, Pizcueta P, Feu F, Fernández M, García-Pagán JC. Pathophysiology of portal hypertension. Gastroenterol Clin N Am. 1992;21(1):1–14.

    CAS  Google Scholar 

  10. Gupta TK, Chen L, Groszmann RJ. Pathophysiology of portal hypertension. Clin Liver Dis. 1997;1(1):1–12.

    Article  CAS  PubMed  Google Scholar 

  11. García-Pagán J-C, Gracia-Sancho J, Bosch J. Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatol. 2012;57(2):458–61.

    Article  PubMed  Google Scholar 

  12. Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology (Baltimore, MD). 2006;43(2 Suppl 1):S121–31.

    Article  CAS  Google Scholar 

  13. Ginés P, Quintero E, Arroyo V, Terés J, Bruguera M, Rimola A, et al. Compensated cirrhosis: natural history and prognostic factors. Hepatology (Baltimore, MD). 1987;7(1):122–8.

    Article  Google Scholar 

  14. Ginès P, Fernández-Esparrach G, Arroyo V, Rodés J. Pathogenesis of ascites in cirrhosis. Semin Liver Dis. 1997;17(3):175–89.

    Article  PubMed  Google Scholar 

  15. Solà E, Ginès P. Renal and circulatory dysfunction in cirrhosis: current management and future perspectives. J Hepatol. 2010;53(6):1135–45.

    Article  PubMed  Google Scholar 

  16. AASLDPracticeGuidelineAsciteDuetoCirrhosisUpdate2012Edition4_.pdf [Internet]. [cited 2017 Mar 1]. Available from: http://www.aasld.org/sites/default/files/guideline_documents/AASLDPracticeGuidelineAsciteDuetoCirrhosisUpdate2012Edition4_.pdf.

  17. Grace ND. Prevention of initial variceal hemorrhage. Gastroenterol Clin N Am. 1992;21(1):149–61.

    CAS  Google Scholar 

  18. Smith JL, Graham DY. Variceal hemorrhage: a critical evaluation of survival analysis. Gastroenterology. 1982;82(5 Pt 1):968–73.

    PubMed  CAS  Google Scholar 

  19. Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD. The practice guidelines Committee of the American Association for the study of liver diseases and the practice parameters Committee of the American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007;102(9):2086–102.

    Article  PubMed  Google Scholar 

  20. Sharma M, Rameshbabu CS. Collateral pathways in portal hypertension. J Clin Exp Hepatol. 2012;2(4):338–52.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Rösch J, Hanafee WN, Snow H. Transjugular portal venography and radiologic portacaval shunt: an experimental study. Radiology. 1969;92(5):1112–4.

    Article  PubMed  Google Scholar 

  22. Salerno F, Cammà C, Enea M, Rössle M, Wong F. Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data. Gastroenterology. 2007;133(3):825–34.

    Article  CAS  PubMed  Google Scholar 

  23. Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 2010;362(9):823–32.

    Article  CAS  PubMed  Google Scholar 

  24. Vangeli M, Patch D, Burroughs AK. Salvage tips for uncontrolled variceal bleeding. J Hepatol. 2002;37(5):703–4.

    Article  CAS  PubMed  Google Scholar 

  25. Patidar KR, Sydnor M, Sanyal AJ. Transjugular intrahepatic portosystemic shunt. Clin Liver Dis. 2014;18(4):853–76.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Boyer TD, Haskal ZJ. The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension: update 2009. Hepatology. 2010;51(1):306.

    Article  PubMed  Google Scholar 

  27. Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology (Baltimore, MD). 2000;31(4):864–71.

    Article  CAS  Google Scholar 

  28. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology (Baltimore, MD). 2001;33(2):464–70.

    Article  CAS  Google Scholar 

  29. Singal AK, Kamath PS. Model for end-stage liver disease. J Clin Exp Hepatol. 2013;3(1):50–60.

    Article  PubMed  Google Scholar 

  30. Ferral H. The evaluation of the patient undergoing an elective transjugular intrahepatic portosystemic shunt procedure. Semin Interv Radiol. 2005;22(4):266–70.

    Article  Google Scholar 

  31. Ferral H, Gamboa P, Postoak DW, Albernaz VS, Young CR, Speeg KV, et al. Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score. Radiology. 2004;231(1):231–6.

    Article  PubMed  Google Scholar 

  32. Montgomery A, Ferral H, Vasan R, Postoak DW. MELD score as a predictor of early death in patients undergoing elective transjugular intrahepatic portosystemic shunt (TIPS) procedures. Cardiovasc Intervent Radiol. 2005;28(3):307–12.

    Article  PubMed  Google Scholar 

  33. Fidelman N, Kwan SW, LaBerge JM, Gordon RL, Ring EJ, Kerlan RK. The Transjugular intrahepatic portosystemic shunt: an update. Am J Roentgenol. 2012;199(4):746–55.

    Article  Google Scholar 

  34. Bai M, Qi X, Yang Z, Yin Z, Nie Y, Yuan S, et al. Predictors of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in cirrhotic patients: a systematic review. J Gastroenterol Hepatol. 2011;26(6):943–51.

    Article  PubMed  Google Scholar 

  35. Sanyal AJ, Genning C, Reddy KR, Wong F, Kowdley KV, Benner K, et al. The North American study for the treatment of refractory ascites. Gastroenterology. 2003;124(3):634–41.

    Article  PubMed  Google Scholar 

  36. Garcia-Pagán JC, Heydtmann M, Raffa S, Plessier A, Murad S, Fabris F, et al. TIPS for Budd-Chiari syndrome: long-term results and prognostics factors in 124 patients. Gastroenterology. 2008;135(3):808–15.

    Article  PubMed  Google Scholar 

  37. Rössle M, Olschewski M, Siegerstetter V, Berger E, Kurz K, Grandt D. The Budd-Chiari syndrome: outcome after treatment with the transjugular intrahepatic portosystemic shunt. Surgery. 2004;135(4):394–403.

    Article  PubMed  Google Scholar 

  38. Dariushnia SR, Haskal ZJ, Midia M, Martin LG, Walker TG, Kalva SP, et al. Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol. 2016;27(1):1–7.

    Article  PubMed  Google Scholar 

  39. Madoff DC, Wallace MJ, Ahrar K, Saxon RR. TIPS-related hepatic encephalopathy: management options with novel endovascular techniques. Radiogr Rev Publ Radiol Soc N Am Inc. 2004;24(1):21–36–37.

    Google Scholar 

  40. Madoff DC, Wallace MJ. Reduced stents and stent-grafts for the management of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt creation. Semin Interv Radiol. 2005;22(4):316–28.

    Article  Google Scholar 

  41. Ferenci P. Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of gastroenterology, Vienna, 1998. Hepatology. 2002;35(3):716–21.

    Article  PubMed  Google Scholar 

  42. Weber CN, Nadolski GJ, White SB, Clark TWI, Mondschein JI, Stavropoulos SW, et al. Long-Term Patency and Clinical Analysis of Expanded Polytetrafluoroethylene-Covered Transjugular Intrahepatic Portosystemic Shunt Stent Grafts. J Vasc Interv Radiol JVIR. 2015;26(9):1257–1265; quiz 1265.

    Article  PubMed  Google Scholar 

  43. Suhocki P, Lungren M, Kapoor B, Kim C. Transjugular intrahepatic portosystemic shunt complications: prevention and management. Semin Interv Radiol. 2015;32(2):123–32.

    Article  Google Scholar 

  44. Luca A, Miraglia R, Maruzzelli L, D’Amico M, Tuzzolino F. Early liver failure after transjugular intrahepatic portosystemic shunt in patients with cirrhosis with model for end-stage liver disease score of 12 or less: incidence, outcome, and prognostic factors. Radiology. 2016;280(2):622–9.

    Article  PubMed  Google Scholar 

  45. Chung H-H, Razavi MK, Sze DY, Frisoli JK, Kee ST, Dake MD, et al. Portosystemic pressure gradient during transjugular intrahepatic portosystemic shunt with Viatorr stent graft: what is the critical low threshold to avoid medically uncontrolled low pressure gradient related complications? J Gastroenterol Hepatol. 2008;23(1):95–101.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ziv J Haskal .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Koppula, R., Haskal, Z.J. (2018). Transjugular Intrahepatic Portosystemic Shunt (TIPS) and Portal Hypertension. In: Keefe, N., Haskal, Z., Park, A., Angle, J. (eds) IR Playbook. Springer, Cham. https://doi.org/10.1007/978-3-319-71300-7_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-71300-7_38

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-71299-4

  • Online ISBN: 978-3-319-71300-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics