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Platinum in Biomedical Applications

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Biomedical Applications of Metals

Abstract

For a long time, platinum (Pt) is used in medicine because of its outstanding properties such as biocompatibility, electrical conductivity, radiopacity, and durability. Despite the high cost of the noble metal, its unique properties were exploited in a large number of medical devices. These include stents, catheters, pacemakers, defibrillators, cochlear implants, and many others. Pt compounds play an important role in cancer therapy. In the age of nanotechnology, the horizon of the potential applications of Pt was substantially expanded. Nanostructured Pt-based materials were proposed for producing electrodes with advanced characteristics embedded in implantable electronic devices and sensors for detection of biologically important molecules. Pt nanoparticles (PtNPs) are perspective for the treatment of the diseases related to oxidative stress. It is expected that nanoparticle formulations will reduce adverse effects of Pt-based anticancer drugs. In this chapter, we review the traditional and new fields of Pt application in medicine. Special attention is paid to the questions of in vivo biocompatibility and corrosion behavior of Pt implants. In conclusion, we summarize the benefits of Pt usage for future medicine and diagnostics and indicate the problems to be solved to give the green light for the Pt-based new products to get entry in medical market.

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Authors and Affiliations

  1. Laboratory for Physical Chemistry of Polymers, A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova St. 28, 119991, Moscow, Russia

    Olga Sinitsyna

  2. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    Olga Sinitsyna

  3. Nanobiotechnology Lab, Department of Biotechnology, SGB Amravati University, Amravati, 444602, Maharashtra, India

    Priti Paralikar, Raksha Pandit & Mahendra Rai

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  1. Olga Sinitsyna
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  2. Priti Paralikar
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  3. Raksha Pandit
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  4. Mahendra Rai
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Correspondence to Olga Sinitsyna .

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Editors and Affiliations

  1. Nanobiotechnology Laboratory, Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Nanobiotechnology Laboratory, Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India

    Avinash P. Ingle

  3. Departmento Di Chimica Farmacia, University of Sassari, Sassari, Italy

    Serenella Medici

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Sinitsyna, O., Paralikar, P., Pandit, R., Rai, M. (2018). Platinum in Biomedical Applications. In: Rai, M., Ingle, A., Medici, S. (eds) Biomedical Applications of Metals. Springer, Cham. https://doi.org/10.1007/978-3-319-74814-6_7

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