Abstract
Acute rheumatic fever remains one of the major autoimmune disorders known to occur as a result of a specific pathogen, group A Streptococcus (Streptococcus pyogenes), even though the precise mechanism is incompletely understood. Post-streptococcal reactive arthritis and post-streptococcal glomerulonephritis similarly follow group A streptococcal infections. Group A streptococcus-induced autoimmunity via suspected molecular mimicry has ramifications for future microbiome research and management and prevention of rheumatologic diseases.
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Abbreviations
- ARF:
-
Acute rheumatic fever
- GAS:
-
Group A streptococcus
- MHC:
-
Major histocompatibility complex
- PSGN:
-
Post-streptococcal glomerulonephritis
- PSRA:
-
Post-streptococcal reactive arthritis
- RHD:
-
Rheumatic heart disease
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Erdem, G., Kaplan, E.L. (2018). Rheumatic Complications of Streptococcus pyogenes . In: Ragab, G., Atkinson, T., Stoll, M. (eds) The Microbiome in Rheumatic Diseases and Infection. Springer, Cham. https://doi.org/10.1007/978-3-319-79026-8_9
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DOI: https://doi.org/10.1007/978-3-319-79026-8_9
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