Abstract
A 34-year-old woman with Philadelphia chromosome-positive pre-B-cell acute lymphocytic leukemia who received a matched-related-donor myeloablative hematopoietic stem cell transplant (HSCT) 3 days ago is admitted to the hospital with worsening abdominal exam and a new fever (temperature 39.5 °C). The patient is diagnosed with gram-negative typhlitis (neutropenic enterocolitis) and started on antibiotic therapy; however, the patient’s condition does not improve. Alternate-day granulocyte transfusions over 10–14 days are requested by the patient’s hematologist to help treat the bacterial infection in the setting of profound neutropenia (white blood cells [WBCs] less than 1.0 K/μL) until HSCT engraftment occurs. An ethylenediaminetetraacetic acid (EDTA) anticoagulant sample is submitted to the blood bank for type and screen.
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Reference
Hölig K. G-CSF in healthy allogeneic stem cell donors. Transfusion Med Hemother. 2013;40(4):225–35.
Recommended Reading
Nester T, Jain S, Poisson J. Hemotherapy decisions and their outcomes. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, editors. Technical manual. 18th ed. Bethesda: AABB; 2014. p. 523–6.
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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Jhang, J.S. (2018). Golden Grans. In: Immunohematology and Transfusion Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-90960-8_38
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DOI: https://doi.org/10.1007/978-3-319-90960-8_38
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