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Helicobacter Pylori

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Gastrointestinal Physiology

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Abstract

Helicobacter pylori (H. pylori) is a gastro-infective agent that colonizes the stomach of nearly half of humans in the world. The infective nature of this agent is due to its ability to change the physiology of the immediate gastric environment. Several factors are responsible for determining the ability of H. pylori to cause infection. This chapter deals with the pathophysiology of H. pylori.

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Abbreviations

Cag:

Cytotoxin-associated gene

CagA:

Cytotoxin-associated antigen

GI:

Gastrointestinal

H. pylori :

Helicobacter pylori

MALT:

Mucosa-associated lymphoid tissue

NOD:

Nucleotide-binding oligomerization domain

Bibliography

  1. Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273–1275

    PubMed  CAS  Google Scholar 

  2. Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1(8390):1311–1315

    Article  PubMed  CAS  Google Scholar 

  3. Konturek SJ, Konturek PC, Konturek JW, Plonka M, Czesnikiewicz-Guzik M, Brzozowski T, Bielanski W (2006) Helicobacter pylori and its involvement in gastritis and peptic ulcer formation. J Physiol Pharmacol 57(3):29–50

    PubMed  Google Scholar 

  4. Garza-González E, Perez-Perez GI, Maldonado-Garza HJ, Bosques-Padilla FJ (2014) A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication. World J Gastroenterol 20(6):1438–1449

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Franceschi F, Tortora A, Gasbarrini G, Gasbarrini A (2014) Helicobacter pylori and extragastric diseases. Helicobacter 19(1):52–58

    Article  PubMed  CAS  Google Scholar 

  6. Campuzano-Maya G (2011) Cure of alopecia areata after eradication of Helicobacter pylori: a new association? World J Gastroenterol 17(26):3165–3170

    PubMed  PubMed Central  Google Scholar 

  7. Hershko C, Ianculovich M, Souroujon M (2007) A hematologist’s view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication. Blood Cells Mol Dis 38(1):45–53

    Article  PubMed  CAS  Google Scholar 

  8. Kabeer KK, Ananthakrishnan N, Anand C, Balasundaram S (2017) Prevalence of Helicobacter Pylori infection and stress, anxiety or depression in functional dyspepsia and outcome after appropriate intervention. J Clin Diagn Res 11(8):VC11–VC15

    Google Scholar 

  9. Guarneri C, Lotti J, Fioranelli M, Roccia MG, Lotti T, Guarneri F (2017) Possible role of Helicobacter pylori in diseases of dermatological interest. J Biol Regul Homeost Agents 31(2 Suppl 2):57–77

    PubMed  CAS  Google Scholar 

  10. Goni E, Franceschi F (2016) Helicobacter pylori and extragastric diseases. Helicobacter 21(1):45–48

    Article  PubMed  Google Scholar 

  11. Testerman TL, Morris J (2014) Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. World J Gastroenterol 20(36):12781–12808

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Uotani T, Graham DY (2015) Diagnosis of Helicobacter pylori using the rapid urease test. Ann Transl Med 3(1):9

    PubMed  PubMed Central  Google Scholar 

  13. Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE et al (2011) Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog 7(9):e1002237

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Nocon M, Kuhlmann A, Leodolter A, Roll S, Vauth C, Willich SN, Greiner W (2009) Efficacy and cost-effectiveness of the 13C-urea breath test as the primary diagnostic investigation for the detection of Helicobacter pylori infection compared to invasive and non-invasive diagnostic tests. GMS Health Technol Assess 5:Doc14

    Google Scholar 

  15. Konstantopoulos N, Rüssmann H, Tasch C, Sauerwald T, Demmelmair H, Autenrieth I, Koletzko S (2001) Evaluation of the Helicobacter pylori stool antigen test (HpSA) for detection of Helicobacter pylori infection in children. Am J Gastroenterol 96(3):677–683

    Article  PubMed  CAS  Google Scholar 

  16. Kim SS, Ruiz VE, Carroll JD, Moss SF (2011) Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma. Cancer Lett 305(2):228–238

    Article  PubMed  CAS  Google Scholar 

  17. Tseng T-T, Tyler BM, Setubal JC (2009) Protein secretion systems in bacterial-host associations, and their description in the gene ontology. BMC Microbiol 9(1):S2

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Jiménez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R (2013) Dynamics of the cag-type IV secretion system of Helicobacter pylori as studied by bacterial co-infections. Cell Microbiol 15(11):1924–1937

    PubMed  Google Scholar 

  19. Krishnamurthy P, Parlow M, Zitzer JB, Vakil NB, Mobley HL, Levy M et al (1998) Helicobacter pylori containing only cytoplasmic urease is susceptible to acid. Infect Immun 66(11):5060–5066

    PubMed  PubMed Central  CAS  Google Scholar 

  20. Sachs G, Scott DR, Weeks DL, Rektorscheck M, Melchers K (2001) Regulation of urease for acid habitation. In: Mobley HLT, Mendz GL, Hazell SL (eds) Helicobacter pylori: physiology and genetics. ASM Press, Washington, DC, USA

    Google Scholar 

  21. Mobley HL (1996) The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration. Aliment Pharmacol Ther 10(1):57–64

    Article  PubMed  CAS  Google Scholar 

  22. Sidebotham RL, Worku ML, Karim QN, Dhir NK, Baron JH (2003) How Helicobacter pylori urease may affect external pH and influence growth and motility in the mucus environment: evidence from in-vitro studies. Eur J Gastroenterol Hepatol 15(4):395–401

    Article  PubMed  CAS  Google Scholar 

  23. Weeks DL, Eskandari S, Scott DR, Sachs G (2000) A H + -gated urea channel: the link between Helicobacter pylori urease and gastric colonization. Science 287(5452):482–485

    Article  PubMed  CAS  Google Scholar 

  24. Mobley HL, Hu LT, Foxal PA (1991) Helicobacter pylori urease: properties and role in pathogenesis. Scand J Gastroenterol Suppl 187:39–46

    Article  PubMed  CAS  Google Scholar 

  25. Sjöström JE, Larsson H (1996) Factors affecting growth and antibiotic susceptibility of Helicobacter pylori: effect of pH and urea on the survival of a wild-type strain and a urease-deficient mutant. J Med Microbiol 44(6):425–433

    Article  PubMed  Google Scholar 

  26. Croxen MA, Sisson G, Melano R, Hoffman PS (2006) The Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosa. J Bacteriol 188(7):2656–2665

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Huang JY, Goers Sweeney E, Guillemin K, Amieva MR (2017) Multiple acid sensors control Helicobacter pylori colonization of the stomach. PLoS Pathog 13(1):e1006118

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  28. Machuca MA, Johnson KS, Liu YC, Steer DL, Ottemann KM, Roujeinikova A (2017) Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate. Sci Rep 7(1):14089

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Williams SM, Chen YT, Andermann TM, Carter JE, McGee DJ, Ottemann KM (2007) Helicobacter pylori chemotaxis modulates inflammation and bacterium-gastric epithelium interactions in infected mice. Infect Immun 75(8):3747–3757

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. Aihara E, Closson C, Matthis AL, Schumacher MA, Engevik AC, Zavros Y et al (2014) Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori. PLoS Pathog 10(7):e1004275

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  31. Behrens W, Schweinitzer T, McMurry JL, Loewen PC, Buettner FFR, Menz S, Josenhans C (2016) Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions. Sci Rep 6:23582

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Rugge M, Pennelli G, Pilozzi E, Fassan M, Ingravallo G, Russo VM et al (2011) Gastritis: the histology report. Dig Liver Dis 43(4):S373–S384

    Article  PubMed  Google Scholar 

  33. Kuipers EJ (1998) Relationship between Helicobacter pylori, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 12(1):25–36

    Article  PubMed  Google Scholar 

  34. Rugge M, Correa P, Di Mario F, El-Omar E, Fiocca R, Geboes K et al (2008) OLGA staging for gastritis: a tutorial. Dig Liver Dis 40(8):650–658

    Article  PubMed  CAS  Google Scholar 

  35. Sugimoto M, Ban H, Ichikawa H, Sahara S, Otsuka T, Inatomi O et al (2017) Efficacy of the Kyoto classification of gastritis in identifying patients at high risk for gastric cancer. Intern Med 56(6):579–586

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rugge M, Meggio A, Pennelli G, Piscioli F, Giacomelli L, De Pretis G, Graham DY (2007) Gastritis staging in clinical practice: the OLGA staging system. Gut 56(5):631–636

    Article  PubMed  Google Scholar 

  37. Quiding-Järbrink M, Ahlstedt I, Lindholm C, Johansson E-L, Lönroth H (2001) Homing commitment of lymphocytes activated in the human gastric and intestinal mucosa. Gut 49:519–525

    Article  PubMed  PubMed Central  Google Scholar 

  38. Vorobjova T, Ren Z, Dunkley M, Clancy R, Maaroos HI, Labotkin R et al (2006) Response of IgG1 and IgG2 subclasses to Helicobacter pylori in subjects with chronic inflammation of the gastric mucosa, atrophy and gastric cancer in a country with high Helicobacter pylori infection prevalence. APMIS 114(5):372–380

    Article  PubMed  CAS  Google Scholar 

  39. Khalifehgholi M, Shamsipour F, Ajhdarkosh H, Ebrahimi Daryani N, Pourmand MR, Hosseini M et al (2013) Comparison of five diagnostic methods for Helicobacter pylori. Iran J Microbiol 5(4):396–401

    PubMed  PubMed Central  Google Scholar 

  40. Pajares-García JM (1998) Diagnosis of Helicobacter pylori: invasive methods. Ital J Gastroenterol Hepatol 30(3):S320–S323

    PubMed  Google Scholar 

  41. Burette A (1998) How (who?) and when to test or retest for H. pylori. Acta Gastroenterol Belg 61(3):336–343

    PubMed  CAS  Google Scholar 

  42. Kim CG, Choi IJ, Lee JY, Cho SJ, Nam BH, Kook MC et al (2009) Biopsy site for detecting Helicobacter pylori infection in patients with gastric cancer. J Gastroenterol Hepatol 24(3):469–474

    Article  PubMed  Google Scholar 

  43. Wong A, Ching SS, Long AS (2014) The use of a second biopsy from the gastric body for the detection of Helicobacter pylori using rapid urease test. Singapore Med J 55(12):644–647

    Article  PubMed  PubMed Central  Google Scholar 

  44. Bermejo F, Boixeda D, Gisbert JP, Defarges V, Sanz JM, Redondo C et al (2002) Rapid urease test utility for Helicobacter pylori infection diagnosis in gastric ulcer disease. Hepatogastroenterology 49(44):572–575

    PubMed  Google Scholar 

  45. Arslan N, Yılmaz Ö, Demiray-Gürbüz E (2017) Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection. World J Gastroenterol 23(16):2854–2869

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  46. Zamani M, Rahbar A, Shokri-Shirvani J (2017) Resistance of Helicobacter pylori to furazolidone and levofloxacin: a viewpoint. World J Gastroenterol 23(37):6920–6922

    Article  PubMed  PubMed Central  Google Scholar 

  47. Chen YL, Mo XQ, Huang GR, Huang YQ, Xiao J, Zhao LJ et al (2016) Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases. World J Gastroenterol 22(44):9718–9726

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  48. Ho GY, Windsor HM (2000) Accurate diagnosis of Helicobacter pylori: polymerase chain reaction tests. Gastroenterol Clin North Am 29(4):903–915

    Article  PubMed  CAS  Google Scholar 

  49. Bakhtiari S, Alvandi A, Pajavand H, Navabi J, Najafi F, Abiri R (2016) Development and diagnostic evaluation of loop-mediated isothermal amplification using a new gene target for rapid detection of Helicobacter pylori. Jundishapur J Microbiol 9(5):e28831

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  50. Yari F, Abiri R, Aryan E, Ahmadi Jouybari T, Navabi J, Alvandi A (2016) Loop-mediated isothermal amplification as a fast noninvasive method of Helicobacter pylori diagnosis. J Clin Lab Anal 30(5):464–470

    Article  PubMed  CAS  Google Scholar 

  51. Zhou Q, Li L, Ai Y, Pan Z, Guo M, Han J (2017) Diagnostic accuracy of the 14C-urea breath test in Helicobacter pylori infections: a meta-analysis. Wien Klin Wochenschr 129(1–2):38–45

    Article  PubMed  CAS  Google Scholar 

  52. Ling D (2013) Carbon-13 urea breath test for Helicobacter pylori infection in patients with uninvestigated ulcer-like dyspepsia: an evidence-based analysis. Ont Health Technol Assess Ser 13(19):1–30

    PubMed  PubMed Central  CAS  Google Scholar 

  53. Goddard AF, Logan RPH (1997) Urea breath tests for detecting Helicobacter pylori. Aliment Pharmacol Ther 11:641–649

    Article  PubMed  CAS  Google Scholar 

  54. Manes G, Zanetti MV, Piccirillo MM, Lombardi G, Balzano A, Pieramico O (2005) Accuracy of a new monoclonal stool antigen test in post-eradication assessment of Helicobacter pylori infection: comparison with the polyclonal stool antigen test and urea breath test. Dig Liver Dis 37(10):751–755

    Article  PubMed  CAS  Google Scholar 

  55. Paimela HM, Oksala NK, Kääriäinen IP, Carlson PJ, Kostiala AA, Sipponen PI (2006) Faecal antigen tests in the confirmation of the effect of Helicobacter eradication therapy. Ann Med 38(5):352–356

    Article  PubMed  Google Scholar 

  56. Shady MMA, Fathy HA, Ali A, Galal EM, Fathy GA, Sibaii H (2015) Comparison of serum IgG antibody test with gastric biopsy for the detection of Helicobacter pylori infection among Egyptian children. Open Access Maced J Med Sci 3(2):303–306

    Article  PubMed  PubMed Central  Google Scholar 

  57. Pandya HB, Patel JS, Agravat HH, Singh NKR (2014) Non-invasive diagnosis of Helicobacter pylori: evaluation of two enzyme immunoassays, testing serum IgG and IgA response in the Anand district of Central Gujarat, India. J Clin Diagn Res 8(6):DC12–DC15

    Google Scholar 

  58. Shuto M, Fujioka T, Matsunari O, Okamoto K, Mizukami K, Okimoto T et al (2017) Association between gastric cancer risk and serum Helicobacter pylori antibody titers. Gastroenterol Res Pract 2017:1286198

    Article  PubMed  PubMed Central  Google Scholar 

  59. She RC, Wilson AR, Litwin CM (2009) Evaluation of Helicobacter pylori immunoglobulin G (IgG), IgA, and IgM serologic testing compared to stool antigen testing. Clin Vaccine Immunol 16(8):1253–1255

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  60. Li S, Lu AP, Zhang L, Li YD (2003) Anti-Helicobacter pylori immunoglobulin G (IgG) and IgA antibody responses and the value of clinical presentations in diagnosis of H. pylori infection in patients with precancerous lesions. World J Gastroenterol 9(4):755–758

    Article  PubMed  PubMed Central  Google Scholar 

  61. Okuda M, Mabe K, Lin Y, Chaochen W, Taniguchi Y, Kato M, Kikuchi S (2017) Rapid urine antibody test for Helicobacter pylori infection in adolescents. Pediatr Int 59(7):798–802

    Article  PubMed  CAS  Google Scholar 

  62. Mabe K, Kikuchi S, Okuda M, Takamasa M, Kato M, Asaka M (2017) Diagnostic accuracy of urine Helicobacter pylori antibody test in junior and senior high school students in Japan. Helicobacter 22(1):e12329

    Article  CAS  Google Scholar 

  63. Desai JC, Goo T, Fukata M, Sanyal S, Dikman A, Miller K et al (2009) NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression. Aliment Pharmacol Ther 30(1):71–81

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  64. Shephard RJ (2017) Peptic ulcer and exercise. Sports Med 47(1):33–40

    Article  PubMed  Google Scholar 

  65. Yeomans NDNJ (2008) Systematic review: ulcer definition in NSAID ulcer prevention trials. Aliment Pharmacol Ther 15(27):465–472

    Article  Google Scholar 

  66. Henke CJ, Levin TR, Henning JM, Potter LP (2000) Work loss costs due to peptic ulcer disease and gastroesophageal reflux disease in a health maintenance organization. Am J Gastroenterol 95(3):788–792

    Article  PubMed  CAS  Google Scholar 

  67. Joish VN, Donaldson G, Stockdale W, Oderda GM, Crawley J, Sasane R et al (2005) The economic impact of GERD and PUD: examination of direct and indirect costs using a large integrated employer claims database. Curr Med Res Opin 21(4):535–544

    Article  PubMed  Google Scholar 

  68. Wen Z, Li X, Lu Q, Brunson J, Zhao M, Tan J et al (2014) Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. BMC Gastroenterol 14:149

    Article  PubMed  PubMed Central  Google Scholar 

  69. Ramakrishnan K, Salinas RC (2007) Peptic ulcer disease. Am Fam Physician 76(7):1005–1012

    PubMed  Google Scholar 

  70. Quan C, Talley NJ (2002) Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs. Am J Gastroenterol 97(12):2950–2961

    Article  PubMed  Google Scholar 

  71. Ford AC, Gurusamy KS, Delaney B, Forman D, Moayyedi P (2016) Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people. Cochrane Database Syst Rev 4:CD003840

    Google Scholar 

  72. Yuan Y, Padol IT, Hunt RH (2006) Peptic ulcer disease today. Nat Clin Pract Gastroenterol Hepatol 3(2):80–89

    Article  PubMed  CAS  Google Scholar 

  73. Chung C-S, Chiang T-H, Lee Y-C (2015) A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med 30(5):559–570

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  74. Kim HU (2015) Diagnostic and treatment approaches for refractory peptic ulcers. Clin Endosc 48(4):285–290

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Rosenstock S, Jørgensen T, Bonnevie O, Andersen L (2003) Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 danish adults. Gut 52(2):186–193

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  76. Najm WI (2011) Peptic ulcer disease. Prim Care Clin Office Pract 38(3):383–394

    Article  Google Scholar 

  77. Kang JM, Kim N, Lee BH, Park HK, Jo HJ, Shin CM et al (2011) Risk factors for peptic ulcer bleeding in terms of Helicobacter pylori, NSAIDs, and antiplatelet agents. Scand J Gastroenterol 46(11):1295–1301

    Article  PubMed  CAS  Google Scholar 

  78. Mhaskar RS, Ricardo I, Azliyati A, Laxminarayan R, Amol B, Santosh W, Boo K (2013) Assessment of risk factors of Helicobacter pylori infection and peptic ulcer disease. J Glob Infect Dis 5(2):60–67

    Article  PubMed  PubMed Central  Google Scholar 

  79. Levenstein S, Rosenstock S, Jacobsen RK, Jorgensen T (2015) Psychological stress increases risk for peptic ulcer, regardless of Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs. Clin Gastroenterol Hepatol 13(3):498–506

    Article  PubMed  Google Scholar 

  80. Boylan MR, Khalili H, Huang ES, Chan AT (2014) Measures of adiposity are associated with increased risk of peptic ulcer. Clin Gastroenterol Hepatol 12(10):1688–1694

    Article  PubMed  PubMed Central  Google Scholar 

  81. Abadi AT, Kusters JG (2016) Management of Helicobacter pylori infections. BMC Gastroenterol 16(1):94

    Article  PubMed  PubMed Central  Google Scholar 

  82. Slomiany BL, Murty VL, Piotrowski J, Slomiany A (1994) Gastroprotective agents in mucosal defense against Helicobacter pylori. Gen Pharmacol 25(5):833–841

    Article  PubMed  CAS  Google Scholar 

  83. Slomiany BL, Slomiany A (1992) Mechanism of Helicobacter pylori pathogenesis: focus on mucus. J Clin Gastroenterol 14(1):S114–S121

    Article  PubMed  Google Scholar 

  84. Caruso R, Warner N, Inohara N, Núñez G (2014) NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41(6):898–908

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Watanabe T, Asano N, Kudo M, Strober W (2017) Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders. Proc Jpn Acad Ser B Phys Biol Sci 93(8):578–599

    Article  PubMed  PubMed Central  Google Scholar 

  86. Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22(2):240–273

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  87. Patel MK, Trombly MI, Kurt-Jones EA (2012) Innate immune responses to Helicobacter pylori infection: an overview. In: Houghton J (ed) Helicobacter species. Methods in molecular biology (methods and protocols), vol 921. Humana Press, Totowa, New Jersey, United States

    Chapter  Google Scholar 

  88. Kim HS, Kim J, Im HN, An DR, Lee M, Hesek D et al (2014) Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a d, l-carboxypeptidase controlling the helical cell shape. Acta Crystallogr D Biol Crystallogr 70(Pt 11):2800–2812

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  89. Barnich N, Aguirre JE, Reinecker H-C, Xavier R, Podolsky DK (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition. J Cell Biol 170(1):21–26

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  90. Semper RP, Mejías-Luque R, Groß C, Anderl F, Müller A, Vieth M et al (2014) Helicobacter pylori-induced IL-1β secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. J Immunol 193(7):3566–3576

    Article  PubMed  CAS  Google Scholar 

  91. Newton JL, Jordan N, Oliver L, Strugala V, Pearson J, James OF, Allen A (1998) Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised. Gut 43(4):470–475

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Allen A, Newton J, Oliver L, Jordan N, Strugala V, Pearson JP, Dettmar PW (1997) Mucus and H. pylori. J Physiol Pharmacol 48(3):297–305

    PubMed  CAS  Google Scholar 

  93. Lee SP, Sung IK, Kim JH, Lee SY, Park HS, Shim CS (2017) Risk factors for the presence of symptoms in peptic ulcer disease. Clin Endosc 50(6):578–584

    Article  PubMed  Google Scholar 

  94. Khademi H, Radmard A-R, Malekzadeh F, Kamangar F, Nasseri-Moghaddam S, Johansson M et al (2012) Diagnostic accuracy of age and alarm symptoms for upper GI malignancy in patients with dyspepsia in a GI clinic: a 7-year cross-sectional study. PLoS ONE 7(6):e39173

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  95. Fashner J, Gitu AC (2015) Diagnosis and treatment of peptic ulcer disease and H. pylori infection. Am Fam Physician 91(4):236–242

    PubMed  Google Scholar 

  96. Hunt RH (1997) Peptic ulcer disease: defining the treatment strategies in the era of Helicobacter pylori. Am J Gastroenterol 92(4):36S–43S

    PubMed  CAS  Google Scholar 

  97. Ji Y, Lu H (2018) Meta-analysis: high-dose vs. low-dose metronidazole-containing therapies for Helicobacter pylori eradication treatment. PLoS ONE 13(1):e0189888

    Article  PubMed  PubMed Central  Google Scholar 

  98. Safavi M, Sabourian R, Foroumadi A (2016) Treatment of Helicobacter pylori infection: current and future insights. World J Clin Cases 4(1):5–19

    Article  PubMed  PubMed Central  Google Scholar 

  99. Almeida N, Donato MM, Romãozinho JM, Luxo C, Cardoso O, Cipriano MA et al (2015) Beyond maastricht IV: are standard empiric triple therapies for Helicobacter pylori still useful in a South-European country? BMC Gastroenterol 15:23

    Article  PubMed  PubMed Central  Google Scholar 

  100. Davis S (2014) Eradication of Helicobacter pylori. S Afr Fam Pract 56(3):1–4

    Google Scholar 

  101. Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, Zhou R et al (2017) Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol 73(10):1199–1208

    Article  PubMed  Google Scholar 

  102. Lau CS, Ward A, Chamberlain RS (2016) Probiotics improve the efficacy of standard triple therapy in the eradication of Helicobacter pylori: a meta-analysis. Infect Drug Resist 9:275–289

    Article  PubMed  PubMed Central  Google Scholar 

  103. Wen J, Peng P, Chen P, Zeng L, Pan Q, Wei W, He J (2017) Probiotics in 14-day triple therapy for Asian pediatric patients with Helicobacter pylori infection: a network meta-analysis. Oncotarget 8(56):96409–96418

    PubMed  PubMed Central  Google Scholar 

  104. Milosavljevic T, Kostić-Milosavljević M, Jovanović Krstić M (2011) Complications of peptic ulcer disease. Dig Dis 29(5):491–493

    Article  PubMed  Google Scholar 

  105. Tonolini M, Ierardi AM, Bracchi E, Magistrelli P, Vella A, Carrafiello G (2017) Non-perforated peptic ulcer disease: multidetector CT findings, complications, and differential diagnosis. Insights Imaging 8(5):455–469

    Article  PubMed  PubMed Central  Google Scholar 

  106. International Agency for Research on Cancer (IARC) (1994) Evaluation of carcinogenic risks to humans. Lyon, Frnace

    Google Scholar 

  107. Sipponen P, Hyvärinen H (1993) Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer. Scand J Gastroenterol Suppl 196:3–6

    Article  PubMed  CAS  Google Scholar 

  108. Dixon MF (1994) Pathophysiology of Helicobacter pylori infection. Scand J Gastroenterol Suppl 201:7–10

    Article  PubMed  CAS  Google Scholar 

  109. Kuipers EJ (1999) Exploring the link between Helicobacter pylori and gastric cancer. Aliment Pharmacol Ther 13(1):3–11

    Article  PubMed  Google Scholar 

  110. Saber T, Ghonaim MM, Yousef AR, Khalifa A, Al Qurashi H, Shaqhan M, Samaha M (2015) Association of Helicobacter pylori cagA gene with gastric cancer and peptic ulcer in saudi patients. J Microbiol Biotechnol 25(7):1146–1153

    Article  PubMed  CAS  Google Scholar 

  111. Hatakeyama M (2006) The role of Helicobacter pylori CagA in gastric carcinogenesis. Int J Hematol 84(4):301–308

    Article  PubMed  CAS  Google Scholar 

  112. Hatakeyama M (2014) Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis. Cell Host Microbe 15(3):306–316

    Article  PubMed  CAS  Google Scholar 

  113. Graham DY, Yamaoka Y (1998) H. pylori and cagA: relationships with gastric cancer, duodenal ulcer, and reflux esophagitis and its complications. Helicobacter 3(3):145–151

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Nile University of Nigeria, FCT-Abuja, Nigeria

    Menizibeya Osain Welcome MD, PhD

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  1. Menizibeya Osain Welcome MD, PhD
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Correspondence to Menizibeya Osain Welcome MD, PhD .

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Welcome, M.O. (2018). Helicobacter Pylori. In: Gastrointestinal Physiology. Springer, Cham. https://doi.org/10.1007/978-3-319-91056-7_14

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