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Evaluation of Functional Hyperemia Using NIRTRS Without the Influence of Fat Layer Thickness

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Oxygen Transport to Tissue XL

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1072))

Abstract

Fat layer thickness (FLT) affects near infrared spectroscopy (NIRS) measurement. The aim of this study was to determine an indicator of muscle function with less influence of FLT, even without normalization, by comparing muscle O2 dynamics during exercise in subjects with similar physical characteristics except for FLT. Healthy male subjects with thick FLT (n = 5, FLT: 5.3 ± 0.4 mm) and those with thin FLT (n = 6, FLT: 3.5 ± 0.5 mm) participated in this study. All subjects performed constant work cycling exercise (CWE) at moderate intensity for 6 min. Oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration and total hemoglobin concentration were monitored by using time resolved NIRS (NIRTRS). VO2peak was not significantly different between THICK and THIN (THICK: 54.0 ± 1.8, THIN: 50.0 ± 6.2 mL/kg/min). Changes in all NIRTRS variables at the onset of CWE were significantly larger in THIN than THICK, and the changes in each variable were significantly correlated to FLT. In contrast, there were no relationships between changes in NIRTRS variables during CWE and FLT. These results suggest that muscle deoxygenation at the onset of exercise, which is used as muscle O2 extraction, can be strongly influenced by FLT. In contrast, muscle oxygenation during CWE, which is used as exercise-induced functional hyperemia , may not be influenced by FLT.

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Acknowledgments

The authors are grateful to Andrea Hope for revision of this manuscript. We also thank Mikiko Anjo and Ayaka Kime (Tokyo Medical University, Japan) for their helpful technical assistance. This study was supported by JSPS KAKENHI Grant Number 16K01735.

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Authors and Affiliations

  1. Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan

    Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Tsubasa Watanabe, Norio Murase, Yuko Kurosawa & Takafumi Hamaoka

  2. Department of Internal Medicine, Kosei Chuo General Hospital, Tokyo, Japan

    Tsubasa Watanabe

  3. Department of Internal Medicine, Kuretake Medical Clinic, Saitama, Japan

    Norio Murase

Authors
  1. Tasuki Endo
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  2. Ryotaro Kime
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  3. Sayuri Fuse
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  4. Tsubasa Watanabe
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  5. Norio Murase
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  6. Yuko Kurosawa
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  7. Takafumi Hamaoka
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Corresponding author

Correspondence to Tasuki Endo .

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Editors and Affiliations

  1. Julius Bernstein Institute of Physiology, Martin Luther University, Halle-Wittenberg, Halle/Saale, Germany

    Oliver Thews

  2. Department of Physiology & Biophysics, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

    Joseph C. LaManna

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

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Endo, T. et al. (2018). Evaluation of Functional Hyperemia Using NIRTRS Without the Influence of Fat Layer Thickness. In: Thews, O., LaManna, J., Harrison, D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, vol 1072. Springer, Cham. https://doi.org/10.1007/978-3-319-91287-5_16

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