Skip to main content
SpringerLink
Log in

Drug-Coated Balloons in Native Coronary Artery Disease

  • Chapter
  • First Online:
Drug-Coated Balloons

  • 505 Accesses

Abstract

The advent of drug-eluting stent (DES) technology for the treatmentofcoronary artery disease (CAD) has significantly reduced the problem of in-stent restenosis caused by neointimal hyperplasia. Some of the limitations of DES include treatment of small vessel disease, issues related to the duration of dual antiplatelet therapy (DAPT), and treatment failure leading to restenosis and late or very late stent thrombosis, especially in complex lesions subsets such as bifurcation lesions. In this light, drug-coated balloons (DCBs) represent an innovation with a high potential impact on the treatment of patients with CAD [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cortese B, Bertoletti A. Paclitaxel coated balloons for coronary artery interventions: a comprehensive review of preclinical and clinical data. Int J Cardiol. 2012;161(1):4–12.

    Article  Google Scholar 

  2. Belkacemi A, Agostoni P, Voskuil M, Stella PR. Coronary bifurcation lesions treated with the drug-eluting balloon: a preliminary insight from the DEBIUT study. EuroIntervention. 2011;7:K66–9.

    Article  Google Scholar 

  3. Stella PR, Belkacemi A, Dubois C, et al. A multicenter randomized comparison of drug-eluting balloon plus bare-metal stent versus bare-metal stent versus drug-eluting stent in bifurcation lesions treated with a single-stenting technique: six-month angiographic and 12-month clinical results of the drug-eluting balloon in bifurcations trial. Catheter Cardiovasc Interv. 2012;80(7):1138–46.

    Article  Google Scholar 

  4. Schulz A, Hauschild T, Kleber FX. Treatment of coronary de novo bifurcation lesions with DCB only strategy. Clin Res Cardiol. 2014;103(6):451–6.

    Article  Google Scholar 

  5. Mínguez L, Ramón J, Asensio N, Manuel J, Vecino D, Javier L, et al. A prospective randomised study of the paclitaxel-coated balloon catheter in bifurcated coronary lesions (BABILON trial): 24-month clinical and angiographic results. EuroIntervention. 2014;10(1):50–7.

    Article  Google Scholar 

  6. Waksman R, Serra A, Loh JP, et al. Drug-coated balloons for de novo coronary lesions: results from the valentines II trial. EuroIntervention. 2013;9(5):613–9.

    Article  Google Scholar 

  7. Worthley S, Hendriks R, Worthley M, et al. Paclitaxel-eluting balloon and everolimus-eluting stent for provisional stenting of coronary bifurcations: 12-month results of the multicenter BIOLUX-I study. Cardiovasc Revasc Med. 2015;16(7):413–7.

    Article  Google Scholar 

  8. Berland J, Lefèvre T, Brenot P, Fajadet J. DANUBIO–a new drug-eluting balloon for the treatment of side branches in bifurcation lesions: six-month angiographic follow-up results of the DEBSIDE trial. EuroIntervention. 2015;11(8):868–76.

    Article  Google Scholar 

  9. Jim M-H, Lee M K-y, Fung R C-y, et al. Six month angiographic result of supplementary paclitaxel-eluting balloon deployment to treat side branch ostium narrowing (SARPEDON). Int J Cardiol. 2015;187:594–7.

    Article  Google Scholar 

  10. Cortese B, Berti S, Biondi-Zoccai G, et al. Drug-coated balloon treatment of coronary artery disease: a position paper of the Italian Society of Interventional Cardiology. Catheter Cardiovasc Interv. 2014;83(3):427–35.

    Article  Google Scholar 

  11. Kleber FX, Mathey DG, Rittger H, et al. How to use the drug-eluting balloon: recommendations by the German consensus group. EuroIntervention. 2011;7:K125–8.

    Article  Google Scholar 

  12. Picard F, Doucet S, Asgar AW. Contemporary use of drug-coated balloons in coronary artery disease: where are we now? Arch Cardiovasc Dis. 2017;110(4):259–72.

    Article  Google Scholar 

  13. Cortese B. The PICCOLETO study and beyond. EuroIntervention. 2011;7:K53–6.

    Article  Google Scholar 

  14. Bondesson P, Lagerqvist B, James SK, et al. Comparison of two drug-eluting balloons: a report from the SCAAR registry. EuroIntervention. 2012;8(4):444–9.

    Article  Google Scholar 

  15. Unverdorben M, Kleber FX, Heuer H, et al. Treatment of small coronary arteries with a paclitaxel-coated balloon catheter in the PEPCAD I study: are lesions clinically stable from 12 to 36 months? EuroIntervention. 2013;9(5):620–8.

    Article  Google Scholar 

  16. Zeymer U, Waliszewski M, Spiecker M, et al. Prospective ‘real world’ registry for the use of the ‘PCB only’ strategy in small vessel de novo lesions. Heart. 2013;100(4):311–6.

    Article  Google Scholar 

  17. Cortese B, Fetiveau R, Carrera A, et al. TCT-417 treatment of coronary artery disease with a new-generation drug-coated balloon: preliminary results from the Italian Elutax SV registry. J Am Coll Cardiol. 2015;15(66):B169–70.

    Article  Google Scholar 

  18. Teo LYL, Khurana R, Jafary FH, Ooi YW. Clinical efficacy and safety of sequent please paclitaxel-eluting balloon in a real-world multi-center registry of south-east Asian patients. Am J Cardiol. 2013;111(7):28B.

    Google Scholar 

  19. Uhlemann M, Möbius-Winkler S, Adam J, et al. The Leipzig prospective drug-eluting balloon-registry—outcome of 484 consecutive patients treated for coronary in-stent restenosis and De novo lesions using paclitaxel-coated balloons. Circ J. 2016;80(2):379–86.

    Article  Google Scholar 

  20. Latib A, Colombo A, Castriota F, et al. A randomized multicenter study comparing a paclitaxel drug-eluting balloon with a paclitaxel-eluting stent in small coronary vessels: the BELLO (balloon elution and late loss optimization) study. J Am Coll Cardiol. 2012;60(24):2473–80.

    Article  CAS  Google Scholar 

  21. Latib A, Ruparelia N, Menozzi A, et al. 3-year follow-up of the balloon elution and late loss optimization study (BELLO). J Am Coll Cardiol Interv. 2015;8(8):1132–4.

    Article  Google Scholar 

  22. Richelsen RKB, Overvad TF, Jensen SE. Drug-eluting balloons in the treatment of coronary De novo lesions: a comprehensive review. Cardiol Ther. 2016;5(2):133–60.

    Article  Google Scholar 

  23. Cortese B, D’Ascenzo F, Fetiveau R, et al. Treatment of coronary artery disease with a new-generation drug-coated balloon: final results of the Italian Elutax SV rEgistry-DCB-RISE. J Cardiovasc Med (Hagerstown). 2018;19(5):247–52.

    Article  CAS  Google Scholar 

  24. Giannini F, Naim C, Costopoulos C, et al. Drug-coated balloons in interventional cardiology. Expert Rev Cardiovasc Ther. 2013;11(10):1379–91.

    Article  CAS  Google Scholar 

  25. Belkacemi A, Agostoni P, Nathoe HM, et al. First results of the DEB-AMI (drug eluting balloon in acute ST-segment elevation myocardial infarction) trial. J Am Coll Cardiol. 2012;59(25):2327–37.

    Article  Google Scholar 

  26. Nijhoff F, Agostoni P, Belkacemi A, et al. Primary percutaneous coronary intervention by drug-eluting balloon angioplasty: the nonrandomized fourth arm of the DEB-AMI (drug-eluting balloon in ST-segment elevation myocardial infarction) trial. Catheter Cardiovasc Interv. 2015;86(S1):S34–44.

    Article  Google Scholar 

  27. Vos NS, van der Schaaf RJ, Amoroso G, et al. REVascularization with paclitaxEL-coated balloon angioplasty versus drug-eluting stenting in acute myocardial infarcTION—A randomized controlled trial: rationale and design of the REVELATION trial. Catheter Cardiovasc Interv. 2016;87(7):1213–21.

    Article  Google Scholar 

  28. Gao L, Chen Y-D. Application of drug-coated balloon in coronary artery intervention: challenges and opportunities. J Geriatr Cardiol. 2016;13(11):906–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Waksman R, Pakala R. Drug-eluting balloon: the comeback kid? Circ Cardiovasc Interv. 2009;2(4):352–8.

    Article  CAS  Google Scholar 

  30. Calé R, Sousa PJ, Pereira E, et al. One-year clinical outcomes of percutaneous treatment with drug-eluting balloons: results from a multicenter registry. Rev Port Cardiol. 2013;32(5):361–9.

    Article  Google Scholar 

  31. Maier LS, Maack C, Ritter O, Böhm M. Hotline update of clinical trials and registries presented at the German Cardiac Society meeting 2008. (PEPCAD, LokalTax, INH, German ablation registry, German device registry, DES.DE registry, DHR, reality, SWEETHEART registry, ADMA, GERSHWIN). Clin Res Cardiol. 2008;97(6):356–63.

    Article  CAS  Google Scholar 

  32. Xiu PY, Meier P. What are the barriers to the use of drug-eluting balloons? Interv Cardiol. 2014;6(1):9.

    Article  Google Scholar 

  33. Cortese B, Silva Orrego P, Agostoni P, et al. Effect of drug-coated balloons in native coronary artery disease left with a dissection. J Am Coll Cardiol Intv. 2015;8(15):2003–9.

    Article  Google Scholar 

  34. Wickramarachchi U, Eccleshall S. Drug-coated balloon-only angioplasty for native coronary disease instead of stents. Interv Cardiol Rev. 2016;11(2):110–5.

    Google Scholar 

  35. Raban V, Ahmed F, Ohlow MA, et al. Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial. Lancet. 2018;6736(18):31719–7.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

    Mostafa Elwany

  2. Cardiac Department, San Carlo Clinic, Milano, Italy

    Bernardo Cortese

Authors
  1. Mostafa Elwany
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernardo Cortese
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cardiac Department, San Carlo Clinic, Milano, Italy

    Bernardo Cortese

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Elwany, M., Cortese, B. (2019). Drug-Coated Balloons in Native Coronary Artery Disease. In: Cortese, B. (eds) Drug-Coated Balloons . Springer, Cham. https://doi.org/10.1007/978-3-319-92600-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-92600-1_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-92599-8

  • Online ISBN: 978-3-319-92600-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation