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Systems-Level Analysis of Bacterial Regulatory Small RNA Networks

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Systems Biology

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

The RNA landscape of all sequenced bacteria is littered with regulatory noncoding small RNAs (sRNA). Understanding the functions of these sRNAs has lagged behind their identification, as few high-throughput approaches existed to capture sRNA interactions in vivo. Recently, methodologies have been described that allow for profiling of the sRNA interaction network facilitating systems-level analysis sRNA regulation. This chapter discusses recent advances in our understanding of sRNA function, technical advances that allow us to capture sRNA interactions in vivo, and the computational tools that allow meaningful conclusions to be drawn from these data.

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Authors and Affiliations

  1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Julia Wong, Ignatius Pang, Marc Wilkins & Jai J. Tree

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  1. Julia Wong
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  2. Ignatius Pang
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  3. Marc Wilkins
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  4. Jai J. Tree
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Correspondence to Jai J. Tree .

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Editors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Berlin, Germany

    Nikolaus Rajewsky

  2. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  3. Polish Academy of Sciences, Institute of Bioorganic Chemistry, Poznań, Poland

    Jan Barciszewski

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Wong, J., Pang, I., Wilkins, M., Tree, J.J. (2018). Systems-Level Analysis of Bacterial Regulatory Small RNA Networks. In: Rajewsky, N., Jurga, S., Barciszewski, J. (eds) Systems Biology. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-92967-5_6

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