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A Deep Learning Method for Prediction of Benign Epilepsy with Centrotemporal Spikes

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Bioinformatics Research and Applications (ISBRA 2018)

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Abstract

Benign epilepsy with centrotemporal spikes (BECT) is the most common epilepsy in the children. The research of BECT mainly focuses on the comparative analysis of the BECT patients and the healthy controls. Different from the existing methods, we proposed a 3D convolution neural network (3DCNN) that directly predicts the disease of BECT from raw magnetic resonance imaging (MRI). The experiment shows our 3DCNN model get an \(89.80\%\) accuracy in the five-fold cross-validation evaluation which is over a large margin than the benchmark method.

Supported by the science and technology department of Sichuan province (No. 18MZGC0127).

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References

  1. Adebimpe, A., Aarabi, A., Bourel-Ponchel, E., Mahmoudzadeh, M., Wallois, F.: EEG resting state functional connectivity analysis in children with benign epilepsy with centrotemporal spikes. Front. Neurosci. 10, 143 (2016)

    Article  Google Scholar 

  2. Baglietto, M.G., Battaglia, F.M., Nobili, L., Tortorelli, S., De Negri, E., Calevo, M.G., Veneselli, E., De Negri, M.: Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or rolandic spikes. Dev. Med. Child Neurol. 43(6), 407–412 (2001)

    Article  Google Scholar 

  3. Beaussart, M.: Benign epilepsy of children with rolandic (centro-temporal) paroxysmal foci a clinical entity. Study of 221 cases. Epilepsia 13(6), 795–811 (1972)

    Article  Google Scholar 

  4. Boor, S., Vucurevic, G., Pfleiderer, C., Stoeter, P., Kutschke, G., Boor, R.: EEG-related functional MRI in benign childhood epilepsy with centrotemporal spikes. Epilepsia 44(5), 688–692 (2003)

    Article  Google Scholar 

  5. Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49

    Chapter  Google Scholar 

  6. Croona, C., Kihlgren, M., Lundberg, S., Eeg-Olofsson, O., Eeg-Olofsson, K.E.: Neuropsychological findings in children with benign childhood epilepsy with centrotemporal spikes. Dev. Med. Child Neurol. 41(12), 813–818 (1999)

    Article  Google Scholar 

  7. Doumlele, K., Friedman, D., Buchhalter, J., Donner, E.J., Louik, J., Devinsky, O.: Sudden unexpected death in epilepsy among patients with benign childhood epilepsy with centrotemporal spikes. JAMA Neurol. 74(6), 645–649 (2017)

    Article  Google Scholar 

  8. Garcia-Ramos, C., Jackson, D.C., Lin, J.J., Dabbs, K., Jones, J.E., Hsu, D.A., Stafstrom, C.E., Zawadzki, L., Seidenberg, M., Prabhakaran, V., et al.: Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia 56(10), 1615–1622 (2015)

    Article  Google Scholar 

  9. Gastaut, Y.: Un element deroutant de la semeiologie electroencephalographique: les pointes prerolandique sans signification focale. Rev. Neurol. 87, 408–490 (1952)

    Google Scholar 

  10. Gelisse, P., Corda, D., Raybaud, C., Dravet, C., Bureau, M., Genton, P.: Abnormal neuroimaging in patients with benign epilepsy with centrotemporal spikes. Epilepsia 44(3), 372–378 (2003)

    Article  Google Scholar 

  11. Liasis, A., Bamiou, D., Boyd, S., Towell, A.: Evidence for a neurophysiologic auditory deficit in children with benign epilepsy with centro-temporal spikes. J. Neural Transm. 113(7), 939–949 (2006)

    Article  Google Scholar 

  12. Neubauer, B., Fiedler, B., Himmelein, B., Kämpfer, F., Lässker, U., Schwabe, G., Spanier, I., Tams, D., Bretscher, C., Moldenhauer, K., et al.: Centrotemporal spikes in families with rolandic epilepsy linkage to chromosome 15q14. Neurology 51(6), 1608–1612 (1998)

    Article  Google Scholar 

  13. Yu, N., Li, Z., Yu, Z.: A survey on encoding schemes for genomic data representation and feature learning? From signal processing to machine learning. Big Data Min. Anal. 1(3), 23–40 (2018)

    MathSciNet  Google Scholar 

  14. Peng, S., You, R., Wang, H., Zhai, C., Mamitsuka, H., Zhu, S.: DeepMeSH: deep semantic representation for improving large-scale MeSH indexing. Bioinformatics 32(12), i70–i79 (2016)

    Article  Google Scholar 

  15. Roth, H.R., et al.: A new 2.5D representation for lymph node detection using random sets of deep convolutional neural network observations. In: Golland, P., Hata, N., Barillot, C., Hornegger, J., Howe, R. (eds.) MICCAI 2014. LNCS, vol. 8673, pp. 520–527. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10404-1_65

    Chapter  Google Scholar 

  16. Uliel-Sibony, S., Kramer, U.: Benign childhood epilepsy with centro-temporal spikes (BCECTSs), electrical status epilepticus in sleep (ESES), and academic decline? How aggressive should we be? Epilepsy Behav. 44, 117–120 (2015)

    Article  Google Scholar 

  17. Zeng, H., Ramos, C.G., Nair, V.A., Hu, Y., Liao, J., La, C., Chen, L., Gan, Y., Wen, F., Hermann, B., et al.: Regional homogeneity (ReHo) changes in new onset versus chronic benign epilepsy of childhood with centrotemporal spikes (BECTs): a resting state fMRI study. Epilepsy Res. 116, 79–85 (2015)

    Article  Google Scholar 

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Correspondence to Ling Liu or Yi Pan .

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Yan, M., Liu, L., Chen, S., Pan, Y. (2018). A Deep Learning Method for Prediction of Benign Epilepsy with Centrotemporal Spikes. In: Zhang, F., Cai, Z., Skums, P., Zhang, S. (eds) Bioinformatics Research and Applications. ISBRA 2018. Lecture Notes in Computer Science(), vol 10847. Springer, Cham. https://doi.org/10.1007/978-3-319-94968-0_24

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  • DOI: https://doi.org/10.1007/978-3-319-94968-0_24

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  • Online ISBN: 978-3-319-94968-0

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