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Treatment of Multiple System Atrophy

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Therapy of Movement Disorders

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Multiple system atrophy is a neurodegenerative disorder (one of the atypical parkinsonian syndromes) characterized by the presence of akinetic-rigid parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. Other features include REM sleep behavior disorder, respiratory stridor, disproportionate anterocollis, orofacial dystonia, and mood disorder. There are no diagnostic tests available. There are also no disease-modifying treatments. Treatment is symptomatic. This chapter will review clinical diagnosis and the roles of levodopa, botulinum toxin injections, nonmedical and medical approaches to urinary incontinence, constipation and orthostatic hypotension, as well as antidepressants and anxiolytics for symptomatic treatment.

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Authors and Affiliations

  1. Vance Lanier Chair of Neurology, Department of Neurology, Jean and Paul Amos Parkinson’s Disease and Movement Disorder Program, Emory University, Atlanta, GA, USA

    Stewart A. Factor DO

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  1. Stewart A. Factor DO
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Correspondence to Stewart A. Factor DO .

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Editors and Affiliations

  1. The Frederick Henry Prince Distinguished, Professor in Neurology, Department of Neurology, University of Maryland, Baltimore, Baltimore, MD, USA

    Stephen G. Reich

  2. Vance Lanier Chair of Neurology, Professor, Department of Neurology, Director, Jean and Paul Amos Parkinson’s Disease and Movement Disorder Program, Emory University, Atlanta, GA, USA

    Stewart A. Factor

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Factor, S.A. (2019). Treatment of Multiple System Atrophy. In: Reich, S., Factor, S. (eds) Therapy of Movement Disorders. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-319-97897-0_33

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  • DOI: https://doi.org/10.1007/978-3-319-97897-0_33

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-319-97896-3

  • Online ISBN: 978-3-319-97897-0

  • eBook Packages: MedicineMedicine (R0)

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