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Future Directions in Clinical Research Informatics

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Clinical Research Informatics

Part of the book series: Health Informatics ((HI))

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Abstract

Given the rapid advances in biomedical science, the growth of the human population, and the escalating costs of health care, the need to accelerate the pace of biomedical discoveries and their translation into health-care practice will continue to grow. Indeed, the need for more efficient and effective support of clinical research to enable the development, evaluation, and implementation of cost-effective therapies is more important now than ever before. Furthermore, the fundamentally information-intensive nature of such clinical research endeavors and the growth in both health technology adoption and health-related data available for interventions and analytics beg for the solutions offered by CRI. As a result, the demand for informatics professionals who focus on the increasingly important field of clinical and translational research will increase. Despite the progress made to date, new models, tools, and approaches will be needed to fully leverage and mine these digital assets and improve CRI practice, and this innovation will continue to drive the field forward in the coming years.

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References

  1. Embi PJ, Payne PR. Clinical research informatics: challenges, opportunities and definition for an emerging domain. J Am Med Inform Assoc. 2009;16(3):316–27.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Zerhouni EA. Translational and clinical science – time for a new vision. N Engl J Med. 2005;353(15):1621–3.

    Article  CAS  PubMed  Google Scholar 

  3. Zerhouni EA. Clinical research at a crossroads: the NIH roadmap. J Investig Med. 2006;54(4):171–3.

    Article  PubMed  Google Scholar 

  4. NCATS. CTSA Trial Innovation Network. https://ncats.nih.gov/ctsa/projects/network.

  5. Bourne PE, Bonazzi V, Dunn M, Green ED, Guyer M, Komatsoulis G, Larkin J, Russell B. The NIH big data to knowledge (BD2K) initiative. J Am Med Inform Assoc. 2015;22(6):1114. https://doi.org/10.1093/jamia/ocv136. No abstract available.

    Article  PubMed  PubMed Central  Google Scholar 

  6. NIH Strategic Plan: https://www.nih.gov/sites/default/files/about-nih/strategic-plan-fy2016-2020-508.pdf.

  7. Oster S, Langella S, Hastings S, et al. caGrid 1.0: an enterprise grid infrastructure for biomedical research. J Am Med Inform Assoc. 2008;15(2):138–49.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Saltz J, Oster S, Hastings S, et al. caGrid: design and implementation of the core architecture of the cancer biomedical informatics grid. Bioinformatics. 2006;22(15):1910–6.

    Article  CAS  PubMed  Google Scholar 

  9. Niland JC, Townsend RM, Annechiarico R, Johnson K, Beck JR, Manion FJ, Hutchinson F, Robbins RJ, Chute CG, Vogel LH, Saltz JH, Watson MA, Casavant TL, Soong SJ, Bondy J, Fenstermacher DA, Becich MJ, Casagrande JT, Tuck DP. The cancer biomedical informatics grid (caBIG): infrastructure and applications for a worldwide research community. Fortschr Med. 2007;12(Pt 1):330–4. PMID: 17911733.

    Google Scholar 

  10. Kakazu KK, Cheung LW, Lynne W. The cancer biomedical informatics grid (caBIG): pioneering an expansive network of information and tools for collaborative cancer research. Hawaii Med J. 2004;63(9):273–5.

    PubMed  Google Scholar 

  11. Citation to clinicaltrials.gov final rule: https://prsinfo.clinicaltrials.gov.

  12. Citation to common rule change: https://www.hhs.gov/ohrp/regulations-and-policy/regulations/finalized-revisions-common-rule/index.html.

  13. Holve E, Segal C, Lopez MH, Rein A, Johnson BH. The electronic data methods (EDM) forum for comparative effectiveness research (CER). Med Care. 2012;50(Suppl):S7–10. https://doi.org/10.1097/MLR.0b013e318257a66b.

    Article  PubMed  Google Scholar 

  14. Fleurence RL, Curtis LH, Califf RM, Platt R, Selby JV, Brown JS. Launching PCORnet, a national patient-centered clinical research network. J Am Med Inform Assoc. 2014;21(4):578–82. https://doi.org/10.1136/amiajnl-2014-002747. Epub 2014 May 12.

    Article  PubMed  PubMed Central  Google Scholar 

  15. PCORnet PPRN Consortium, Daugherty SE, Wahba S, Fleurence R. Patient-powered research networks: building capacity for conducting patient-centered clinical outcomes research. J Am Med Inform Assoc. 2014;21(4):583–6. https://doi.org/10.1136/amiajnl-2014-002758. Epub 2014 May 12.

    Article  PubMed Central  Google Scholar 

  16. Califf RM. The patient-centered outcomes research network: a national infrastructure for comparative effectiveness research. N C Med J. 2014;75(3):204–10. https://www.ncbi.nlm.nih.gov/pubmed/24830497.

    PubMed  Google Scholar 

  17. Hripcsak G, Duke JD, Shah NH, Reich CG, Huser V, Schuemie MJ, Suchard MA, Park RW, Wong IC, Rijnbeek PR, van der Lei J, Pratt N, Norén GN, Li YC, Stang PE, Madigan D, Ryan PB. Observational Health Data Sciences and Informatics (OHDSI): opportunities for observational researchers. Stud Health Technol Inform. 2015;216:574–8. PMID:26262116.

    PubMed  PubMed Central  Google Scholar 

  18. Klann JG, Abend A, Raghavan VA, Mandl KD, Murphy SN. Data interchange using i2b2. J Am Med Inform Assoc. 2016;23(5):909–15. https://doi.org/10.1093/jamia/ocv188. Epub 2016 Feb 5. PMID: 26911824.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Friedman CP, Wong AK, Blumenthal D. Achieving a nationwide learning health system. Sci Transl Med. 2010;2(57):57cm29.

    Article  PubMed  Google Scholar 

  20. Embi PJ, Payne PR. Evidence generating medicine: redefining the research-practice relationship to complete the evidence cycle. Med Care. 2013;51(8 Suppl 3):S87–91. https://doi.org/10.1097/MLR.0b013e31829b1d66. PMID: 23793052.

    Article  PubMed  Google Scholar 

  21. Payne PR, Embi PJ, Niland J. Foundational biomedical informatics research in the clinical and translational science era: a call to action. J Am Med Inform Assoc. 2010;17(6):615–6.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Richesson RL, Green BB, Laws R, Puro J, Kahn MG, Bauck A, Smerek M, Van Eaton EG, Zozus M, Hammond WE, Stephens KA, Simon GE. Pragmatic (trial) informatics: a perspective from the NIH health care systems research collaboratory. J Am Med Inform Assoc. 2017;24(5):996–1001. https://doi.org/10.1093/jamia/ocx016.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Embi PJ, Kaufman SE, Payne PRO. Biomedical informatics and outcomes research. Circulation. 2009;120:2393–9., Originally published December 7, 2009. https://doi.org/10.1161/CIRCULATIONAHA.108.795526.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Payne PR, Johnson SB, Starren JB, Tilson HH, Dowdy D. Breaking the translational barriers: the value of integrating biomedical informatics and translational research. J Investig Med. 2005;53(4):192–200.

    Article  PubMed  Google Scholar 

  25. Sung NS, Crowley WF Jr, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289(10):1278–87.

    Article  PubMed  Google Scholar 

  26. Chung TK, Kukafka R, Johnson SB. Reengineering clinical research with informatics. J Investig Med. 2006;54(6):327–33.

    Article  PubMed  Google Scholar 

  27. Sanchez-Pinto LN1, Mosa ASM, Fultz-Hollis K, Tachinardi U, Barnett WK, Embi PJ. The emerging role of the chief research informatics officer in academic health centers. Appl Clin Inform. 2017;8(3):845–53. https://doi.org/10.4338/ACI-2017-04-RA-0062.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Embi PJ, Payne PR. Advancing methodologies in clinical research informatics (CRI): foundational work for a maturing field. J Biomed Inform. 2014;52:1–3. https://doi.org/10.1016/j.jbi.2014.10.007. No abstract available.

    Article  PubMed  Google Scholar 

  29. Payne PRO, Embi PJ, editors. Translational informatics: realizing the promise of knowledge-driven healthcare. London: Springer; 2014.

    Google Scholar 

  30. The Ohio State University-AMIA 10x10 program in Clinical Research Informatics. http://www.amia.org/education/academic-and-training-programs/10x10-ohio-state-university. Accessed 14 Jul 2011.

  31. Knosp BM, Barnett W, Embi PJ, Anderson N. Maturity models for research IT and Informatics reports from the field. In:Proceedings of the AMIA summit on clinical research informatics; 2017. p. 18–20. https://knowledge.amia.org/amia-64484-cri2017-1.3520710/t001-1.3521784/t001-1.3521785/a011-1.3521792/ap011-1.3521793#pdf-container.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Regenstrief Institute, Inc, and Indiana University School of Medicine, Indianapolis, IN, USA

    Peter J. Embi MD, MS

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  1. Peter J. Embi MD, MS
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Correspondence to Peter J. Embi MD, MS .

Editor information

Editors and Affiliations

  1. Duke University School of Nursing, Durham, NC, USA

    Rachel L. Richesson

  2. School of Information, University of South Florida, Tampa, FL, USA

    James E. Andrews

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Embi, P.J. (2019). Future Directions in Clinical Research Informatics. In: Richesson, R., Andrews, J. (eds) Clinical Research Informatics. Health Informatics. Springer, Cham. https://doi.org/10.1007/978-3-319-98779-8_22

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  • DOI: https://doi.org/10.1007/978-3-319-98779-8_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98778-1

  • Online ISBN: 978-3-319-98779-8

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