Abstract
Drug absorption is essential for a systemic medication to elicit its pharmacological response. The extent and rate of drug absorption have a direct impact on drug bioavailability. Here, we describe the key factors influencing drug absorption, the main mechanisms of drug absorption, and the most common models used to describe absorption kinetics. Examples and case studies are included.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Al-Mohizea A, Zawaneh F, Alam MA et al (2014) Effect of pharmaceutical excipients on the permeability of p-glycoprotein substrate. J Drug Deliv Sci Technol 24:491–495
Alberts B, Johnson A, Lewis J et al (2002) In: Alberts B, Johnson A, Lewis J et al (eds) Membrane structure. Garland Science, New York
Arulanantham N, Lee RW, Hayton T (2014) Lesson of the month 2: a case of coma in a Parkinson's patient: a combination of fatigue, dehydration and high protein diet over the new year period? Clin Med (Lond) 14:449–451
Barichella M, Cereda E, Cassani E et al (2017) Dietary habits and neurological features of Parkinson’s disease patients: implications for practice. Clin Nutr 36:1054–1061
Bazzoni G (2006) Endothelial tight junctions: permeable barriers of the vessel wall. Thromb Haemost 95:36–42
Broër S (2008) Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev 88:249–286
Falcon RW, Kakuda TN (2008) Drug interactions between HIV protease inhibitors and acid-reducing agents. Clin Pharmacokinet 47:75–89
González-Mariscal L, Betanzos A, Nava P et al (2003) Tight junction proteins. Prog Biophys Mol Biol 81:1–44
González-Mariscal L, Posadas Y, Miranda J et al (2017) Strategies that target tight junctions for enhanced drug delivery. Curr Pharm Des 22:5313–5346
Hodaei D, Baradaran B, Valizadeh H et al (2014) The effect of tween excipients on expression and activity of p-glycoprotein in Caco-2 cells. Pharm Ind 76:788–794
Johansson MEV, Sjövall H, Hansson GC et al (2013) The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol 10:5352–5361
Lewis JM, Stott KE, Monnery D et al (2016) Managing potential drug-drug interactions between gastric acid-reducing agents and antiretroviral therapy: experience from a large HIV-positive cohort. Int J STD AIDS 27:105–109
Panitchob N, Widdows IP, Crocker MA et al (2015) Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles. J Theor Biol 365:352–364
Sobue S, Sekiguchi K, Kikkawa H et al (2006) Comparison of nicotine pharmacokinetics in healthy Japanese male smokers following application of the transdermal nicotine patch and cigarette smoking. Biol Pharm Bull 29:1068–1073
Singer SJ, Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175:720–731
Sultatos L (2011) In: Enna SJ, Bylund DB (eds) Drug absorption from the gastrointestinal tract. Elsevier, Boston, pp 1–2
Tompkins L, Lynch C, Haidar S et al (2010) Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res 27:1703–1712
Tomilo DL, Smith PF, Ogundele AB et al (2006) Inhibition of atazanavir oral absorption by lansoprazole gastric acid suppression in healthy volunteers. Pharmacotherapy 26:341–346
Van Itallie CM, Anderson JM (2004) The molecular physiology of tight junction pores. Physiology (Bethesda) 19:331–338
Wang L, Xiong N, Huang J et al (2017) Protein-restricted diets for ameliorating motor fluctuations in Parkinson’s disease. Front Aging Neurosci 9:206
Further Reading
The reader is referred to the wonderful volume by Carsten Ehrhardt and Kwan-Jin Kim for additional insight on the absorption process with a focus on experimental and computational models of absorption (Drug Absorption Studies. In Situ, In Vitro and In Silico models, Springer, 2008). The Molecular Biopharmaceutics volume by Bente Steffansen et al. is also highly recommended to study experimental models of drug absorption (Molecular Biopharmaceutics, Pharmaceutical Press, 2010)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Talevi, A., Bellera, C.L. (2018). Drug Absorption. In: Talevi, A., Quiroga, P. (eds) ADME Processes in Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-99593-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-99593-9_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99592-2
Online ISBN: 978-3-319-99593-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)