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Diagnostic Imaging – Positron Emission Tomography, Combined PET/CT Imaging

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Osteomyelitis of the Jaws

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Abstract

Positron emission tomography (PET) is a relatively new non-invasive technique to investigate various bone and soft tissue pathologies. The combination of PET scanners and radioactive tracing substances, nowadays most commonly fluorine-18-fluoro-2-deoxy-D-glucose (18FDG), provides three-dimensional images in very short time depicting biological activity rather than anatomy; however, 18FDG does not only accumulate in osteomyelitis of the jaws but also in many other conditions such as fractures, malignant tumors, and in sterile and non-sterile inflammations. Both accurate knowledge of concomitant diseases and therefore careful indication minimize false-positive results and guarantee high specificity and a good positive predictive value. The use of PET in osteomyelitis of the jaws has only been investigated recently and published data is very scarce. The development of fused PET/CT images is particularly promising since it combines the advantages of a detailed imaging of the anatomy combined with detection of local metabolic activity pattern; hence, for the first time, this technique offers simultaneously direct information of form and function of bone pathology. High costs and limited availability are the major drawbacks for PET and fused PET/CT investigation; however, as technology advances this imaging tool will inevitably become more widely used and experience will increase, making it a very promising diagnostic tool for assessment of osteomyelitis in the future.

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References

  • Alavi A. PET imaging I. Radiol Clin North Am 2004; 42(6):xi−xiii

    Article  PubMed  Google Scholar 

  • Buscombe JR. The future of infection imaging. Q J Nucl Med Mol Imaging 2006; 50(2):99−103

    PubMed  CAS  Google Scholar 

  • Crymes WB, Demos H, Gordon L. Detection of musculoskeletal infection with 18F-FDG PET: review of the current literature. J Nucl Med Technol 2004; 32(1):12−15

    PubMed  Google Scholar 

  • De Winter F, Vogelaers D, Gemmel F, Dierckx RA. Promising role of 18-F-fluoro-D-deoxyglucose positron emission tomography in clinical infectious diseases. Eur J Clin Microbiol Infect Dis 2002; 21(4):247−257

    Article  PubMed  Google Scholar 

  • Goerres GW, Stoeckli SJ, Schulthess GK von, Steinert HC. FDG PET for mucosal malignant melanoma of the head and neck. Laryngoscope 2002; 112(2):381−385

    Article  PubMed  Google Scholar 

  • Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L, Reske SN. Chronic osteomyelitis: detection with FDG PET and correlation with histopathologic findings. Radiology 1998a; 206(3):749−754

    CAS  Google Scholar 

  • Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L, Reske SN. Fluorine-18-FDG PET and technetium-99m antigranulocyte antibody scintigraphy in chronic osteomyelitis. J Nucl Med 1998b; 39(12):2145−2152

    CAS  Google Scholar 

  • Hakim SG, Bruecker CW, Jacobsen HC, Hermes D, Lauer I, Eckerele S, Froehlich A, Sieg P. The value of FDG−PET and bone scintigraphy with SPECT in the primary diagnosis and follow-up of patients with chronic osteomyelitis of the mandible [In Process Citation]. Int J Oral Maxillofac Surg 2006; 35(9):809−816

    Article  PubMed  CAS  Google Scholar 

  • Hustinx R, Smith RJ, Benard F, Rosenthal DI, Machtay M, Farber LA, Alavi A. Dual time point fluorine-18 fluorodeoxyglucose positron emission tomography: a potential method to differentiate malignancy from inflammation and normal tissue in the head and neck. Eur J Nucl Med 1999; 26(10):1345−1348

    Article  PubMed  CAS  Google Scholar 

  • Kaim AH, Weber B, Kurrer MO, Gottschalk J, Schulthess GK von, Buck A. Autoradiographic quantification of 18F-FDG uptake in experimental soft-tissue abscesses in rats. Radiology 2002; 223(2):446−451

    Article  PubMed  Google Scholar 

  • Kallicke T, Schmitz A, Risse JH, Arens S, Keller E, Hansis M, Schmitt O, Biersack HJ, Grunwald F. Fluorine-18 fluorodeoxyglucose PET in infectious bone diseases: results of histologically confirmed cases. Eur J Nucl Med 2000; 27(5):524−528

    Article  Google Scholar 

  • Keidar Z, Militianu D, Melamed E, Bar-Shalom R, Israel O. The diabetic foot: initial experience with 18F-FDG PET/CT. J Nucl Med 2005; 46(3):444−449

    PubMed  Google Scholar 

  • Kohlfuerst S, Igerc I, Lind P. FDG PET helpful for diagnosing SAPHO syndrome. Clin Nucl 2003; 28(10):838−839

    Article  Google Scholar 

  • Koort JK, Makinen TJ, Knuuti J, Jalava J, Aro HT. Comparative 18F-FDG PET of experimental Staphylococcus aureus osteomyelitis and normal bone healing. J Nucl Med 2004; 45(8):1406−1411

    PubMed  Google Scholar 

  • Lewis PJ, Salama A. Uptake of fluorine-18-fluorodeoxyglucose in sarcoidosis. J Nucl Med 1994; 35:1647−1649

    PubMed  CAS  Google Scholar 

  • Love C, Tomas MB, Tronco GG, Palestro CJ. FDG PET of infection and inflammation. Radiographics 2005; 25(5):1357−1368

    Article  PubMed  Google Scholar 

  • Meller J, Koster G, Liersch T, Siefker U, Lehmann K, Meyer I, Schreiber K, Altenvoerde G, Becker R. Chronic bacterial osteomyelitis: prospective comparison of (18)F-FDG imaging with a dual-head coincidence camera and (111)In-labelled autologous leucocyte scintigraphy. Eur J Nucl Med Mol Imaging 2002; 29(1):53

    Article  PubMed  CAS  Google Scholar 

  • Meyer M, Gast T, Raja S, Hubner K. Increased F-18 FDG accumulation in an acute fracture. Clin Nucl Med 1994; 19(1):13−14

    Article  PubMed  CAS  Google Scholar 

  • Pauwels EK, Sturm EJ, Bombardieri E, Cleton FJ, Stokkel MP. Positron-emission tomography with [18F]fluorodeoxyglucose. Part I. Biochemical uptake mechanism and its implication for clinical studies. J Cancer Res Clin Oncol 2000; 126(10):549−559

    Article  PubMed  CAS  Google Scholar 

  • Pichler R, Weiglein K, Schmekal B, Sfetsos K, Maschek W. Bone scintigraphy using Tc-99m DPD and F18-FDG in a patient with SAPHO syndrome. Scand J Rheumatol 2003; 32(1):58−60

    Article  PubMed  Google Scholar 

  • Ravenel JG, Gordon LL, Pope TL, Reed CE. FDG-PET uptake in occult acute pelvic fracture. Skeletal Radiol 2004; 33(2):99−101

    Article  PubMed  Google Scholar 

  • Schirrmeister H, Guhlmann A, Elsner K, Kotzerke J, Glatting G, Rentschler M, Neumaier B, Trager H, Nussle K, Reske SN. Sensitivity in detecting osseous lesions depends on anatomic localization: planar bone scintigraphy versus 18F PET. J Nucl Med 1999; 40(10):1623−1629

    PubMed  CAS  Google Scholar 

  • Schmid DT, Stoeckli SJ, Bandhauer F, Huguenin P, Schmid S, Schulthess GK von, Goerres GW. Impact of positron emission tomography on the initial staging and therapy in locoregional advanced squamous cell carcinoma of the head and neck. Laryngoscope 2003; 113(5):888−891

    Article  PubMed  Google Scholar 

  • Stumpe KD, Strobel K. 18F FDG-PET imaging in musculoskeletal infection. Q J Nucl Med Mol Imaging 2006; 50(2):131−142

    PubMed  CAS  Google Scholar 

  • Stumpe KD, Dazzi H, Schaffner A, Schulthess GK von. Infection imaging using whole-body FDG-PET. Eur J Nucl Med 2000; 27(7):822−832

    Article  PubMed  CAS  Google Scholar 

  • Sugawara Y, Braun DK, Kison PV, Russo JE, Zasadny KR, Wahl RL. Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results. Eur J Nucl Med 1998; 25(9):1238−1243

    Article  PubMed  CAS  Google Scholar 

  • Taylor IK, Hill AA, Hayes M et al. Imaging allergen-invoked airway inflammation in atopic asthma with [18F]-fluorodeoxyglucose and positron emission tomography. Lancet 1996; 347(9006):937−940

    Article  PubMed  CAS  Google Scholar 

  • Temmerman OP, Heyligers IC, Hoekstra OS, Comans EF, Roos JC. Detection of osteomyelitis using FDG and positron emission tomography. J Arthroplasty 2001; 16(2):243−246

    Article  PubMed  CAS  Google Scholar 

  • Termaat MF, Raijmakers PG, Scholten HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am 2005; 87(11):2464−2471

    Article  PubMed  CAS  Google Scholar 

  • Yamada S, Kubota K, Kubota R, Ido T, Tamahashi N. High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. J Nucl Med 1995; 36(7):1301−1306

    PubMed  CAS  Google Scholar 

  • Zhuang H, Duarte PS, Pourdehand M, Shnier D, Alavi A. Exclusion of chronic osteomyelitis with F-18 fluorodeoxyglucose positron emission tomographic imaging. Clin Nucl Med 2000; 25(4):281−284

    Article  PubMed  CAS  Google Scholar 

  • Zhuang H, Sam JW, Chacko TK, Duarte PS, Hickeson M, Feng Q, Nakhoda KZ, Guan L, Reich P, Altimari SM, Alavi A. Rapid normalization of osseous FDG uptake following traumatic or surgical fractures. Eur J Nucl Med Mol Imaging 2003; 30(8):1096−1103

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinic of Cranio-Maxillofacial Surgery, University Zurich Medical Center, Rämistrasse 100, 8091, Zurich, Switzerland

    Andrej Terziċ & Gerhard Goerres

Authors
  1. Andrej Terziċ
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  2. Gerhard Goerres
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Editors and Affiliations

  1. Center for Jaw Surgery and Facial Plastic Surgery, Zürcherstrasse 7, 8400, Winterthur, Switzerland

    Marc M. Baltensperger

  2. Maxillofacial, Facial Plastic, Head and Neck Surgery, Oberdorfstrasse 41, 8853, Lachen, Switzerland

    Gerold K. H. Eyrich

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© 2009 Springer-Verlag Berlin Heidelberg

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Terziċ, A., Goerres, G. (2009). Diagnostic Imaging – Positron Emission Tomography, Combined PET/CT Imaging. In: Baltensperger, M., Eyrich, G. (eds) Osteomyelitis of the Jaws. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-28766-7_5

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  • DOI: https://doi.org/10.1007/978-3-540-28766-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-28764-3

  • Online ISBN: 978-3-540-28766-7

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