Abstract
The experimental characterization of novel genes is a tedious and expensive process. While computational gene characterization cannot replace wet lab studies, it has the potential of providing valuable guidance for experimental biologists. We use the novel IL28A,B and IL29 cytokine family to illustrate an approach to the computational identification and characterization of putative transcriptional regulatory regions that utilizes a combination of known and novel techniques. We then apply the approach, which we dubbed Orthocluster, to screen putative regulatory regions of a set of annotated RefSeq mRNA sequences. The encouraging results obtained for known genes motivate the analysis of novel or uncharacterized genes, which is one focus of our current work.
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Krivan, W. (2005). Fishing for Proteins in the Pacific Northwest. In: Eskin, E., Workman, C. (eds) Regulatory Genomics. RRG 2004. Lecture Notes in Computer Science(), vol 3318. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-32280-1_3
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DOI: https://doi.org/10.1007/978-3-540-32280-1_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-24456-1
Online ISBN: 978-3-540-32280-1
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