Abstract
Osteoporotic fracture is very common in aged population, with an average of 1–3% increase per year in most areas of the world because of increase in aging population. Fixation of osteoporotic fracture is difficult, often with implant loosening or backout. Fixation enhancement with various biomaterials and implants is investigated before clinical application. This chapter describes a study investigating the effect of an optimized injectable hydroxyapatite (HA) on enhancing screw fixation in osteoporotic bones. By using radiography, pQCT and micro-CT, the development of osteoporosis in ovariectomized Chinese goats was confirmed. There was an averaged 25% decrease of bone mineral density in the goats after 6-month ovariectomy as well as a significant reduction of trabecular thickness and connectivity. The established osteoporotic goat model was then used for evaluating the efficacy of an optimized injectable HA in screw fixation. With the application of micro-CT and histomorphometry, it was confirmed that the injectable HA was distributed evenly along the screw threads and new bone formation was detected on HA surface without fibrous tissues. The HA increased the contact area between implants and trabecular bones, and hence the holding power to screws. Mechanical test further confirmed the significant increase of screw pull-out force by HA. This study demonstrated the application of multiple non-invasive bioimaging technologies in biomaterial research.
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Cheung, WH., Qin, L., Tam, KF., Siu, WS., Leung, KS. (2007). Enhancement of Osteoporotic Bone Using Injectable Hydroxyapatite in OVX Goats Evaluated by Multi-imaging Modalities. In: Qin, L., Genant, H.K., Griffith, J.F., Leung, K.S. (eds) Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45456-4_32
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DOI: https://doi.org/10.1007/978-3-540-45456-4_32
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