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MR60/ERGIC-53, a Mannose-Specific Shuttling Intracellular Membrane Lectin

  • Chapter
Mammalian Carbohydrate Recognition Systems

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 33))

Abstract

Monocyte-derived macrophages express a mannoside-specific membrane lectin (Man-R) at their surface, which efficiently binds and internalizes mannosylated proteins as well as mannans (for reviews, see Stahl et al. 1984, Stahl 1992, and Taylor, this Vol.); conversely, monocytes and their precursors do not express this lectin. Knowing that the majority (80%) of the Man-R is located inside the cells and that its surface expression occurs during the first few hours of differentiation into macrophages, coming from an intracellular precursor protein pool (Lennartz et al. 1987), we decided to look for the presence of an intracellular precursor in two immature cell lines, the human promyelocytic cells HL60 and the human promonocytic cells U937, by using fluorescent neoglycoproteins.

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  1. Glycobiologie. Centre de Biophysique Moléculaire, CNRS and University of Orléans, Rue Charles Sadron, 45071, Orléans cedex 02, France

    Annie-Claude Roche & Michel Monsigny

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  1. Annie-Claude Roche
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  2. Michel Monsigny
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  1. The Wellcome Trust Building, Dept. of Biochemistry, University of Dundee, DD1 4HN, Dundee, Scotland

    Paul R. Crocker

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Roche, AC., Monsigny, M. (2001). MR60/ERGIC-53, a Mannose-Specific Shuttling Intracellular Membrane Lectin. In: Crocker, P.R. (eds) Mammalian Carbohydrate Recognition Systems. Results and Problems in Cell Differentiation, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46410-5_2

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  • DOI: https://doi.org/10.1007/978-3-540-46410-5_2

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