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Regulation of the Cytoskeleton Assembly: a Role for a Ternary Complex of Actin with Two Actin-Binding Proteins

  • Chapter
Molecular Interactions of Actin

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 32))

Abstract

The actin cytoskeleton is an essential component of all eukaryotic cells. Besides its role in cell motility, it has a number of other functions, including cytokinesis, signal transduction, and the maintenance of cell shape. An essential property of the cytoskeleton is its ability to rapidly assemble and disassemble monomers of actin into F-actin filaments and this process is now known to be regulated by a number of actin-binding proteins (ABPs) of which cofilin appears to be the most widely distributed in nature. In this chapter we pose the question: does cofilin act alone in controlling actin filament assembly or is the binding of cofilin to actin modulated by other ABPs?

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Author information

Authors and Affiliations

  1. Muscle Research Unit, Institute for Biomedical Research F13, Department of Anatomy and Histology, The University of Sydney, 2006, Sydney, Australia

    Murat Kekic, Neil J. Nosworthy, Irina Dedova & Cristobal G. dos Remedios

  2. Department of Biochemistry G08, The University of Sydney, 2006, Sydney, Australia

    Charles A. Collyer

Authors
  1. Murat Kekic
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  2. Neil J. Nosworthy
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  3. Irina Dedova
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  4. Charles A. Collyer
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  5. Cristobal G. dos Remedios
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Editor information

Editors and Affiliations

  1. Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, 2006, Sydney, Australia

    Cristobal G. dos Remedios

  2. Department of Biochemistry, University of Minnesota, 55455, Minneapolis, MN, USA

    David D. Thomas

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© 2001 Springer-Verlag Berlin Heidelberg

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Kekic, M., Nosworthy, N.J., Dedova, I., Collyer, C.A., dos Remedios, C.G. (2001). Regulation of the Cytoskeleton Assembly: a Role for a Ternary Complex of Actin with Two Actin-Binding Proteins. In: dos Remedios, C.G., Thomas, D.D. (eds) Molecular Interactions of Actin. Results and Problems in Cell Differentiation, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46560-7_12

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  • DOI: https://doi.org/10.1007/978-3-540-46560-7_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53675-5

  • Online ISBN: 978-3-540-46560-7

  • eBook Packages: Springer Book Archive

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