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Poly (lactic-co-glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

  • Conference paper
3rd Kuala Lumpur International Conference on Biomedical Engineering 2006

Part of the book series: IFMBE Proceedings ((IFMBE,volume 15))

Abstract

PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6th-day at culture in proliferation assaying, p<0.05).

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Author information

Authors and Affiliations

  1. Biomedical engineering, Inje University, Obang-Dong, Gim-hae, Korea

    Jeong Koo Kim

  2. Dept. of Biomedical engineering, Inje University, Gimhae, Korea

    J. B. Lee, C. W. Mun, H. H. Choi & Jeong Koo Kim

  3. Dept. of Medical Engineering, College of Medicine, Yonsei University, Seoul, Korea

    J. C. Park

  4. Dept. Mechanical Systems Eng., Hansung University, Seoul, Korea

    J. B. Choi

Authors
  1. J. B. Lee
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  2. C. W. Mun
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  3. H. H. Choi
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  4. J. C. Park
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  5. J. B. Choi
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  6. Jeong Koo Kim
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Fatimah Ibrahim , Noor Azuan Abu Osman , Juliana Usman  & Nahrizul Adib Kadri , ,  & 

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© 2007 Springer-Verlag Berlin Heidelberg

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Lee, J.B., Mun, C.W., Choi, H.H., Park, J.C., Choi, J.B., Kim, J.K. (2007). Poly (lactic-co-glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. In: Ibrahim, F., Osman, N.A.A., Usman, J., Kadri, N.A. (eds) 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006. IFMBE Proceedings, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68017-8_33

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  • DOI: https://doi.org/10.1007/978-3-540-68017-8_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-68016-1

  • Online ISBN: 978-3-540-68017-8

  • eBook Packages: EngineeringEngineering (R0)

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