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A Role for Signal Propagation Through the Hippocampal CA2 Field in Memory Formation

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Web Intelligence Meets Brain Informatics (WImBI 2006)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 4845))

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Abstract

Memory is very vivid and long-lasting, particularly when we have strong emotions, such as pleasure, love, fun, surprise, fear, anxiety and anger. This fact leads us to imagine that memory storage in the hippocampus can be switched according to the emotion-related brain state. In this paper, we first review the two classical concepts for the hippocampal network. One is the trisynaptic circuit connecting the entorhinal cortex, the dentate gyrus, the CA3 field and the CA1 field. The other is the lamellar hypothesis which proposes that the lamellar organization of the trisynaptic circuit. We then summarize our studies highlighting a role of the hippocampal CA2 field in memory formation. Finally we propose a novel circuit in the hippocampal network, which contains the CA3-CA2-CA1 pathway in which the CA2 field functions as a gate controlled by the activity of the supramammillary nucleus to control signal propagation between hippocampal lamellar organizations.

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Authors and Affiliations

  1. Division of Neuronal Network, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    Yuko Sekino

  2. Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan

    Tomoaki Shirao

  3. CREST, JST, Kawaguchi, Japan

    Yuko Sekino

Authors
  1. Yuko Sekino
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  2. Tomoaki Shirao
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Ning Zhong Jiming Liu Yiyu Yao Jinglong Wu Shengfu Lu Kuncheng Li

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Sekino, Y., Shirao, T. (2007). A Role for Signal Propagation Through the Hippocampal CA2 Field in Memory Formation. In: Zhong, N., Liu, J., Yao, Y., Wu, J., Lu, S., Li, K. (eds) Web Intelligence Meets Brain Informatics. WImBI 2006. Lecture Notes in Computer Science(), vol 4845. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77028-2_14

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  • DOI: https://doi.org/10.1007/978-3-540-77028-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77027-5

  • Online ISBN: 978-3-540-77028-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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