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Subversion of Cell Cycle Regulatory Pathways

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Human Cytomegalovirus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 325))

Human cytomegalovirus (HCMV) has evolved numerous strategies to commandeer the host cell for producing viral progeny. The virus manipulates host cell cycle pathways from the early stages of infection to stimulate viral DNA replication at the expense of cellular DNA synthesis. At the same time, cell cycle checkpoints are by-passed, preventing apoptosis and allowing sufficient time for the assembly of infectious virus.

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Author information

Authors and Affiliations

  1. Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, 77843, College Station, TX, USA

    V. Sanchez

  2. Department of Cellular and Molecular Medicine, University of California San Diego, 92093, La Jolla, CA, USA

    D. H. Spector

Authors
  1. V. Sanchez
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  2. D. H. Spector
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Editor information

Editors and Affiliations

  1. Princeton University, 08544-1014, Princeton, NJ, USA

    Thomas E. Shenk

  2. University of Iowa, 52242, Iowa, IA, USA

    Mark F. Stinski

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© 2008 Springer-Verlag Berlin Heidelberg

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Sanchez, V., Spector, D.H. (2008). Subversion of Cell Cycle Regulatory Pathways. In: Shenk, T.E., Stinski, M.F. (eds) Human Cytomegalovirus. Current Topics in Microbiology and Immunology, vol 325. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77349-8_14

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