Key Points
• Metastatic bone disease is the commonest bone malignancy in the adult ≥40 years of age.
• The occurrence of bone metastases is a sign of poor prognosis, and major complications due to bone metastases are common and include hypercalcaemia and pathological fracture.
• Fracture risk can be assessed utilising clinical criteria and radiographs using the Mirels score.
• Bone lesions, especially if solitary, cannot be assumed to be metastases even in patients with a known primary malignancy.
• Biopsies should be performed in a dedicated bone tumour centre.
• The main aim of all treatments must be to relieve pain and restore function; patient management benefits from a multidisciplinary approach.
• Follow-up imaging after treatment is challenging for the radiologist and requires detailed knowledge about the treatment and possible outcomes and complications.
• Bone metastases can occur within any bone in any location.
• The morphology of bone metastases is extremely varied and unspecific; in many cases histological confirmation is indicated.
• Radiographs are relatively insensitive and unspecific but still a valuable first-line investigation for focal pain.
• Bone scintigraphy is a simple and inexpensive screening test for bone metastases, but specificity and less so sensitivity are limited.
• PET–CT and whole-body MRI offer good sensitivity and specificity but are expensive and not universally available.
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Tins, B., Lalam, R., Cassar-Pullicino, V., Tyrrell, P. (2009). Bone Metastases 2: Pelvis and Appendicular Skeleton. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_27
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