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The WNT/β-Catenin Pathway

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Signaling Pathways in Liver Diseases

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Abstract

Genetic studies in species such as Xenopus, Drosophila, and Caenorhabditis have lent themselves quite well to further our understanding of the molecular basis of human diseases. A classical example is the identification and characterization of the Wnt/β-catenin pathway that is crucial in normal development including embryogenesis, organogenesis, and epithelial-mesenchymal transition and at the same time its deregulation is implicated in disorders such as cancers (reviewed in [1–3]). This pathway has remained conserved through the evolutionary process. In Drosophila, the role of Wnt or Wingless (Wg) was initially identified in normal wing development, however, it was later recognized for multiple functions such as inducing segment polarity and anterior–posterior patterning that were imperative for a viable embryo [4–6]. As the importance of Wnt emerged, several key components of this pathway were identified. The discovery of armadillo (or β-catenin) added a significant player to this orchestra and although circumstantial evidence suggesting such a relationship existed earlier it was a few years later that β-catenin was positively identified as a central component of the canonical Wg pathway [5, 7–9]. These studies led to the emergence of a model system for cell adhesion and signal transduction [10]. This was also the beginning of the understanding of the Wnt/β-catenin pathway and its role in complex cellular processes such as cell–cell adhesion, mitogenesis, motogenesis, and morphogenesis in the vertebrates.

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  1. Division of Experimental Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15261, USA

    Satdarshan P. S. Monga

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  1. Inselspital, Universität Bern, Murtenstr. 35, Bern, 3010, Switzerland

    Jean-Francois Dufour

  2. Klinik für Viszeral- und, Universitätsspital Zürich, Rämistr. 100, Zürich, 8091, Switzerland

    Pierre-Alain Clavien

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Monga, S.P.S. (2010). The WNT/β-Catenin Pathway. In: Dufour, JF., Clavien, PA. (eds) Signaling Pathways in Liver Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_25

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