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Erythrozyten

  • Chapter
Hämostaseologie

Zusammenfassung

Erythrozyten stellen mit einer Anzahl von 4,3–5,7 Mio./μl beim Mann bzw. 3,9–5,3 Mio./μl bei der Frau die häufigsten Zellen des Blutsystems und damit den mit Abstand größten Teil des zellulären Bestandteils des Bluts dar. Erythrozyten sind die einzigen kern- und organellenfreien Zellen des menschlichen Körpers und müssen daher aus kernhaltigen Progenitorzellen neu gebildet werden. Bei einer mittleren Lebensdauer von 120 Tagen bedeutet dies, dass jeden Tag ca. 200–300 Mrd. Erythrozyten gebildet und geordnet entsorgt werden müssen.

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Literatur

  • Akel A, Hermle T, Niemoeller OM et al. (2006) Stimulation of erythrocyte phosphatidylserine exposure by chlorpromazine. Eur J Pharmacol 532: 11–17

    Article  CAS  PubMed  Google Scholar 

  • Andrews DA, Yang L, Low PS (2002) Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells. Blood 100: 3392–3399

    Article  CAS  PubMed  Google Scholar 

  • Barvitenko NN, Adragna NC, Weber RE (2005) Erythrocyte signal transduction pathways, their oxygenation dependence and functional significance. Cell Physiol Biochem 15: 1–18

    Article  CAS  PubMed  Google Scholar 

  • Birka C, Lang PA, Kempe DS et al. (2004) Enhanced susceptibility to erythrocyte “apoptosis„ following phosphate depletion. Pflugers Arch 448: 471–477

    Article  CAS  PubMed  Google Scholar 

  • Brand VB, Sandu CD, Duranton C et al. (2003) Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. Cell Physiol Biochem 13: 347–356

    Article  CAS  PubMed  Google Scholar 

  • Bratosin D, Estaquier J, Petit F et al. (2001) Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ 8: 1143–1156

    Article  CAS  PubMed  Google Scholar 

  • Eisele K, Lang PA, Kempe DS et al. (2006) Stimulation of erythrocyte phosphatidylserine exposure by mercury ions. Toxicol Appl Pharmacol 210: 116–122

    Article  CAS  PubMed  Google Scholar 

  • Erslev A (1953) Humoral regulation of red cell production. Blood 8: 349–357

    CAS  PubMed  Google Scholar 

  • Fadok VA, Bratton DL, Rose DM et al. (2000) A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405: 85–90

    Article  CAS  PubMed  Google Scholar 

  • Kaestner L, Tabellion W, Lipp P et al. (2004) Prostaglandin E2 activates channel-mediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process. Thromb Haemost 92: 1269–1272

    CAS  PubMed  Google Scholar 

  • Kay MM (1975) Mechanism of removal of senescent cells by human macrophages in situ. Proc Natl Acad Sci USA. 72: 3521–3525

    Article  CAS  PubMed  Google Scholar 

  • Kempe DS, Lang PA, Eisele K et al. (2005) Stimulation of erythrocyte phosphatidylserine exposure by lead ions. Am J Physiol Cell Physiol 288: C396–C402

    Article  CAS  PubMed  Google Scholar 

  • Kempe DS, Lang PA, Duranton C et al. (2006) Enhanced programmed cell death of iron-deficient erythrocytes. FASEB J 20: 368–370

    CAS  PubMed  Google Scholar 

  • Kempe DS, Akel A, Lang PA et al. (2007) Suicidal erythrocyte death in sepsis. J Mol Med 85: 269–277

    Article  Google Scholar 

  • Lang KS, Roll B, Myssina S et al. (2002) Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem 12: 365–372

    Article  CAS  PubMed  Google Scholar 

  • Lang KS, Duranton C, Poehlmann H et al. (2003a) Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ 10: 249–256

    Article  CAS  PubMed  Google Scholar 

  • Lang KS, Myssina S, Tanneur V et al. (2003b) Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn Schmiedebergs Arch Pharmacol 367: 391–396

    Article  CAS  PubMed  Google Scholar 

  • Lang KS, Myssina S, Brand V et al. (2004a) Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ 11: 231–243

    Article  CAS  PubMed  Google Scholar 

  • Lang KS, Myssina S, Lang PA et al. (2004b) Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl. Am J Physiol Renal Physiol 286: F1046–F1053

    Article  CAS  PubMed  Google Scholar 

  • Lang PA, Kempe DS, Akel A et al. (2005) Inhibition of erythrocyte “apoptosis„ by catecholamines. Naunyn Schmiedebergs Arch Pharmacol 372: 228–235

    Article  CAS  PubMed  Google Scholar 

  • Lang F, Lang KS, Lang PA et al. (2006a) Mechanisms and significance of eryptosis. Antioxid Redox Signal 8: 1183–1192

    Article  CAS  PubMed  Google Scholar 

  • Lang PA, Beringer O, Nicolay JP et al. (2006b) Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome. J Mol Med 84: 378–388

    Article  PubMed  Google Scholar 

  • Lang PA, Huober J, Bachmann C et al. (2006c) Stimulation of erythrocyte phosphatidylserine exposure by paclitaxel. Cell Physiol Biochem 18: 151–164

    Article  CAS  PubMed  Google Scholar 

  • Lang PA, Schenck M, Nicolay JP et al. (2007) Liver cell death and anemia in Wilson’s disease involve acid sphingomyelinase and ceramide. Nat Med 13: 164–170

    Article  CAS  PubMed  Google Scholar 

  • Lee-Huang S (1984) Cloning and expression of human erythropoietin cDNA in Escherichia coli. Proc Nat Acad Sci USA 81: 2708–2712

    Article  CAS  PubMed  Google Scholar 

  • Low PS, Waugh SM, Zinke K et al. (1985) The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science 227: 531–533

    Article  CAS  PubMed  Google Scholar 

  • Lutz HU, Fasler S, Stammler P et al. (1988) Naturally occurring anti-band 3 antibodies and complement in phagocytosis of oxidativelystressed and in clearance of senescent red cells. Blood Cells 14: 175–203

    CAS  PubMed  Google Scholar 

  • Myssina S, Huber SM, Birka C et al. (2003) Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol 14: 2750–2757

    Article  CAS  PubMed  Google Scholar 

  • Myssina S, Lang PA, Kempe DS et al. (2004) Cl channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte ‘apoptosis’. Cell Physiol Biochem 14: 241–248

    Article  CAS  PubMed  Google Scholar 

  • Nicolay JP, Schneider J, Niemoeller OM et al. (2006) Stimulation of suicidal erythrocyte death by methylglyoxal. Cell Physiol Biochem 18: 223–232

    Article  CAS  PubMed  Google Scholar 

  • Nicolay JP, Gatz S, Liebig G et al. (2007) Amyloid induced suicidal erythrocyte death. Cell Physiol Biochem 19: 175–184

    Article  CAS  PubMed  Google Scholar 

  • Niemoeller OM, Akel A, Lang PA et al. (2006) Induction of eryptosis by cyclosporine. Naunyn Schmiedebergs Arch Pharmacol 374: 41–49

    Article  CAS  PubMed  Google Scholar 

  • Nunomura W, Takakuwa Y (2006) Regulation of protein 4.1R interactions with membrane proteins by Ca2+ and calmodulin. Front Biosci 11: 1522–1539

    Article  CAS  PubMed  Google Scholar 

  • Rivera A, Jarolim P, Brugnara C (2002) Modulation of Gardos channel activity by cytokines in sickle erythrocytes. Blood 99: 357–363

    Article  CAS  PubMed  Google Scholar 

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Wieder, T., Lang, F. (2010). Erythrozyten. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-01544-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01543-4

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