Abstract
Implantation is a complex process involving an intricate cascade of molecular interactions between the implanting blastocyst and the receptive endometrium. The molecular basis of endometrial receptivity and the mechanisms by which the blastocyst first adheres to the luminal epithelium and then penetrates into the stroma are only just beginning to be resolved. Advances in “omics” technologies, particularly proteomics and metabolomics, are set to have a major impact on the development of this field. In the wake of this information, novel targets for contraceptive intervention may become apparent.
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References
Baranao RI, Piazza A, Rumi LS, Polak de Fried E (1997) Determination of IL-1 and IL-6 levels in human embryo culture-conditioned media. Am J Reprod Immunol 37:191–194
Beier HM (1974) Oviducal and uterine fluids. J Reprod Fertil 37:221–237
Beier HM, Beier-Hellwig K (1998) Molecular and cellular aspects of endometrial receptivity. Hum Reprod Update 4:448–458
Beier-Hellwig K, Sterzik K, Bonn B, Beier HM (1989) Contribution to the physiology and pathology of endometrial receptivity: the determination of proteins patterns in human uterine secretions. Hum Reprod 4:115–120
Bermúdez MG, Wells D, Malter H, Munné S, Cohen J, Steuerwald NM (2004) Expression profiles of individual human oocytes using microarray technology. Reprod Biomed Online 8:325–337
Classen-Linke I, Alfer J, Krusche CA et al (2000) Progestins, progesterone receptor modulators, and progesterone antagonist change VEGF release of endometrial cells in culture. Steroids 65:763–771
Desai N, Filipovits J, Goldfarb J (2006) Secretion of soluble HLA-G by day 3 human embryos associated with higher pregnancy and implantation rates: assay of culture media using a new ELISA kit. Reprod Biomed Online 13:272–277
DeSouza L, Diehl G, Yang E, Guo J, Rodrigues MJ, Romaschin AD, Colgan TJ, Siu M (2005) Proteomic analysis of the proliferative and secretory phases of the human endometrium: Protein identification and differential protein expression. Proteomics 5:270–281
Dimitriadis E, White CA, Jones R, Salamonsen LA (2005) Cytokines, chemokines and growth factors in endometrium related to implantation. Hum Reprod Update 11:613–630
Dominguez F, Pellicer A, Simon C (2002) Paracrine dialogue in implantation. Mol Cell Endocrinol 186:175–181
Dominguez F, Gadea B, Mercader A, Esteban F, Pellicer A, Simon C (2008) Embryological outcome and secretome profile of implanted blastocyst obtained. Fertil Steril. doi:10.1016/j.fertnstert.2008.10.019. PMID 19062008
Dominguez F, Garrido-Gomez T, Lopez JA, Camafeita E, Quiñonero A, Pellicer A, Simon C (2009) Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin I and annexin A2 as diffrentially regulated. Hum Reprod 24:2607–2617
Domínguez F, Gadea B, Esteban FJ, Horcajadas JA, Pellicer A, Simón C (2008) Comparative protein-profile analysis of implanted versus non-implanted human blastocyst. Hum Reprod 23:1993–2000
Donnez J, Van Langendonckt A, Casanas-Roux F, Van Gossum JP et al (2002) Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 54:52–58
Finn CL, Martin L (1974) The control of implantation. J Reprod Fertil 39:195–206
Fowler PA, Tattum J, Bhattacharya S, Klonisch T, Hombach-Klonish S, Gazvani R, Lea RG, Miller I, Simpson WG, Cash P (2007) An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease. Proteomics 7:130–142
Fuzzi B, Rizzo R, Criscuoli L, Noci I, Melchiorri L, Scarselli B et al (2002) HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy. Eur J Immunol 32:311–315
Giudice LC (1999) Implantation and endometrial function. In: BCJM Fauser (ed) Molecular biology in reproductive medicine. Parthenon Publishing Group, New York, NY, USA, London, UK
Giudice LC (1999b) Potencial biochemical markers of uterine receptivity. Hum Reprod 14:3–16
Guerif F, Le Gouge A, Giraudeau B, Poindron J, Bidault R, Gasnier O, Royere D (2007) Limited value of morphological assessment at days 1 and 2 to predict blastocyst development potential: a prospective study based on 4042 embryos. Hum Reprod 22:1973–1981
Herrler A, von Rango U, Bier HM (2003) Embryo-maternal signalling: how the embryo starts talking to its mother to accomplish implantation. Reprod Biomed Online 6:244–256
Horcajadas JA, Pellicer A, Simón C (2007) Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update 13:77–86
Kämmerer U, von Wolff M, Markert UR (2004) Inmunology of human endometrium. Inmunobiology 209:569–574
Katz-Jaffe MG, Gardner DK, Schoolcraft WB (2006a) Proteomic analysis of individual human embryos to identify novel biomarkers of development and viability. Fertil Steril 85:101–107
Katz-Jaffe MG, Schoolcraft WB, Gardner DK (2006b) Analysis of protein expression (secretome) by human and mouse preimplantation embryos. Fertil Steril 86:678–685
Kitawaki J, Kado N, Ishihara H, Koshiba H et al (2002) Endometriosis: the pathophysiology as an estrogen-dependent disease. Steroid Biochem Mol Biol 83:149–155
Laird SM, Tuckerman EM, Dalton CF (1997) The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture. Hum Reprod 12:569–574
Li TC, Dalton C, Hunjan KS et al (1993a) The correlation of placental protein 14 concentrations in uterine flushings and endometrial morphology in the peri-implantation period. Hum Reprod 8:1923–1927
Li TC, MacKenna A, Roberts R (1993b) The techniques and complications of out-patient uterine washing in the assessment of endometrial function. Hum Reprod 8:343–346
Licht P, Losch A, Dittrich R et al (1998) Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis. Hum Reprod Update 4:532–538
Lindhard A, Bentin-Ley U, Ravn V (2002) Biochemical evaluation of endometrial function at the time of implantation. Fertil Steril 78:221–233
Maathuis JB, Aitken RJ (1978) Protein patterns of human uterine flushings collected at various stages of the menstrual cycle. J Reprod Fertil 53:343–348
Makkar G, Ng EH, Yeung WS, Ho PC (2006) Reduced expression of interleukin-11 and interleukin-6 in the peri-implantation endometrium of excessive ovarian responders during in-vitro fertilization treatment. J clin Endocrin Metab 91:3181–3188
Martín J, Dominguez F, Avila S, Castrillo JL, Remohí J, Pellicer A, Simón C (2002) Human endometrial receptivity: gene regulation. J Reprod Immunol 55:131–139
Olivennes F, Ledee-Bataille N, Samama M, Kadoch J, Taupin JL, Dubanchet S et al (2003) Assessment of leukemia inhibitary factor levels by uterine flushing at the time of egg retrieval does not adversely affect pregnancy rates with in vitro fertilization. Fertil Steril 79:900–904
Sheth KV, Roca GL, al-Sedairy ST, Parhar RS, Hamilton CJ, al-Abdul Jabbar F (1991) Prediction of successful embryo implantation by measuring interleukin-1-alpha and immunosuppressive factor(s) in preimplantation embryo culture fluid. Fertil Steril 55:952–957
Simon C, Mercader A, Frances A et al (1996) Hormonal regulation of serum and endometrial IL-1α, IL-1β and IL-1ra: IL-1 endometrial microenvironment of the human embryo at the apposition phase under physiological and supraphysiological steroid level conditions. J Reprod Inmunol 31:165–184
Stone BA, Petrucco OM, Seamark RF, Godfrey BM (1986) Concentrations of steroid hormones, and of prolactin, in washings of the human uterus during the menstrual cycle. J Reprod Fertil 78:21–25
Tabibzadeh S, Becker JL, Parsons AK (2003) Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid. Front Biosci 8:70–78
Van der Gaast MH, Beier-Hellwig K, Fauser BC, Beier HM, Macklon NS (2003) Endometrial secretion aspiration prior to embryo transfer does not reduce implantation rates. Reprod Biomed Online 7:105–109
Van der Gaast MH, Classen-Linke I, Krusche CA, Beier-Hellwig K, Fauser BCJM, Beier HM, Macklon NS (2008) Impact of ovarian stimulation on mid-luteal endometrial tissue and secretion markers of receptivity. RBM Online 4:553–563
Zhang H, Niu Y, Fend J, Guo H, Ye X, Cui H (2006) Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls. Fertil Steril 86:274–282
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Garrido-Gómez, T., Dominguez, F., Simón, C. (2010). Proteomics of Embryonic Implantation. In: Habenicht, UF., Aitken, R. (eds) Fertility Control. Handbook of Experimental Pharmacology, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02062-9_5
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DOI: https://doi.org/10.1007/978-3-642-02062-9_5
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