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Normal Bone Marrow: In Utero Through the Adult Years

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Pediatric and Adult MRI Atlas of Bone Marrow

Abstract

Hematopoiesis, the formation of blood cells, commences and is confined to the yolk sac of the fetus for the first 6 weeks. Between the sixth and twentieth weeks of age, the reticuloendothelial system, the liver and spleen, take over the process of blood cell formation [1]. From the sixteenth week, hematopoiesis commences in the bone marrow coinciding with the development of bone cavities [1, 2]. From then on, bone marrow remains the primary site for hematopoiesis. With advancing years, the number of sites and volume of hematopoietic bone marrow progressively decreases.

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References

  1. Steiner RM, Mitchell DG, Rao VM, Schweitzer ME. Magnetic resonance imaging of diffuse bone marrow disease. Radiol Clin North Am. 1993;31:383–409.

    CAS  PubMed  Google Scholar 

  2. Burdiles A, Babyn PS. Pediatric bone marrow MR imaging. Magn Reson Imaging Clin N Am. 2009;17(3):391–409, v.

    Google Scholar 

  3. Laor T, Jaramillo D. MR imaging insights into skeletal maturation: what is normal? Radiology. 2009;250(1):28–38.

    Article  PubMed  Google Scholar 

  4. Vogler 3rd JB, Murphy WA. Bone marrow imaging. Radiology. 1988;168(3):679–93.

    Article  PubMed  Google Scholar 

  5. Moore SG, Dawson KL. Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology. 1990;175:219–23.

    Article  CAS  PubMed  Google Scholar 

  6. Kuntz A, Richins CA. Innervation of the bone marrow. J Comp Neurol. 1945;83:213–22.

    Article  CAS  PubMed  Google Scholar 

  7. DePace DM, Webber RH. Electrostimulation and morphologic study of the nerves of the bone marrow of the albino rat. Acta Anat. 1975;93:1–18.

    Article  CAS  PubMed  Google Scholar 

  8. Trubowitz S, Davis S. The bone marrow matrix. In: The human bone marrow: anatomy, physiology and pathophysiology. Boca Raton: CRC; 1982. p. 43–75.

    Google Scholar 

  9. Siegel MJ. MRI of bone marrow. In: Ho VB, Kransdorf MJ, Reinhold C, editors. Body MRI. Reston: American Roentgen Ray Society; 2006. p. 169–78.

    Google Scholar 

  10. Darge K, Jaramillo D, Siegel MJ. Whole-body MRI in children: current status and future applications. Eur J Radiol. 2008;68(2):289–98.

    Article  PubMed  Google Scholar 

  11. Foster K, Chapman S, Johnson K. MRI of the marrow in the paediatric skeleton. Clin Radiol. 2004;59:651–73.

    Article  CAS  PubMed  Google Scholar 

  12. Jaramillo D, Laor T, Hoffer FA, et al. Epiphyseal marrow in infancy: MR imaging. Radiology. 1991;180:809–12. 2002;224:669–74.

    Google Scholar 

  13. Ricci C, Cova M, Kang YS, et al. Normal age-related patterns of cellular and fatty bone marrow distribution in the axial skeleton: MR imaging study. Radiology. 1990;177:83–8.

    Article  CAS  PubMed  Google Scholar 

  14. Zawin JK, Jaramillo D. Conversion of bone marrow in the humerus, sternum, and clavicle: changes with age on MR images. Radiology. 1993;188:159–64.

    Article  CAS  PubMed  Google Scholar 

  15. Taccone A, Oddone M, Dell’Acqua A, Occhi M, Ciccone MA. MRI “road-map” of normal age-related bone marrow. Pediatr Radiol. 1995;25:596–606.

    Article  CAS  PubMed  Google Scholar 

  16. Emery JL, Follett GF. Regression of bone marrow haemopoiesis from the terminal digits in the foetus and infant. Br J Haematol. 1964;10:485–9.

    Article  CAS  PubMed  Google Scholar 

  17. Haines RW. The histology of epiphyseal union in mammals. J Anat. 1975;120:1–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Ogden J. Anatomy and physiology of skeletal development: skeletal injury in the child. New York: Springer; 2000. p. 17–8.

    Google Scholar 

  19. Harcke HT, Snyder M, Caro PA, Bowen JR. Growth plate of the normal knee: evaluation with MR imaging. Radiology. 1992;183:119–23.

    Article  CAS  PubMed  Google Scholar 

  20. Sasaki T, Ishibashi I, Okamura Y, Toh S, Sasaki K. MRI evaluation of growth plate closure rate and pattern in the normal knee joint. J Knee Surg. 2002;15:72–6.

    PubMed  Google Scholar 

  21. Zbojniewicz AM, Laor T. Focal Periphyseal Edema (FOPE) zone on MRI of the adolescent knee: a potentially painful manifestation of physiologic physeal fusion? AJR Am J Roentgenol. 2011;197(4):998–1004.

    Article  PubMed  Google Scholar 

  22. Shabshin N, Schweitzer ME, Morrison WB, Carrino JA, Keller MS, Grissom LE. High-signal T2 changes of the bone marrow of the foot and ankle in children: red marrow or traumatic changes? Pediatr Radiol. 2006;36:670–6.

    Article  PubMed  Google Scholar 

  23. Scott JE, Bosworth TR, Cribb AM, Taylor JR. The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus. J Anat. 1994;184(Pt 1):73–82.

    PubMed  PubMed Central  Google Scholar 

  24. Mirowitz SA. Hematopoietic bone marrow within the proximal humeral epiphysis in normal adults: investigation with MR imaging. Radiology. 1993;188(3):689–93.

    Article  CAS  PubMed  Google Scholar 

  25. Vande Berg BC, Lecouvet FE, Galant C, Maldague BE, Malghem J. Normal variants and frequent marrow alterations that simulate bone marrow lesions at MR imaging. Radiol Clin North Am. 2005;43(4):761–70, ix.

    Google Scholar 

  26. Okada Y, Aoki S, Barkovich AJ, Nishimura K, Norman D, Kjos BO, Brasch RC. Cranial bone marrow in children: assessment of normal development with MR imaging. Radiology. 1989;171(1):161–4.

    Article  CAS  PubMed  Google Scholar 

  27. Yamada M, Matsuzaka T, Uetani M, Hayashi K, Tsuji Y, Nakamura T. Normal age-related conversion of bone marrow in the mandible: MR imaging findings. AJR Am J Roentgenol. 1995;165(5):1223–8.

    Article  CAS  PubMed  Google Scholar 

  28. Dolan KD. Paranasal sinus radiology, part IA: introduction and the frontal sinuses. Head Neck Surg. 1982;4(4):301–11.

    Article  CAS  PubMed  Google Scholar 

  29. Dolan KD. Paranasal sinus radiology, Part 3A: sphenoidal sinus. Head Neck Surg. 1982;5(2):164–76.

    Article  CAS  PubMed  Google Scholar 

  30. Simonson TM, Kao SC. Normal childhood developmental patterns in skull bone marrow by MR imaging. Pediatr Radiol. 1992;22(8):556–9.

    Article  CAS  PubMed  Google Scholar 

  31. Sebag GH, Dubois J, Tabet M, Bonato A, Lallemand D. Pediatric spinal bone marrow: assessment of normal age-related changes in the MRI appearance. Pediatr Radiol. 1993;23:515–8.

    Article  CAS  PubMed  Google Scholar 

  32. De Bruyn PPH, Breen PC, Thomas TB. The microcirculation of the bone marrow. Anat Rec. 1970;168:55–68.

    Article  PubMed  Google Scholar 

  33. Weiss L. The structure of bone marrow functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: an electron microscopic study. J Morphol. 1965;117:467–538.

    Article  CAS  PubMed  Google Scholar 

  34. Yao WJ, Hoh CK, Hawkins RA, et al. Quantitative PET imaging of bone marrow glucose metabolic response to hematopoietic cytokines. J Nucl Med. 1995;36:794–9.

    CAS  PubMed  Google Scholar 

  35. Hollinger EF, Alibazoglu H, Ali A, Green A, La-Monica G. Hematopoietic cytokine-mediated FDG uptake simulates the appearance of diffuse metastatic disease on whole-body PET imaging. Clin Nucl Med. 1998;23:93–8.

    Article  CAS  PubMed  Google Scholar 

  36. Bordalo-Rodrigues M, Galant C, Lonneux M, Clause D, Vande Berg BC. Focal nodular hyperplasia of the hematopoietic marrow simulating vertebral metastasis on FDG positron emission tomography. AJR Am J Roentgenol. 2003;180(3):669–71.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Imaging, University of California San Francisco Benioff Children’s Hospital at Oakland, Oakland, CA, USA

    S. Pinar Karakas-Rothey MD (Staff Radiologist)

  2. Cleveland Clinic Department of Radiology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Hakan Ilaslan MD (Associate Professor of Radiology)

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  1. S. Pinar Karakas-Rothey MD
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  2. Hakan Ilaslan MD
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Karakas-Rothey, S.P., Ilaslan, H. (2016). Normal Bone Marrow: In Utero Through the Adult Years. In: Pediatric and Adult MRI Atlas of Bone Marrow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02740-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-02740-6_1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02739-0

  • Online ISBN: 978-3-642-02740-6

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