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Signaling Pathways that Regulate C. elegans Life Span

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IGFs:Local Repair and Survival Factors Throughout Life Span

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Abstract

Insulin-like growth factor signaling and other endocrine axes contribute to stress and longevity regulation in C. elegans and other animals. By genetic and functional genomic analysis, we have identified players in this pathway. Many of these genes are conserved and likely to mediate endocrine regulation of longevity across the animal kingdom.

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Authors and Affiliations

  1. Department of Molecular Biology, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, CPZN-7250, MA, 02114, Boston, USA

    Gary Ruvkun

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  1. Gary Ruvkun
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  2. Andrew V. Samuelson
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  3. Christopher E. Carr
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  4. Sean P. Curran
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  5. David E. Shore
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Correspondence to Gary Ruvkun .

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Editors and Affiliations

  1. Chapel Hill, University of North Carolina, Burnett-Womack Hall 8024, Chapel Hill, 27599-7170, U.S.A.

    David Clemmons

  2. Lab. Endocrine Physiology, National Inst. Med. Research, The Ridgeway, London, NW7 1AA, United Kingdom

    Iain C.A.F. Robinson

  3. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Ruvkun, G., Samuelson, A.V., Carr, C.E., Curran, S.P., Shore, D.E. (2010). Signaling Pathways that Regulate C. elegans Life Span. In: Clemmons, D., Robinson, I., Christen, Y. (eds) IGFs:Local Repair and Survival Factors Throughout Life Span. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04302-4_6

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