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Supportivtherapie von Knochenmetastasen

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Medikamentöse Tumortherapie in der Uroonkologie

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Zusammenfassung

Bisphosphonate sind Analoga des anorganischen Pyrophosphats. Sie weisen eine hohe Affinität zur Mineralsubstanz des Knochens auf. Bisphosphonate können Komplexe mit zweiwertigen Kationen wie Ca2+ eingehen und zeigen daher eine hohe Bindungsfähigkeit zum Knochengewebe. Das Grundgerüst der Bisphosphonate sind zwei Phosphatgruppen, die an ein zentrales Kohlenstoffatom gebunden sind.

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Literatur

  • Berenson JR, Rosen LS, Howell A. Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases. Cancer 2001;91:1191–1200

    Article  CAS  PubMed  Google Scholar 

  • Fizazi, M.A. Carducci, M.R. Smith et al. (2010) A randomized phase III trial of denosumab versus zoledronic acid in patients with bone metastases from castration-resistant prostate cancer. J Clin Oncol (Suppl LBA 4507) 28:7

    Google Scholar 

  • Hillner BE, Ingle JN, Chlebowski RT, Gralow J, Yee C, Janjan NA, Cauley, Blumenstein BA, Albain KS, Lipton A, Brown S. American Society of Clinical Oncology 2003 Update on the role of bisphosphonates and bone health issues in women with breast cancer. J Clin Oncol 2003;21:4042–4057

    Article  CAS  PubMed  Google Scholar 

  • Saad F, Gleason DM, Murray R. A randomized, placebo-controlled trial of zoledronic acid in patients with hormonerefractory metastatic prostate carcinoma. J Natl Cancer Inst 2002;94:1458–1468

    CAS  PubMed  Google Scholar 

  • Smith MR, Egerdie B, Toriz NH, et al. N Engl J Med. 2009;361:745–755

    Google Scholar 

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Author information

Authors and Affiliations

  1. Urologische Klinik und Poliklinik, Technischen Universität München, Ismaninger Str. 22, 81675, München, Deutschland

    Prof. Dr. M. Retz

  2. Urologische Klinik und Poliklinik, Technischen Universität München, Ismaninger Str. 22, 81675, München, Deutschland

    Prof. Dr. J. Gschwend

Authors
  1. Prof. Dr. M. Retz
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  2. Prof. Dr. J. Gschwend
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© 2010 Springer-Verlag Berlin Heidelberg

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Retz, M., Gschwend, J. (2010). Supportivtherapie von Knochenmetastasen. In: Medikamentöse Tumortherapie in der Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10381-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-10381-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-10380-3

  • Online ISBN: 978-3-642-10381-0

  • eBook Packages: Medicine (German Language)

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