Summary
In this paper we propose a new procedure for peak detection in mass-spectrometry data using sparse deconvolution. We apply the procedure for estimation of the ion charges for isotopic patterns of overlapping peaks. The evaluation is performed on the thymosin β4 16-38 fragment measurements. Moreover, a comparison with the Mexican hat based algorithm of peak picking is provided.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andreev, V., Rejtar, T., et al.: Anal. Chem. 75, 6314–6326 (2003)
Bredies, K., Lorenz, D.: SIAM J. Sci. Comput. 30, 657–683 (2008)
Dahlke, S., Maass, P., et al.: Mathematical Methods in Time Series Analysis and Digital Image Processing, 75–109 (2007)
Klann, E., Kuhn, M. et al.: Inverse Probl. 23, 2231–2248 (2007)
Lange, E., Gröpl, C., et al.: Proc. Pacific Symp. on Biocomp. 243–245 (2006)
Lorenz, D.: J. Inverse Ill-Posed Probl. 16, 463–478 (2008)
Sturm, M., Bertsch, A., et al.: BMC Bioinformatics 9, 163 (2008)
Vivó-Truyols, G., Torres-Lapasió, J., et al.: J. Chromatrogr. A 1096, 146–155 (2005)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bredies, K., Alexandrov, T., Decker, J., Lorenz, D.A., Thiele, H. (2010). Sparse Deconvolution for Peak Picking and Ion Charge Estimation in Mass Spectrometry. In: Fitt, A., Norbury, J., Ockendon, H., Wilson, E. (eds) Progress in Industrial Mathematics at ECMI 2008. Mathematics in Industry(), vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12110-4_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-12110-4_43
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-12109-8
Online ISBN: 978-3-642-12110-4
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)