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Dünndarmtransplantation

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Praxis der Viszeralchirurgie. Gastroenterologische Chirurgie

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Zusammenfassung

Die Dünndarmtransplantation (DTx) ist eine noch junge Technik, die bei Patienten mit Kurzdarmsyndrom und Komplikationen der totalen parenteralen Ernährung (TPN) indiziert ist. Das International Intestinal Transplant Registry (IITR) erfasste bis 2005 weltweit bislang 989 DTx bei 923 Patienten in 61 registrierten Transplantationszentren. Ein Meilenstein in der Dünndarmtransplantation war die Einführung des Immunsuppressivums Tacrolimus, das gegenüber dem Ciclosporin eine effektivere Kontrolle von Transplantatabstoßungen ermöglichte. Mit der Etablierung von Tacrolimus als Basisimmunsuppressivum stieg die Anzahl der Dünndarmtransplantationen stetig an und erreichte 2001 erstmals 100 DTx pro Jahr. Von den bislang 989 Transplantationen erfolgten 43,8% als isolierte DTx, 39,0% als kombinierte Leber- und DTx (LDTx) und 17,2% als multiviszerale Transplantation (MTx).

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  1. Campus Kiel, Klinik für Allgemeinund Thoraxchirurgie, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Straße 7, 24105, Kiel

    Dr. med. F. Braun

  2. Campus Kiel Klinik für Angewandte Zelltherapie, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Straße 7, 24105, Kiel

    Prof. Dr. med. F. Fändrich

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  1. Dr. med. F. Braun
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  2. Prof. Dr. med. F. Fändrich
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  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    Jörg Rüdiger Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg

    Matthias Rothmund (Dekan) (Dekan)

  3. Universitätsklinik Aachen, Pauwelsstraße 30, 52074, Aachen

    Volker Schumpelick (Direktor der Chirurgischen) (Direktor der Chirurgischen)

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Braun, F., Fändrich, F., Müller, A., Platz, KP., Broering, D., Becker, T. (2011). Dünndarmtransplantation. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie. Gastroenterologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-14223-9_31

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