Skip to main content
SpringerLink
Log in

Pitfalls

  • Chapter
PET/CT-Atlas

  • 3145 Accesses

Zusammenfassung

Einleitung Wie in den vorangegangenen Kapiteln gezeigt werden konnte, ergibt sich durch die funktionale bzw. molekulare Bildgebung der PET/CT ein großes Potenzial zur Gewinnung zusätzlicher oder früherer Informationen über Entwicklung, Ausbreitung und ggf. Rezidiv einer bösartigen Erkrankung. Zugleich beinhaltet dieser Vorzug jedoch auch das Problem der Artefaktanfälligkeit bzw. die Möglichkeit der sog. falsch-positiven und falsch-negativen Befunde. Gute pathophysiologische Grundkenntnisse sowie ein gewisses Verständnis für die ablaufenden technisch- apparativen Prozesse helfen, derartige Pitfalls zumindest zu minimieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Andre M, Mounier N, Leleu X et al. (2003) Second cancers and late toxicities after treatment of aggressive non-Hodgkin’s lymphoma with the ACVBP regimen: a Gela-cohort study on 2837 patients. Blood 103: 1222–1228

    Article  PubMed  Google Scholar 

  2. Aziz TM, Saad RA, Glasser J et al. (2002) The management of second primary lung cancers. A single center experience in 15 years. Eur J Cardiothorac Surg 21: 527–533

    Article  PubMed  Google Scholar 

  3. Bairati I, Meyer F, Gekinas M et al. (2005) A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer. J Natl Cancer Inst 97: 481–488

    Article  PubMed  CAS  Google Scholar 

  4. Baxter NN, Tepper JE, Durham SB et al. (2005) Increased risk of rectal cancer after prostate radiation: a population-based study. Gastroenterology 128: 819–824

    Article  PubMed  Google Scholar 

  5. Bhatia S, Sklar C (2002) Second cancers in survivors of childhood cancer. Nat Rev Cancer 2: 124–132

    Article  PubMed  Google Scholar 

  6. Birgisson H, Pahlman L, Gunnarsson U, Glimelius B (2005) Occurence of second cancers in patients treated with radiotherapy for rectal cancer. J Clin Oncol 97: 6126–6131

    Article  Google Scholar 

  7. Brennan P, Scelo G, Hemminki K et al. (2005) Second primary cancers among 109 000 cases of non-Hodgkin’s lymphoma. Br J Cancer 93: 159–166

    Article  PubMed  CAS  Google Scholar 

  8. Brenner DJ, Hall EJ, Curtis RE, Ron E (2005) Prostate radiotherapy is associated with second cancers in many organs, not just the colorectum. Gastroenterology 129: 773–774

    PubMed  Google Scholar 

  9. Broniscer A, Ke W, Fuller CE et al. (2004) Second neoplasmas in pediatric patients with primary nervous system tumors: The St. Jude Children’s Research Hospital experience. Cancer 100: 2246–2252

    Article  PubMed  Google Scholar 

  10. Cannell E (2002) Second cancers among childhood survivors. Eur J Cancer 38: 2

    Google Scholar 

  11. Chiang JM, Yeh CY, Changehien CR et al. (2004) Clinical features of second other-side primary cancers among sporadic colorectal cancer patients – a hospital-based study of 3 722 cases. Hepatogastroenterology 51: 1341–1344

    PubMed  Google Scholar 

  12. Chuang SC, Hashibe M, Yu GP et al. (2006) Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers. Cancer Lett 238: 42–52

    Article  PubMed  CAS  Google Scholar 

  13. Cohade C, Osman M, Pannu HK, Wahl RL (2003) Uptake in supraclavicular area fat (“USA-FAT”): Description on 18F-FDG PET/CT. J Nucl Med 44: 170–176

    PubMed  CAS  Google Scholar 

  14. Cohen RJ, Curtis RE, Inskip PD, Fraumeni JF Jr. (2005) The risk of developing second cancers among survivors of childhood soft tissue sarcoma. Cancer 103: 2391–2396

    Article  PubMed  Google Scholar 

  15. Crocetti E, Carli P (2004) Risk of second primary cancers, other than melanoma, in Italian population-based cohort of cutaneous malignant melanoma patients. Eur J Cancer Prev 13: 33–37

    Article  PubMed  CAS  Google Scholar 

  16. Crocetti E, Miccinesi G, Paci E, Zapa M (2001) Incidence of second cancers among women with in-situ carcinoma of the breast. Breast 10: 438–441

    Article  PubMed  CAS  Google Scholar 

  17. Dieckmann KP, Claßen J, Loy V (2005) Präkanzerose der Hodentumoren: Testikuläre intraepitheliale Neoplasie. Dtsch Ärztebl 102: A3021–A3025

    Google Scholar 

  18. Diener-West M, Reynolds SM, Agugliaro DJ et al. (2005) Second primary cancers after enrollment in the COMS trials for treatment of choroidal melanoma: COMS Report No 25. Arch Ophthalmol. 123: 601–604

    Article  PubMed  Google Scholar 

  19. Dizendorf EV, Treyer V, von Schulthess GK, Hany TF (2002) Application of oral contrast media in co-registered positron emission tomography-CT. Am J Roentgenol 179: 477–481

    Google Scholar 

  20. Do KA, Johnson MM, Doherty DA et al. (2003) Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States). Cancer Causes Control 14: 131–138

    Article  PubMed  Google Scholar 

  21. Dong C, Lonnstedt I, Kemminki K (2001) Familiar testicular cancer and second primary cancer patients by histological type. Eur J Cancer 37(15): 1878–1885

    Article  PubMed  CAS  Google Scholar 

  22. Epstein JP, Feldman R, Dolor RJ, Porter SR (2003) The utility of tolonium chloride linse in the diagnosis of recurrent or second primary cancers in patients with prior upper aerodigestive tract cancer. Head and Neck 25: 911–921

    Article  PubMed  Google Scholar 

  23. Evans HS, Newnham A, Hodgson SV, Moller H (2003) Second primary cancers after cervical intraepithelial neoplasia III and invasive cervical cancer in Southeats England. Gynecol Oncol 90: 131–136

    Article  PubMed  CAS  Google Scholar 

  24. Feig SA (2001) Second malignant neoplasms after successful treatment of childhood cancers. Blood Cells Mol Dis 27: 662–666

    Article  PubMed  CAS  Google Scholar 

  25. Fowble B, Hanlon A, Freeman G et al. (2001) Second cancers after conservative surgery and radiation for stages I-II breast cancer: identifying a subset of women of increased risk. Int J Radiat Oncol Biol Phys 51: 679–690

    Article  PubMed  CAS  Google Scholar 

  26. Gao X, Fisher SG, Mohideen N, Emami B (2003) Second primary cancers in patients with laryngeal cancers: a population-based study. Int J Rad Oncol Biol Phys 56: 427–435

    Article  Google Scholar 

  27. Hall EH, Wuu CS (2003) Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Rad Oncol Biol Phys 56: 83–88

    Article  Google Scholar 

  28. Hanif MZ, Ghesani M, Shah AA, Kasai T (2004) F-18 fluorodeoxyglucose uptake in atherosclerotic plaque in the mediastinum mimicking malignancy: another potential for error. Clin Nucl Med 29: 93–95

    Article  PubMed  Google Scholar 

  29. Hany TF, Heuberger J, von Schulthess GK (2003) Iatrogenic FDG foci in the lungs: a pitfall of PET image interpretation. Eur Radiol 13: 2122–2127

    Article  PubMed  Google Scholar 

  30. Harrison RM (2004) Second cancers following radiotherapy: a suggested common dosimetry framework for the therapeutic and concomitant exposures. Br J Radiol 77: 986–990

    Article  PubMed  CAS  Google Scholar 

  31. Heller MT, Meltzer CC, Fukui MB et al. (2000) Superphysiological FDG uptake in the non-paralyzed vocal cord. Clin Positron Imaging 3: 207–211

    Article  PubMed  Google Scholar 

  32. Hemminki K, Li X (2003) Familial and second primary pancreatic cancers: a nation-wide epidemiologic study from Sweden. Int J Cancer 103: 525–530

    Article  PubMed  CAS  Google Scholar 

  33. Hemminki K, Yang Y (2002) Familial and second esophageal cancers: a nation-wide epidemiologic study from Sweden. Int J Cancer 98: 106–109

    Article  PubMed  CAS  Google Scholar 

  34. Hemminki K, Li X, Dong C (2001) Second primary cancers after sporadic and familiar colorectal cancer. Cancer Epidemiol Biomarkers Prev 10: 793–798

    PubMed  CAS  Google Scholar 

  35. Jacobsson H, Celsing F, Ingva M et al. (1998) Accumulation of FDG in axillary sweat glands in hyperhidrosis: a pitfall of wholebody PET examination. Eur Radiol 8: 482–483

    Article  PubMed  CAS  Google Scholar 

  36. Jeremic B (2002) Second primary cancers occuring in patients with early stage non-small-cell lung cancer treated with radiation therapy alone. Eur J Cardiothorac Surg 22: 1039–1040

    Article  PubMed  Google Scholar 

  37. Kerrou K, Montravers F, Grahek D et al. (2001) 18F-FDG uptake in soft tissue dermatome prior to herpes zoster eruption: an unusual pitfall. Ann Nucl Med 15: 455–458

    Article  PubMed  CAS  Google Scholar 

  38. Kim JS, Lee H, Kim H et al. (2004) Promoter methylation of retinoic acid receptor beta 2 and development of second primary lung cancers in non-small-cell lung cancer. J Clin Oncol 22: 3443–3450

    Article  PubMed  CAS  Google Scholar 

  39. Laccourreye O, Veivers FD, Hans S et al. (2002) Metachronous second primary cancers after successful partial laryngectomy for invasive squamous cell carcinoma of the true focal cord. Ann Otol Rhinol Laryngol 111: 204–209

    PubMed  Google Scholar 

  40. Ledermann RJ, Raylman RA, Fisher SJ et al (2001) Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglukose (FDG). Nucl Med Comm 22: 747–753

    Article  Google Scholar 

  41. Levi F, Randimbison L, Te VC, La Vecchia C (2003) Second primary cancers in laryngeal cancer patients. Eur J Cancer 39: 265–267

    Article  PubMed  Google Scholar 

  42. Li X, Hemminki K (2003) Familial and second lung cancers: a nation- wide epidemiologic study from Sweden. Lung Cancer 39: 255–263

    Article  PubMed  Google Scholar 

  43. Lippman SM, Lee JJ, Karp DD et al. (2001) Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. J Natl Cancer Inst 93: 605– 618

    Article  PubMed  CAS  Google Scholar 

  44. Maitra SK, Gallo H, Rowland-Payne C et al. (2005) Second primary cancers in patients with squamous cell carcinoma of the skin. Br J Cancer 92: 570–571

    PubMed  CAS  Google Scholar 

  45. Matesich SM, Shapiro CL (2003) Second cancer after breast cancer treatment. Semin Oncol 30: 740–748

    Article  PubMed  CAS  Google Scholar 

  46. Matsuyama Y, Tomonaga T, Nomura Y et al. (2000) Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan. Ann Oncol 30: 1537–1543

    Google Scholar 

  47. McClish D, Penberthy L, Pugh A (2003) Using Medicare claims to identify second primary cancers and recurrences in order to supplement a cancer registry. J Clin Epidemiol 56: 760–767

    Article  PubMed  Google Scholar 

  48. Miralbell R, Lomax A, Cella L, Schneider U (2002) Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys 54: 824–829

    Article  PubMed  Google Scholar 

  49. Moll AC, Imhof SM, Schouten-Van Meeteren AY et al. (2001) Second primary tumors in hereditary retinoblastoma: a registerbased study, 1945–1997. Ophthalmology 108: 1109–1114

    Article  PubMed  CAS  Google Scholar 

  50. Ortiz BH, Ailawadi M, Colitti C et al. (2001) Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors. Cancer Res 61: 7264– 7267

    PubMed  CAS  Google Scholar 

  51. Patel PM, Alibazoglu H, Ali A, Fordham E, LaMonica G (1996) Normal thymic uptake of FDG on PET imaging. Clin Nucl Med 21: 772–775

    Article  PubMed  CAS  Google Scholar 

  52. Pommegger R, Ensinger C, Steiner P et al. (2004) Neuroendocrine tumors and second primary malignancy – a relationship with clinical impact? Anticancer Res 24: 1049–1051

    Google Scholar 

  53. Sadetzki S, Calderon-Margalit R, Peretz C et al. (2003) Second primary breast and thyroid cancers (Israel). Cancer Causes Control 14: 367–375

    Article  PubMed  Google Scholar 

  54. Schlienger P, Campana F, Vilcoq JR et al. (2004) Nonocular second primary tumors after retinoblastoma: retrospective study of 111 patients treated by electron beam radiotherapy with or without TEM. Am J Clin Oncol 27: 411–419

    Article  PubMed  Google Scholar 

  55. Schulz CJ, Riddle MP, Valdimirsdottir HB et al. (2003) Impact on survivors of retinoblastoma when informed of study results on risk of second cancers. Med Pediatr Oncol 41: 36–43

    Article  PubMed  Google Scholar 

  56. Shreve PD, Anzai Y, Wahl RL (1999) Pitfalls in oncological diagnosis with FDG-PET imaging: physiologic and benign variants. Radiographics 19: 61–77

    PubMed  CAS  Google Scholar 

  57. Sigurdson AJ, Jones IM (2005) Second cancers after radiotherapy: any evidence for radiation-induced genomic instability? Radiat Res 163: 702–703

    PubMed  Google Scholar 

  58. Tateishi U, Hasegawa T, Miyakawa K et al. (2003) CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma. AJR Am J Roentgenol 181: 879–884

    PubMed  Google Scholar 

  59. Taussky D, Rubifach K, Huguenin P, Allal AS (2005) Risk factors for developing a second upper aerodigestive cancer after radiotherapy with or without chemotherapy in patients with head-andneck cancers: an exploratory outcomes analysis. Int J Rad Oncol Biol Phys 62: 684–689

    Article  Google Scholar 

  60. Tellenberg C, Malmer B, Tavelin B, Gronberg H (2003) Second primary cancers in men with prostate cancer: an increased risk of breast cancer. J Urol 169: 1345–1348

    Article  Google Scholar 

  61. Tichansky DS, Cagir B, Borrazzo E et al. (2002) Risk of second cancers in patients with colorectal carcinoids. Dis Colon Rectum 45: 91–97

    Article  PubMed  Google Scholar 

  62. Tomek MS, McGuirt WF (2003) Second head and neck cancers and tabacco usage. Am J Otolaryngol 24: 24–27

    Article  PubMed  Google Scholar 

  63. Toth-Molnar E, Hammer H (2005) Secondary malignant tumors in patients with ocular melanoma. Magy Onkol 49: 27–30

    PubMed  Google Scholar 

  64. Travis LB, Boice JD Jr, Travis WD (2003) Second primary cancer after thymoma. Int J Cancer 107: 868–870

    Article  PubMed  CAS  Google Scholar 

  65. Travis LB, Fossa SD, Schonfeld SJ et al. (2005) Second cancers among 40.576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 97: 1354–1365

    Article  PubMed  Google Scholar 

  66. Turkic M, Znaor A, Novosel I et al. (2005) Second primary malignant tumors in patients with primary renal cell carcinoma. Acta Med Croatica 59: 91–95

    PubMed  Google Scholar 

  67. Wu X, Zhao H, Do KA et al. (2004) Serum levels of insulin growth factor (IGF-1) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer. Clin Cancer Res 10: 3988–3995

    Article  PubMed  CAS  Google Scholar 

  68. Yasui Y, Liu Y, Neglia JP et al. (2003) A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancer. Am J Epidemiol 158: 1108–1113

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diagnostisch Therapeutisches Zentrum, Kadiner Straße 23, 10243, Berlin

    Prof. Dr. med. Wolfgang Mohnike

  2. Kuckucksweg 25, 61462, Königstein

    Prof. Dr. med. Gustav Hör

  3. UCLA Molecular & Medical Pharmacology, 956948, 90095-6948, B2-085J CHS, Los Angeles, USA

    Prof. Dr. med. Heinrich Schelbert

Authors
  1. Prof. Dr. med. Wolfgang Mohnike
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. med. Gustav Hör
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr. med. Heinrich Schelbert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mohnike, W., Hör, G., Schelbert, H. (2011). Pitfalls. In: PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17805-4_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-17805-4_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-17804-7

  • Online ISBN: 978-3-642-17805-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation