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Radioligand Studies in Depression

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Nuclear Medicine in Psychiatry

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Abstract

The availability of suitable radioligands is one of the important limiting factors in the further development of positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of human cerebral receptors and transporters. Currently, the available ligands allow the investigation of 5-HT2A, 5-HT1A and dopamine D2 receptors, and the serotonin and dopamine transporter. 5-HT2A receptors have been investigated most extensively. Overall findings are rather discordant. Among others, heterogeneity and size of clinical samples, previous treatments and, more particularly as far as 5-HT2A receptors are concerned, suicidality could be major confounding variables. Most, albeit not all, studies find an increased 5-HT2A ligand binding after SSRI treatment. Findings on the dopamine D2 receptors in depression are controversial, but successful SSRI treatment seems to be associated with increased D2 ligand binding. A few studies have looked at the 5-HT1A receptor and demonstrated decreases in binding. The one study which looked at the effect of an SSRI treatment found no effect. Serotonin transporter availability seems to be reduced in depression; its blockade was confirmed in those studies that investigated this transporter on SSRI treatment. Only one study has looked at the dopamine transporter and showed an increased ligand uptake.

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Authors and Affiliations

  1. Psychiatric Department, Academic Hospital, Free University of Brussels (V.U.B.), Laarbeeklaan 101, 1090, Brussels, Belgium

    Hugo D’haenen

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  1. Hugo D’haenen
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Editor information

Editors and Affiliations

  1. Division of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Andreas Otte  & Rudi A. Dierckx  & 

  2. University Department of Psychiatry, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Kurt Audenaert  & Kees van Heeringen  & 

  3. Department of Medical Imaging Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kathelijne Peremans

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© 2004 Springer-Verlag Berlin Heidelberg

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D’haenen, H. (2004). Radioligand Studies in Depression. In: Otte, A., Audenaert, K., Peremans, K., van Heeringen, K., Dierckx, R.A. (eds) Nuclear Medicine in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18773-5_21

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  • DOI: https://doi.org/10.1007/978-3-642-18773-5_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62287-8

  • Online ISBN: 978-3-642-18773-5

  • eBook Packages: Springer Book Archive

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