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Marine Organisms and Their Prospective Use in Therapy of Human Diseases

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Part of the book series: Parasitology Research Monographs ((Parasitology Res. Monogr.,volume 1))

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Abstract

Marine ecosystems show remarkable chemical, biological, and ecological diversities which have inspired marine natural product chemists for many years to identify novel chemical entities possessing potent pharmacological activities that could be eventually developed into therapeutics for human diseases such as cancer, analgesia, microbial infections, allergy, and immune diseases. By 1974, cytarabine (Ara-C, Cytosar-U®) and vidarabine (Ara-A, Vira-A®) were the first two marine-derived pharmaceuticals in the US pharmacopeia to treat human diseases. Since then, it took more than three further decades to introduce the next marine-derived drugs namely ω-conotoxin MVIIA (ziconotide, Prialt®), which was approved in December 2004 as an analgesic against severe chronic pain, and ecteinascidin (ET-743, Yondelis®) which was approved in October 2007 for the treatment of advanced soft tissue sarcomas, to the drug market. In addition many other marine-derived natural products are presently either in clinical or preclinical trial phases.

In this chapter, we survey the history of marine-derived therapeutics and the current status of the marine pharmaceutical pipeline with particular attention regarding the obstacles that may hinder transferring the marine-derived natural products into clinical trials and suggest possible solutions for introducing more drugs from the sea to the pharmaceutical market.

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Acknowledgement

Continuous support by BMBF to P.P. is gratefully acknowledged. A predoctoral fellowship granted and financed by the Egyptian government (Ministry of High Education) to S.S.E. is acknowledged.

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  1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, 40225, Duesseldorf, Germany

    Sherif S. Ebada & Peter Proksch

  2. Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Ain-Shams University, Organisation of African Unity 1, 11566, Cairo, Egypt

    Sherif S. Ebada

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    Heinz Mehlhorn

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Ebada, S.S., Proksch, P. (2011). Marine Organisms and Their Prospective Use in Therapy of Human Diseases. In: Mehlhorn, H. (eds) Nature Helps.... Parasitology Research Monographs, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19382-8_7

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