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Natural Antisense Transcripts Mediate Regulation of Gene Expression

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From Nucleic Acids Sequences to Molecular Medicine

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and posttranscriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Karolinska Institutet previously published part of this work as Mohammad Ali Faghihi’s thesis.

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Authors and Affiliations

  1. Department of Psychiatry & Behavioral Sciences, Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, Biomedical Research Building (BRB) Room#429, 1501 NW 10th Avenue, Miami, FL, 33136, USA

    Marco Magistri & Mohammad Ali Faghihi

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  1. Marco Magistri
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  2. Mohammad Ali Faghihi
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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Magistri, M., Faghihi, M.A. (2012). Natural Antisense Transcripts Mediate Regulation of Gene Expression. In: Erdmann, V., Barciszewski, J. (eds) From Nucleic Acids Sequences to Molecular Medicine. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27426-8_10

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