Abstract
This study’s objective is to compare image quality in 3-D molecular breast imaging tomosynthesis (MBIT) with that in planar molecular breast imaging (MBI) over a range of breast radioactivity concentrations. Using gelatin and point source phantoms lesion contrast, lesion signal-to-noise ratio (SNR) and spatial resolution were compared for a range of lesion sizes and depths. For both MBI and MBIT, lesion contrast is essentially constant with changing activity while SNR decreases by a factor of 1.5 – 2 between 100% and 25% activity levels. For nearly all lesion sizes and locations contrast and SNR are significantly higher for MBIT than MBI, potentially permitting greater reductions in injected dose. Spatial resolution in MBI is dependent on lesion depth but independent of lesion location with MBIT. Reconstructed MBIT spatial resolution is substantially better than that in the projection images, suggesting future use of higher sensitivity collimators for even further reductions in injected activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Breast Cancer Statistics (October 15, 2011), http://www.breastcancer.org/symptoms/understand_bc/statistics.jsp
Maublant, J., De Latour, M., Mestas, D., Clemenson, A., Charrier, S., Feillel, V., Le Bouedec, G., Kaufmann, P., Dauplat, J., Veyre, A.: Technetium-99m-sestamibi uptake in breast tumor and associated lymph nodes. J. Nucl. Med. 37, 922–925 (1996)
O’Connor, M., Rhodes, D., Hruska, C.: Molecular breast imaging. Expert Review of Anticancer Therapy 9, 1073–1080 (2009) [Review] [37 refs]
O’Connor, M.K., Li, H., Rhodes, D.J., Hruska, C.B., Clancy, C.B., Vetter, R.J.: Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast. Med. Phys. 37, 6187–6198 (2010)
Rhodes, D.J., Hruska, C.B., Phillips, S.W., Whaley, D.H., O’Connor, M.K.: Dedicated dual-head gamma imaging for breast cancer screening in women with mammographically dense breasts. Radiology 258, 106–118 (2011)
Wackers, F.J.T., Berman, D.S., Maddahi, J., Watson, D.D., Beller, G.A., Stauss, H.W.B.C.A., Picard, M., Holman, B.L., Fridrich, R., Inglese, E., Deslaloye, B., Bischof-Delaloye, A., Camin, L.M.K.: Technetium-99m hexakis 2-methoxyisobutyl isonitrile: Human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J. Nucl. Med. 30, 301–311 (1989)
Williams, M.B., Judy, P.G., Gunn, S., Majewski, S.: Dual modality breast tomosynthesis. Radiology 255, 191–198 (2010)
Williams, M.B., Narayanan, D., More, M.J., Goodale, P.J., Majewski, S., Kieper, D.A.: Analysis of position-dependent compton scatter in scintimammography with mild compression. IEEE Transactions on Nuclear Science 50, 1643–1649 (2003)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sullivan, O., Gong, Z., Klanian, K., Patel, T., Williams, M.B. (2012). The Impact of Reduced Injected Radioactivity on Image Quality of Molecular Breast Imaging Tomosynthesis. In: Maidment, A.D.A., Bakic, P.R., Gavenonis, S. (eds) Breast Imaging. IWDM 2012. Lecture Notes in Computer Science, vol 7361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31271-7_39
Download citation
DOI: https://doi.org/10.1007/978-3-642-31271-7_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31270-0
Online ISBN: 978-3-642-31271-7
eBook Packages: Computer ScienceComputer Science (R0)