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Cytology of Epithelial Proliferative Lesions and High-Grade Ductal Carcinoma In Situ

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Fine Needle Aspiration Cytology of the Breast

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Abstract

With the advent of mammographic screening, non-palpable lesions are increasingly detected. As the central dogma of triple assessment is frequently regarded as the gold standard in breast lesion assessment, some form of pathological evaluation is often performed. Both fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) are routinely used. CNB is generally considered superior to FNAC in dealing with these clinically elusive lesions that are only detected by either architectural distortion or more commonly by the presence of calcifications. CNB, compared to FNAC, has a higher sensitivity, specificity, and positive predictive value for malignancy and lower inadequacy rate. As a result, many centers preferentially perform CNB for such evaluation, and the pure cytologic experience in dealing with these lesions are limited. In the literature, there are sporadic reports confirming the usefulness of FNAC when the clinical and radiological findings are taken into consideration.

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Authors and Affiliations

  1. Prince of Wales Hospital Department of Anatomical And Cellular Pathology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR

    Dr. Gary Tse

  2. Department of Pathology, Singapore General Hospital, Singapore, Singapore

    Dr. Puay Hoon Tan

  3. Department of Pathology and Oncology, Medical Faculty of Porto University and IPATIMUP, Porto, Portugal

    Prof. Dr. Fernando Schmitt

Authors
  1. Nour Sneige
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  2. Dr. Gary Tse
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  3. Dr. Puay Hoon Tan
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  4. Prof. Dr. Fernando Schmitt
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Sneige, N., Tse, G., Tan, P.H., Schmitt, F. (2013). Cytology of Epithelial Proliferative Lesions and High-Grade Ductal Carcinoma In Situ. In: Fine Needle Aspiration Cytology of the Breast. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35000-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-35000-9_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-34999-7

  • Online ISBN: 978-3-642-35000-9

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