Skip to main content

Incidence and Prognostic Factors for Complications After Permanent Interstitial Brachytherapy

  • Chapter
  • First Online:
Interstitial Prostate Brachytherapy
  • 1198 Accesses

Abstract

Recent improvements in radioactive seed implantation techniques have established prostate brachytherapy as a highly effective treatment modality for localized prostate cancer, with long-term local and biochemical control similar to outcomes observed after radical prostatectomy and external beam radiation therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arterbery VE, Wallner K, Roy J, Fuks Z (1993) Short – term morbidity from CT-planned transperineal 125J prostate implants. Int J Radiat Oncol Biol Phys 25:661–667

    Article  PubMed  CAS  Google Scholar 

  • Benoit RM, Naslund M, Cohen JL (2000) Complications after prostate brachytherapy in the Medicare population. Urology 55:91–96

    Article  PubMed  CAS  Google Scholar 

  • Beyer DC, Priestly JB Jr (1997) Biochemical disease-free survival following I-125 prostate implantation. Int J Radiat Oncol Biol Phys 37:559–563

    Article  PubMed  CAS  Google Scholar 

  • Bottomley D, Ash D, Al-Quaisieh B et al (2007) Side effects of permanent I125 prostate seed implants in 667 patients treated in Leeds. Radiother Oncol 82:46–49

    Article  PubMed  Google Scholar 

  • Brown D, Colonias A, Miller R, Benoit R, Cohen J, Arshoun Y (2000) Urinary morbidity with a modified peripheral loading technique of transperineal 125J implantation. Int J Radiat Oncol Biol Phys 47:353–361

    Article  PubMed  CAS  Google Scholar 

  • Davis JD, Horwitz EM, Lee RW et al (2012) American Brachytherapy Society consensus guidelines for transrectal ultrasound-guided permanent prostate brachytherapy. Brachytherapy 11:6–19

    Article  PubMed  Google Scholar 

  • Gelblum DY, Potters L (2000) Rectal complications associated with transperineal interstitial brachytherapy for prostate cancer. Int J Radiat Oncol Biol Phys 48:119–124

    Article  PubMed  CAS  Google Scholar 

  • Gelblum DY, Potters L, Ashley R, Waldbaum R, Wang XH, Leibel S (1999) Urinary morbidity following ultrasound-guided transperineal prostate seed implantation. Int J Radiat Oncol Biol Phys 45:59–65

    Article  PubMed  CAS  Google Scholar 

  • Grimm P, Billiet I, Bostwick D, Dicker A, Frank S, Immerzeel J, Keyes M, Kupelian P, Lee WR, Machtens S et al (2012) Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group. BJU Int 109(Suppl 1):22–29

    Article  PubMed  Google Scholar 

  • Kao J, Stock RG, Stone NN (2000) Long-term erectile function following real-time ultrasound-guided brachytherapy for prostate cancer. J Urol 163:1276 (abstract)

    Article  Google Scholar 

  • Keyes M, Spadinger I, Liu M et al (2012) Rectal toxicity and rectal dosimetry in low-dose-rate iodine-125 permanent prostate implants: a long-term study in 1006 patients. Brachytherapy 11(3):199–208

    Article  PubMed  Google Scholar 

  • Kleinberg L, Wallner K, Roy J, Zelefsky M, Artebery VE (1994) Treatment-related symptoms during the first year following transperineal 125J prostate implantation. Int J Radiat Oncol Biol Phys 28:985–991

    Article  PubMed  CAS  Google Scholar 

  • Machtens S, Baumann R, Hagemann J et al (2006a) Long-term results of interstitial brachytherapy (LDR-brachytherapy) in the treatment of patients with prostate cancer. World J Urol 24(3):289–295

    Article  PubMed  Google Scholar 

  • Machtens S, Karstens JH, Baumann R, Jonas U (2006b) Interstitial brachytherapy (LDR-brachytherapy) in the treatment of patients with prostate cancer. Eur Urol Suppl 5:514–521

    Article  Google Scholar 

  • Merrick GS, Butler WM, Lief JH, Stipetich RL, Abel LJ, Dorsey AT (1999) Efficacy of sildenafil citrate in prostate brachytherapy patients with erectile dysfunction. Urology 53:1112–1116

    Article  PubMed  CAS  Google Scholar 

  • Merrick GS, Butler WM, Lief JH, Dorsey LT (2000) Temporal resolution of urinary morbidity following prostate brachytherapy. Int J Radiat Oncol Biol Phys 47:121–126

    Article  PubMed  CAS  Google Scholar 

  • Merrick GS, Butler WM, Galbreath RW, Stipetich RL, Abel LJ, Lief JH (2002a) Erectile function after permanent prostate brachytherapy. Int J Radiat Oncol Biol Phys 52:893–902

    Article  PubMed  Google Scholar 

  • Merrick GS, Butler WM, Wallner KE (2002b) The importance of radiation doses to the penile bulb vs. crura in the development of postbrachytherapy erectile dysfunction. Int J Radiat Oncol Biol Phys 54:1055–1062

    Article  PubMed  Google Scholar 

  • Nag S, Scaperoth DD, Badalament R, Hall SA, Burgers J (1995) Transperineal palladium-103 prostate brachytherapy: analysis of morbidity and seed migration. Urology 45:87–92

    Article  PubMed  CAS  Google Scholar 

  • Potters L, Torre T, Fearn PA, Leibel SA, Kattan MW (2001) Potency after permanent prostate brachytherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 50:1235–1242

    Article  PubMed  CAS  Google Scholar 

  • Ragde H, Blasko JC, Grimm PD, Kenny GM, Sylvester JE (1997) Interstitial iodine-125 radiation without adjuvant therapy in the treatment of clinically localized prostate carcinoma. Cancer 80:442–448

    Article  PubMed  CAS  Google Scholar 

  • Shah JN, Ennis RD (2006) Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors. Int J Radiat Oncol Biol Phys 64:817–824

    Article  PubMed  Google Scholar 

  • Stember DS, Mulhall JP (2012) The concept of erectile function preservation (penile rehabilitation) in the patient after brachytherapy for prostate cancer. Brachytherapy 11:87–96

    Article  PubMed  Google Scholar 

  • Stock RG, Kao J, Stone NN (2001) Penile erectile function after permanent radioactive seed implantation for treatment of prostate cancer. J Urol 165(2001):436–439

    Article  PubMed  CAS  Google Scholar 

  • Storey MR, Landgren RC, Cottone R (1999) Transperineal iodine-125 implantation for treatment of clinically localized prostate cancer: 5-year tumor control and morbidity. Int J Radiat Oncol Biol Phys 43:565–571

    Article  PubMed  CAS  Google Scholar 

  • Terk MD, Stock RG, Stone NN (1998) Identification of patients at increased risk for prolonged urinary retention following radioactive seed implantation of the prostate. J Urol 160:1379–1382

    Article  PubMed  CAS  Google Scholar 

  • Theodorescu D, Gillenwater JY, Schneider BF, Koutrouvelis PG (2000) Prostatourethral-rectal fistula following prostate brachytherapy: incidence and risk factors. J Urol 163:1294 (abstract)

    Google Scholar 

  • Wallner K, Roy J, Harrison L (1996) Tumor control and morbidity following transperineal iodine-125 implantation for stage T1/T2 prostatic carcinoma. J Clin Oncol 14:449–453

    PubMed  CAS  Google Scholar 

  • Wallner K, Lee H, Wassermann S, Dattoli M (1997) Low risk of urinary incontinence following prostate brachytherapy in patients with prior transurethral resection. Int J Radiat Oncol Biol Phys 37:565–569

    Article  PubMed  CAS  Google Scholar 

  • Waterman FM, Dicker AP (2003) Probability of late rectal morbidity in 125 I prostate ­brachytherapy. Int J Radiat Oncol Biol Phys 55:342–353

    Article  PubMed  Google Scholar 

  • Zeitlin SI, Sherman J, Raboy A, Lederman G, Albert P (1998) High dose combination radiotherapy for the treatment of localized prostate cancer. J Urol 160:91–95

    Article  PubMed  CAS  Google Scholar 

  • Zelefsky MJ, Wallner KE, Ling CC, Raben A, Hollister T, Wolfe T (1999) Comparison of 5-year outcome and morbidity of three-dimensional conformal radiotherapy versus transperineal ­permanent iodine-125 implantation for early-stage prostatic cancer. J Clin Oncol 17:517–523

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefan Machtens .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Machtens, S. (2013). Incidence and Prognostic Factors for Complications After Permanent Interstitial Brachytherapy. In: Kovács, G., Hoskin, P. (eds) Interstitial Prostate Brachytherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36499-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-36499-0_18

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-36498-3

  • Online ISBN: 978-3-642-36499-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics