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Cyclodextrin-Based Chiral Stationary Phases for Supercritical Fluid Chromatography

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Modified Cyclodextrins for Chiral Separation

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Abstract

In this chapter, a general introduction of supercritical fluid and supercritical fluid chromatography (SFC) is firstly provided. An overview of commercially available or newly developed packed columns for enantiomeric separation based on cyclodextrin chiral stationary phases (CSPs) in SFC is then presented. The correlations between cyclodextrin structures and their enantioselectivities are also discussed. Furthermore, the analytical conditions for optimization of enantiomeric separation with these cyclodextrin-based CSPs are discussed in detail.

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Authors and Affiliations

  1. Key Laboratory of Soft Chemistry and Functional Materials (Ministry of Education of China), Nanjing University of Science and Technology, Nanjing, 210094, People’s Republic of China

    Yun Dai & Weihua Tang

  2. Division of Chemical and Biomolecular Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore

    Siu-Choon Ng

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  1. Yun Dai
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  2. Weihua Tang
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  3. Siu-Choon Ng
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Correspondence to Weihua Tang .

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Editors and Affiliations

  1. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Weihua Tang

  2. , School of Chemical and Biomedical, Nanyang Technological University, Nanyang Drive 62, Singapore, 637459, Singapore

    Siu-Choon Ng

  3. Technology, Key Laboratory of Soft Chemistry and, Nanjing University of Science and, Xiaolingwei Street 200, Nanjing, 210094, China, People's Republic

    Dongping Sun

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Dai, Y., Tang, W., Ng, SC. (2013). Cyclodextrin-Based Chiral Stationary Phases for Supercritical Fluid Chromatography. In: Tang, W., Ng, SC., Sun, D. (eds) Modified Cyclodextrins for Chiral Separation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37648-1_4

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