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The Involvement of Calcium Channel α2δ Subunits in Diseases and as a Therapeutic Target

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Pathologies of Calcium Channels

Abstract

The α2δ subunits are auxiliary subunits of voltage-gated calcium channels that may also have roles independent of calcium channels. Four mammalian α2δ subunits have been identified, and all of them have been identified to play a role in a variety of pathologies. Furthermore, two α2δ subunits (α2δ-1 and α2δ-2) are pharmacological targets for the gabapentinoid drugs, which are used therapeutically in the treatment of epilepsies and neuropathic pain.

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Authors and Affiliations

  1. Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London, WC1E 6BT, UK

    Annette C. Dolphin

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  1. Annette C. Dolphin
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Correspondence to Annette C. Dolphin .

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  1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  2. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

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Dolphin, A.C. (2014). The Involvement of Calcium Channel α2δ Subunits in Diseases and as a Therapeutic Target. In: Weiss, N., Koschak, A. (eds) Pathologies of Calcium Channels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40282-1_5

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