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Autologous Matrix-Induced Chondrogenesis (AMIC)-Aided Repair of Osteochondral Lesions of the Talus

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Techniques in Cartilage Repair Surgery

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Abstract

The autologous matrix-induced chondrogenesis (AMIC) technique was first reported by Behrens in 2005 [1, 2] and has been initially described for treatment of full-thickness cartilage defects in the knee joint [3, 4]. This one-step procedure combines debridement of the cartilage lesion and microfracturing of the subchondral bone to release bone marrow, containing mesenchymal stem cells (MSCs). The defect is then covered by a commercially available collagen I/III matrix to cover and stabilise the resulting blood clot. The scaffold is fixed with autologous or partial autologous fibrin glue [5].

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Author information

Authors and Affiliations

  1. Orthopaedic Department, University Hospital of Basel, Spitalstrasse 21, Basel, 4031, Switzerland

    Martin Wiewiorski MD & Victor Valderrabano MD, PhD

Authors
  1. Martin Wiewiorski MD
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  2. Victor Valderrabano MD, PhD
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Corresponding author

Correspondence to Martin Wiewiorski MD .

Editor information

Editors and Affiliations

  1. Department of Minimally Invasive Surgery, Faculty of Health and Social Sciences, Canterbury Christ Church University, Chatham Maritime, Kent, UK

    Asode Ananthram Shetty MD, PhD, MCh, FRCS Ed., FRCS Eng., FRCS Orth

  2. Faculty of Stem Cell Research and Regenerative Medicine, NITTE University, Mangalore, India

    Asode Ananthram Shetty MD, PhD, MCh, FRCS Ed., FRCS Eng., FRCS Orth  & Seok-Jung Kim MD, PhD, FRCS  & 

  3. Department of Orthopaedic Surgery, Uijeongbu St. Mary’s Hospital College of Medicine The Catholic University of Korea, Gyeonggi-do, Korea, Republic of, South Korea

    Seok-Jung Kim MD, PhD, FRCS

  4. Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan

    Norimasa Nakamura MD, PhD

  5. Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan

    Norimasa Nakamura MD, PhD

  6. Cartilage Research Unit Department of Orthopaedic, University of Gothenburg, Kungsbacka, Sweden

    Mats Brittberg MD, PhD

  7. Region Halland Orthopaedics Kungsbacka Hospital, Kungsbacka, Sweden

    Mats Brittberg MD, PhD

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© 2014 ESSKA

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Wiewiorski, M., Valderrabano, V. (2014). Autologous Matrix-Induced Chondrogenesis (AMIC)-Aided Repair of Osteochondral Lesions of the Talus. In: Shetty, A.A., Kim, SJ., Nakamura, N., Brittberg, M. (eds) Techniques in Cartilage Repair Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41921-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-41921-8_22

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-41920-1

  • Online ISBN: 978-3-642-41921-8

  • eBook Packages: MedicineMedicine (R0)

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